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Single DNA strand cuts achieve safety and efficacy edge over CRISPR-Cas9 in fruit flies
July 5, 2022 -- CRISPR-Cas9 variants known as “nickases” that target a single DNA strand may increase the success rate of gene editing and reduce the risk of off-target mutations, according to a paper published in the journal Science Advances. Read More
NIH-funded research yields promising results for potential universal flu vaccines
July 1, 2022 -- A study funded by the National Institutes of Health (NIH) has shown that a new universal flu vaccine offers broad protection against different strains and subtypes of influenza A virus infections. Read More
Cell and gene therapy sector remains strong despite challenges: ARM CEO
June 30, 2022 -- The cell and gene therapy sector is “quite strong” despite the regulatory, investment, and manufacturing challenges facing the industry, according to Janet Lambert, CEO of the Alliance for Regenerative Medicine (ARM). Lambert spoke with ScienceBoard.net about developments in the industry. Read More
Machine learning model opens door to real-time detection of cell therapy contamination
June 30, 2022 -- Researchers at the Massachusetts Institute of Technology’s Singapore site have developed a new way to detect adventitious microbial contamination in mesenchymal stromal cell cultures. By using machine learning to predict if a culture is contaminated in near real-time, the approach could enable testing to take place during the production of cell therapy products. Read More
Beta cell gene deletion stops type 1 diabetes in mice, suggesting new way to prevent disease
June 29, 2022 -- Deleting a proinflammatory gene in the beta cells of pre-diabetic mice stops the development of type 1 diabetes, pointing to a potential way to prevent the condition, according to a study published on June 28 in the journal Cell Reports. Read More
Harnessing the power of chromatin science to target disease
June 29, 2022 -- ScienceBoard.net spoke with Martis Cowles, PhD, chief business officer at EpiCypher at the 2022 Biotechnology Innovation Organization International Convention about EpiCypher’s efforts to harness the power of chromatin science and provide insights into the chromatin regulatory system, which plays a critical role in many disease processes. Read More
Tokyo team challenges 10x Genomics with new single-cell RNA sequencing method
June 28, 2022 -- Researchers have developed a single-cell RNA sequencing method that is designed to tackle the cell sampling bias of existing techniques and deliver high-precision data, according to a paper published on June 27 in Nature’s Communications Biology journal. Read More
Machine Bio seeks to fundamentally change how biotechs make protein
June 27, 2022 -- Protein purification is one of the biggest bottlenecks for biotechnology companies. However, startup Machine Bio is developing a next-generation protein synthesis platform that can produce pure protein from DNA in hours, minutes, or continuously using a single step process. Founders David Marash and Jack Fernandes spoke with ScienceBoard.net at the 2022 Biotechnology Innovation Organization International Convention. Read More
How one CDMO is navigating the global supply chain disruption
June 24, 2022 -- The COVID-19 pandemic has disrupted supply chains and production schedules around the world, forcing contract development and manufacturing organizations (CDMOs) to adapt. In a video interview at the 2022 Biotechnology Innovation Organization International Convention, Federico Pollano of Rentschler Biopharma discussed how the company is navigating the worldwide supply chain disruption. Read More
A case study on partnering between patient advocacy organizations and biotech
June 23, 2022 -- Last week's 2022 Biotechnology Innovation Organization (BIO) International Convention in San Diego gave patient advocacy organizations and biotech companies the first opportunity in three years to meet in person with the potential for partnering. However, it was a meeting at BIO 2019 between CMT Research Foundation and DTx Pharma that could serve as a model for such partnerships. Read More
NIH seeks industry partners for technology transfer
June 23, 2022 -- The National Institutes of Health (NIH) is the world’s largest public funder of biomedical research. ScienceBoard.net spoke with Michael Salgaller of the National Cancer Institute at the 2022 Biotechnology Innovation Organization International Convention about NIH’s technology transfer professionals who work with its scientist inventors to find commercial partners to take their inventions to market. Read More
Estonia’s ambitious plans to grow its biotech industry
June 22, 2022 -- The Baltic state of Estonia's biotech industry is expected to grow tenfold this decade and offers significant opportunities for Estonian companies. ScienceBoard.net spoke with Andres Sutt, Estonia’s minister of entrepreneurship and information technology, at the 2022 Biotechnology Innovation Organization International Convention in San Diego about the country’s ambitious plans to grow its biotech industry. Read More
Fauna Bio leverages animal genomics, hibernation biology to target human diseases
June 21, 2022 -- Biotech company Fauna Bio is leveraging animal genomics and hibernation biology to develop novel translational therapeutics for disease prevention and reduce the impact of age-related diseases in humans. ScienceBoard.net spoke with co-founder and CEO Ashley Zehnder about the intersection of animal genomics, hibernation biology, and human diseases. Read More
Using the power of plants to develop novel biopharmaceuticals
June 21, 2022 -- Biologics manufacturing company iBio is using plants as bioreactors to develop and manufacture therapeutics and vaccines. ScienceBoard.net spoke with CEO Tom Isett at the 2022 Biotechnology Innovation Organization International Convention about the company’s technology, programs, and more. Read More
Apeiron Biologics' spinout invIOs targets solid tumors with novel cell therapy platform
June 20, 2022 -- Apeiron Biologics' spinout invIOs has a proprietary cell therapy platform for the modulation of intracellular immuno-oncology targets that enables rapid treatment of cancer patients using their own immune cells with short out-of-body time in out-patient settings. ScienceBoard.net spoke with invIOs’ CEO Peter Llewellyn-Davies at the 2022 Biotechnology Innovation Organization International Convention in San Diego. Read More
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