Beckman Coulter, Sciex collaborate on high-throughput screening workflows
February 27, 2023 -- Life science analytical technologies company Sciex on Monday announced a collaboration with Beckman Coulter Life Sciences to provide comprehensive workflows for high-throughput screening; high-throughput absorption, distribution, metabolism, and excretion (HT-ADME); and synthetic biology studies. Read More
Data-driven modeling predicts hydrogel properties to accelerate biomedical research
January 31, 2023 -- Researchers have developed a data-driven modeling approach for predicting the properties of injected hydrogel blocks. Read More
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
March 17, 2023 -- A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity. Read More
Gene-editing reverses vision loss in mice
March 17, 2023 -- Researchers in China successfully restored the vision of mice with retinitis pigmentosa, a major cause of blindness in humans. The research, published Friday in the Journal of Experimental Medicine, describes a new form of CRISPR-based genome editing which has the potential to correct a variety of disease-causing genetic mutations. Read More
Stem cell-loaded plug improves outcomes in hard-to-treat Crohn’s disease patients
March 3, 2023 -- Most Crohn’s disease patients experienced complete clinical healing of perianal fistulas after treatment with a stem cell-loaded plug, according to data published in the journal Diseases of the Colon & Rectum. Read More
At SLAS 2023, companies showcase, launch advanced automation and screening technologies
February 28, 2023 -- At the Society for Laboratory Automation and Screening (SLAS) 2023 International Conference and Exhibition, being held in San Diego from February 25 to March 1, numerous firms have announced that they are showcasing emerging technologies for advanced life science applications. Read More
HIV potentially cured by transplanting umbilical cord stem cells in mixed race woman
March 16, 2023 -- Transplanting stem cells from umbilical cord blood has potentially cured a mixed-race woman of HIV and freed her from taking antiviral medication, according to a case report published in Cell. Read More
Therapeutic target may aid in glaucoma treatment
March 13, 2023 -- Indiana University School of Medicine researchers have identified a new therapeutic target that could lead to more effective glaucoma treatment. The research, published recently in Communications Biology, found that restoring mitochondrial homeostasis in diseased neurons can protect optic nerve cells from being damaged. Read More
Simpler, cheaper screening method developed to democratize COVID-19 drug discovery
March 15, 2023 -- An alternative method for finding single-chain antibodies has yielded COVID-19 drug candidates that may be effective against variants of concern. Read More
Long COVID less likely after Omicron than after original virus, Swiss researchers find
March 9, 2023 -- Swiss researchers have found that the Omicron variant of SARS-CoV-2 is much less likely to lead to long COVID than the original wild-type virus circulating at the start of the COVID-19 pandemic. Read More
Enzyme-activated drug candidate points to new way to treat liver cancer
March 14, 2023 -- Small molecules that are activated by an enzyme produced by some tumors could improve the treatment of liver cancer, a study run by scientists at the National Institutes of Health (NIH) and Massachusetts General Hospital suggests. Read More
GHIT Fund provides $1.9M for malaria drug development
March 14, 2023 -- The Global Health Innovative Technology (GHIT) Fund on Monday announced approximately $1.9 million (260 million yen) in funding for the research and development of a new malaria drug. Read More
Sophia Genetics partnering with Agilent Technologies to offer cancer analysis solution
March 15, 2023 -- Healthcare software firm Sophia Genetics said on Tuesday that it is partnering with Agilent Technologies to offer a comprehensive solution for cancer analysis. Read More
Correlation of enzyme to survival reveals potential target for metastatic solid tumors
March 10, 2023 -- The enzyme lysyl hydroxylase 1 (LH1) promotes the migration and metastasis of solid tumor cells and is associated with shorter survival, according to a recent study published in Molecular Cancer. Read More
Nasal antibody modulates inflammatory response in COVID-19 patients in small clinical trial
March 9, 2023 -- A nasally administered monoclonal antibody modulated inflammatory responses in COVID-19 patients in a small clinical trial. Read More
Immune homing mechanism enables targeted drug delivery to pediatric brain tumors in mice
March 2, 2023 -- Piggybacking on the homing mechanism that the immune system uses to direct white blood cells could enable the targeted delivery of drugs in children with brain tumors, according to research published on Thursday in Nature Materials. Read More
At SLAS 2023, BioAuxilium Research announces expansion of TR-FRET technology portfolio
March 1, 2023 -- BioAuxilium Research this week announced the expansion of its no-wash Thunder time-resolved Förster resonance energy transfer (TR-FRET) technology portfolio at the annual Society for Laboratory Automation and Screening (SLAS) International Conference and Exhibition in San Diego. Read More
Machine learning finds potential brain cancer drug targets in multi-omics dataset
February 2, 2023 -- Researchers have applied machine learning to a multi-omics dataset to identify the kinases that drive tumor growth and drug resistance in certain types of brain tumor. Read More
Scientists create cell atlas of developing human lung
December 9, 2022 -- Researchers from the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute, the Gordone Institute at the University of Cambridge, and collaborators have created a spatiotemporal cell atlas of the developing human lung. From the mapping, they have identified 144 cell states in the early stages of life and their interactions in new detail. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
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