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Help inform tools and technologies that advance research, treatments, and cures. The Science Advisory Board is an exclusive, online community that connects scientific and medical professionals across the world.

The Science Advisory Board is an exclusive, online community that connects scientific and medical professionals across the world.

New molecular drivers of Parkinson's disease identified
November 20, 2019 -- A group of researchers at the Icahn School of Medicine at Mount Sinai have discovered new molecular drivers of Parkinson's disease (PD) and subsequently determined how they impact the function of genes involved in the disease. This was accomplished using a complex statistical technique called multiscale gene network analysis (MGNA). The results were published in Nature Communications on November 20.  Discuss
Bacterial structures are critical to the development of new antibiotics
November 19, 2019 -- A research team from Cornell University have uncovered a unique regulatory mechanism unique to bacterial that may provide crucial insight for antibiotic targeting of pathogens. The work was published in Nature Structural & Molecular Biology on November 18.  Discuss
Researchers use drug repurposing to identify new treatment for Metabolic Syndrome
November 18, 2019 -- A research team from the University of Trento find a novel method for using old drugs in new ways, specifically for Metabolic Syndrome. This revolutionary technique, published on November 18 in Nature Communications, uses a systems biology approach to investigate deregulated biological processes and identify drug repurposing candidates.  Discuss
New mechanism elucidated for essential molecule-sorting organelle
November 15, 2019 -- A new study published in Nature Communications on November 15 suggests a new mechanism by which vesicles are transported out of the Golgi apparatus for the formation and maintenance of endosomes. The work, conducted by researchers from Tokyo University of Science and the Institute of Science and Technology in Austria, changes the paradigm of how materials are sorted and distributed once they enter cells.  Discuss
Genomic breakthrough in malaria research
November 15, 2019 -- An international consortium of researchers from the Institute of Cell Biology at the University of Bern and Umeå University in Sweden conducted a genome-wide deletion study to determine genes that are required for malaria parasite transmission. The results were presented in Cell on November 14.  Discuss
Single-molecule resolution technique allows researchers to quantify secondary transport
November 14, 2019 -- St. Jude researchers from Columbia University and New York State Psychiatric Institute present new evidence about the mechanics of how secondary active transporter proteins function. This report is published in Nature on November 13.  Discuss
New imaging technique gains an advantage with deep learning software
November 13, 2019 -- Researchers from Rensselaer Polytechnic Institute developed a new technique that applies deep learning to quantify images generated from fluorescence lifetime imaging. Details of the deep neural network they developed, called FLI-Net, are described in the November 12 issue of the Proceedings of the National Academy of Sciences.  Discuss
Is there a reproducibility problem with RNA-seq data?
November 12, 2019 -- Modern day technology has allowed scientists to analyze highly complex genomic data sets. However, with this comes increased challenges associated with reproducibility and misinterpretation of results from massive data sets. One such example, RNA sequencing (RNA-Seq), provides the ability to simultaneously measure gene expression levels of all genes in a sample in a single test.  Discuss
Targeted therapies can now be more effective with the use of ultrasound technology
November 12, 2019 -- Biomedical engineers from the University of Southern California in Los Angeles propose a new method to direct targeted drug release in the body using acoustics. The findings describing how they manipulated ultrasonic waves were published in Applied Physics Letters on November 12, 2019.  Discuss
Novel mitochondrial phenomenon helps explains early neurodegeneration
November 8, 2019 -- Northwestern University Feinberg School of Medicine scientists discovered a novel pathway that leads to neurodegeneration in amyotrophic lateral sclerosis (ALS). The study was published in Frontiers in Cellular Neuroscience on November 7. The pathway could explain the development of early stages of neurodegeneration which affects voluntary muscle movement such as walking and talking.  Discuss
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