New technique could enable production of generic CAR T cells at scale
August 4, 2022 -- A Boston Children’s Hospital lab has developed a new method that could make chimeric antigen receptor (CAR) T-cell therapy more widely available using induced pluripotent stem cells to develop mature immune cells. Read More
Gene therapy shows promise in treating ALS in rodent models
August 2, 2022 -- A gene therapy, patented through the University of California, San Diego and the Department of Veterans Affairs measurably delayed disease onset in humanized mouse and rat models of familial amyotrophic lateral sclerosis (ALS). Read More
Scientists win $36.5M for cardiac gene editing therapy
August 1, 2022 -- An international team won 30 million pounds ($36.5 million U.S.) to develop cures for inherited heart muscle diseases that use ultra-precise gene therapy technologies to edit or silence the faulty genes that cause the conditions. Read More
Linus survey finds top two techniques or applications in life sciences R&D
July 29, 2022 -- A new survey of scientists finds that the top two techniques or applications in life sciences research and development (R&D) are CRISPR/cell-line engineering and artificial intelligence/machine learning-enabled bioinformatics when it comes to driving scientific advancements. Read More
Genes explain the effects of psychedelic drugs
July 28, 2022 -- Not everyone has the same response to psychedelic drugs and North Carolina researchers have figured out why -- seven genetic variants of one serotonin receptor greatly impact a certain serotonin receptor’s structure and function. Read More
CRISPR-based study identifies lung proteins that promote, protect against SARS-CoV-2 infections
July 27, 2022 -- A study led by University of California, Berkeley researchers has identified specific proteins within the human body that can either promote SARS-CoV-2 infections or protect against them, a discovery they contend could lead to new antiviral therapies. Read More
Soluble BCMA acts as decoy receptor to curb blood cancers in mice: study
July 27, 2022 -- A soluble version of B-cell maturation antigen (BCMA), a B-cell surface receptor, may act as a decoy to stop two proteins driving the growth of blood cancers, according to a new study by researchers at Stanford University. Read More
ARM, NIIMBL offer best practices, standards for cell therapy manufacturing challenges
July 26, 2022 -- The Alliance for Regenerative Medicine (ARM) and the National Institute for Innovation in Manufacturing BioPharmaceuticals (NIIMBL) have released best practices and a standard methodology intended to assist the cell-based therapy field with its ongoing manufacturing challenges. Read More
3D imaging reveals picture of T-cell activity to unlock solid tumor opportunity
July 26, 2022 -- Researchers have used imaging and transcriptomics to identify T cells with potent serial killing capacity in a push to expand use of the immunotherapies to solid tumors. Read More
Scientists discover new pathway to treat glioblastoma
July 25, 2022 -- Researchers have developed a biomimetic formulation using nanoparticles for lactate metabolism-based synergistic therapy to fight against the brain cancer glioblastoma multiforme. Read More
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