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How will summer weather shape the spread of COVID-19?
June 10, 2020 -- New research shows that while higher temperatures and humidity can slow the spread of COVID-19, longer hours of sunlight are associated with a higher incidence of the disease. Human behavior may be at the root of this quandary, according to a June 8 Geographical Analysis publication.  Discuss
FDA researchers explore vaccine responses to SARS-CoV-2 antigens
June 9, 2020 -- Different proteins associated with SARS-CoV-2, the virus that causes COVID-19, generate unique immune responses when given to rabbits as immunizations, according to a June 8 Science Translational Medicine article.  Discuss
Transparency helps maintain scientific integrity of clinical trials
June 9, 2020 -- A new study offers reassuring evidence about the integrity of registered clinical trials, with researchers finding no signs of widespread manipulation of results regarding statistical significance thresholds. The study results were published in the Proceedings of the National Academy of Sciences on June 2.  Discuss
Pioneering technology stabilizes vaccines at all temperatures
June 8, 2020 -- Scientists have identified a new method called ensilication to prevent warmed-up vaccines from degrading. By coating proteins in a silica shell, the structures remain intact and effective. A new study published in Scientific Reports on June 8 expands on previous knowledge about the technique and provides crucial in situ and in vivo evidence for real-world applications.  Discuss
Preclinical innovations can speed COVID-19 drug development
June 5, 2020 -- Preclinical testing for drug candidates has remained largely unchanged, despite numerous innovations in cell culture techniques. Researchers discussed how these innovations could help speed drug discovery efforts for the COVID-19 pandemic in an article published in Theranostics.  Discuss
Spell-check gene editing corrects hearing loss in mice
June 4, 2020 -- Using a new genetic engineering technique called base editing, researchers restored genetic hearing loss in mice with a recessive point mutation. The research was published by a group from Boston Children's Hospital, the Broad Institute of the Massachusetts Institute of Technology, and Harvard University in Science Translational Medicine on June 3.  Discuss
Study reveals genomic similarity between SARS-CoV and SARS-CoV-2
June 3, 2020 -- A new technique has shown that conserved genetic sequences between SARS-CoV and SARS-CoV-2 may be important for their stability within host cells and ability to infect and replicate efficiently. The methodology was published in Biochemical and Biophysical Research Communications.  Discuss
Reverse genetics allows researchers to map SARS-CoV-2 in the body
June 2, 2020 -- A new study has revealed that SARS-CoV-2 infects the nasal cavity to the greatest degree and infects and replicates progressively less well in cells lower in the respiratory tract. The work, including the development of key laboratory tools, has been accepted by Cell.  Discuss
Multiple recombination events may have led to SARS-CoV-2 in humans
June 1, 2020 -- A team of scientists evaluating how SARS-CoV-2 jumped to humans found that several genetic recombination events made it especially well-suited to infect humans, according to a study published in Science Advances on May 29.  Discuss
FDA researchers describe lessons learned from COVID-19 immunology
May 29, 2020 -- Key immunological factors underlying the clinical stages of COVID-19 that could be targeted by therapeutic drugs were outlined in a review by U.S. Food and Drug Administration (FDA) researchers and published in Frontiers in Immunology on May 29.  Discuss
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