Cell Biology
NIH team creates 3D structure of twinkle protein, sheds light on mitochondrial diseases
Researchers from the National Institutes of Health (NIH) have used cryo-electron microscopy and other techniques to create a 3D structure of the twinkle protein, the final piece of the human minimal mitochondrial replisome to be structurally characterized. Read More
Molecular, genetic mechanisms of microglia predispose individuals to Alzheimer's: study
Mount Sinai researchers contend they have achieved an “unprecedented” understanding of the genetic and molecular mechanisms in human microglia, immune cells that reside in the brain, providing insights into how they contribute to the development and progression of Alzheimer’s disease. Read More
Link between genes, mitochondrial DNA reveals way to tackle cardiovascular disease
The discovery of a link between mitochondria, inflammation, and a pair of genes that help regulate blood cell growth has revealed a potential new target for atherosclerosis therapies. Read More
First full map of immune system connections unlocks drug discovery opportunities
Researchers have created the first full map of immune system connections showing how immune cells communicate, pointing to ways to modulate the pathways to treat cancer and infectious diseases. Read More
Technology restores cell, organ function in pigs an hour after their deaths
Yale University scientists were able to restore blood circulation and other cellular functions in pigs a full hour after their deaths from cardiac arrest by using technology that delivers a specially designed cell-protective fluid to organs and tissues, according to a paper published August 3 in the journal Nature. Read More
Adjuvanted liposomal vaccine protects baby mice from RSV, looks promising for human newborns
After a more than 50-year wait, a vaccine to protect infants from respiratory syncytial virus (RSV) -- the leading global cause of death in children under age five -- could finally become a reality. A single dose of an adjuvanted liposomal vaccine formulation has induced protection against RSV infection in baby mice. Read More
Google’s DeepMind, Chan Zuckerberg Biohub hail separate AI-scientific breakthroughs
DeepMind and the European Molecular Biology Laboratory-European Bioinformatics Institute have used artificial intelligence (AI) to predict the 3D structures of nearly all cataloged proteins, while a team of Chan Zuckerberg Biohub scientists has developed a machine-learning method to quantitatively analyze and compare microscopy images of proteins with no prior knowledge. Read More
Researchers identify T cells that protect against ischemic stroke in mice
University of Pittsburgh neurologists and immunologists have identified a subset of CD8+ regulatory-like T cells (CD8+TRLs) that provide fast-acting and lasting protection against ischemic stroke in mice, offering a potentially novel immunotherapy for stroke in humans. Read More
Map of brain changes in Alzheimer’s reveals potential target cell for drug therapies
A National Institute of Aging-backed project has released large-scale cellular and molecular information taken from more than 1.2 million neurons and other brain cells. Read More
Production technique clears barrier to widespread study of intestinal organoids
The aggregation of cells removes variability from the production of small intestinal organoids, clearing a major hurdle to the widespread use of the technologies as a research tool for studying the digestive system, according to a paper published July 28 in Stem Cell Reports. Read More
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