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CRISPR gene editing adapted for white blood cells
May 18, 2021 -- An adapted version of the CRISPR-Cas9 gene editing technique opens up the ability to manipulate human monocytes -- white blood cells that play vital roles in the immune system. The new study, published in Cell Reports on May 11, shows that the cells function normally following gene editing, allowing biologists to better understand how the cells interact with diseases like HIV. Read More
AI tracks cell movements in stem cell colonies
May 17, 2021 -- Scientists are still trying to understand how stem cell clusters assemble to form complex organs. To help demystify this phenomenon, researchers developed an ensemble of cell-tracking algorithms to track the movements in colonies of human induced pluripotent stem cells. The research demonstrates the potential of artificial intelligence (AI) in developmental biology. Read More
Quantitative image analysis provides confidence in drug development
May 14, 2021 -- Olga Kubassova, PhD, CEO of Image Analysis Group, spoke with ScienceBoard.net about how computational analysis is improving clinical trial imaging. Read More
Potential of gene editing for clinical use highlighted at ASGCT 2021
May 13, 2021 -- From base editing to in vivo CRISPR therapeutics and CRISPR-modified bacteriophages, scientists discussed innovations in preclinical research that have allowed them to advance these unique products to the clinic during a scientific symposium at the 2021 American Society of Gene & Cell Therapy (ASGCT) virtual meeting. Read More
Nobel Prize winner Doudna shares perspectives on future of CRISPR gene editing
May 12, 2021 -- Small science can translate into big discoveries, according to Nobel Prize laureate Jennifer Doudna, PhD. She discussed how her curiosity in understanding CRISPR led to the gene editing revolution in a talk at the 2021 American Society of Gene & Cell Therapy virtual meeting. Read More
Life science microscopy techniques get AI upgrade
May 11, 2021 -- Artificial intelligence (AI) can be used to speed up the computationally intensive process of light-field microscopy, a 3D microscopic imaging method. Researchers who developed the technique refer to it as hybrid LFM (HyLFM) and described the method in a paper published on May 7 in Nature Methods. Read More
Leveraging optofluidics to make therapeutic antibody discovery easier
May 10, 2021 -- The need for speed and accuracy in the development of therapeutic antibodies has prompted Berkeley Lights to upgrade its optofluidic tools to help customers improve the quality of their therapeutic antibody products. John Proctor, PhD, senior vice president of antibody therapeutics at Berkeley Lights, spoke with ScienceBoard.net about some technological advancements the company has recently launched. Read More
Preparation is key for postdocs to transition to industry positions
May 7, 2021 -- On-Demand Webinar -- Postdoctoral positions are a natural choice for many scientists who have just received their PhDs. Postdocs allow scientists to gain invaluable research experience and training under guided mentorship -- and potentially transition to industry jobs, explains Natalia Martin, PhD, a program manager at the American Chemical Society. Read More
Tiny mechanical forces can have a massive effect on T-cell activation
May 6, 2021 -- A new study reveals how tiny forces between T cells and their targets can help to jumpstart protective immune responses. Research published in Nature Communications on May 4 uses cutting edge microscopy techniques to track the association and dissociation between T cells and antigens. Read More
Hope for next-gen COVID-19 vaccines may rest in an unexpected region of the virus
May 5, 2021 -- Researchers further elucidated how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. The study, published in Science on May 4, describes how antibodies targeting sections of the virus outside of the receptor-binding domain may be useful in the development of vaccines and therapies. Read More
Life after academia: Industry can offer new opportunities for scientists
May 4, 2021 -- For many scientists working in academia, the idea of switching careers to industry can be intimidating. But many scientists are making the move and are finding corporate work to be just as rewarding. One of them is Anuraag Sarangi of medical communications firm Precisionscientia. Read More
Single-cell atlas of human teeth exposes root of stem cell behavior
May 3, 2021 -- The first comprehensive single-cell atlas of the human tooth reveals how different dental tissues control the activity of stem cells. Published recently in iScience, the study used advanced single-cell sequencing technology to show that changes in the cellular environment may explain differences in the behavior of stem cells. Read More
How one cell transplant platform is poised to tackle complex diseases
April 30, 2021 -- Lineage Cell Therapeutics CEO Brian Culley discusses the company's cell therapy technology with ScienceBoard.net. The technology involves the transplantation of differentiated stem cells as part of an off-the-shelf allogeneic cell therapy. Read More
How the South African SARS-CoV-2 variant evades antibodies
April 29, 2021 -- Computer modeling has demonstrated that one of the three mutations of the South African SARS-CoV-2 variant reduces its ability to bind to human cells. The results, published recently in the Journal of Medicinal Chemistry, also suggest that the mutation may help it escape some therapeutic antibodies. Read More
New method allows for study of genetic changes in individual DNA molecules
April 28, 2021 -- An improved sequencing method, called nanorate sequencing, allows for the study of genetic changes in human cells with unprecedented accuracy. The new technique, published in Nature on April 28, challenges the idea that cell division is the main mechanism driving genetic changes. Read More
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