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Would infecting healthy people with SARS-CoV-2 speed the race to a vaccine?
July 2, 2020 -- Could the race to develop a vaccine for SARS-CoV-2 be sped up if researchers were able to study the virus in healthy individuals? And how could such research be conducted safely? These questions were covered in an article published July 1 in the New England Journal of Medicine.  Discuss
Faster fluid mixing could reduce costs for silica microparticles
July 1, 2020 -- A surprisingly simple approach to manufacturing silica nanoparticles by taking advantage of fluid dynamics in tiny Teflon tubes could reduce manufacturing costs. The work is described in a June 28 article published in the Chemical Engineering Journal.  Discuss
FDA issues guidance on COVID-19 vaccine licensure
June 30, 2020 -- The U.S. Food and Drug Administration (FDA) has provided new regulatory guidance for developers of vaccines for COVID-19. The guidance lays out the agency's current recommendations regarding the data needed to facilitate clinical development and licensure of vaccines to prevent COVID-19.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
June 30, 2020 -- To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
DNA 'origami' informs coronavirus vaccine design
June 29, 2020 -- Strategically folded DNA arranged to mimic viral antigens -- known as DNA "origami" -- may produce strong immune responses, according to a June 29 report in Nature Nanotechnology. Researchers are now working on adapting this approach for the development of a vaccine against SARS-CoV-2.  Discuss
Getting to the heart of SARS-CoV-2 protease; a main drug target
June 26, 2020 -- X-ray crystallography performed at room temperature of the main protease of SARS-CoV-2 may be more physiologically relevant than standard low-temperature x-ray structures, according to a June 24 report in Nature Communications.  Discuss
Computer tools shorten development time for SARS-CoV-2 drugs
June 25, 2020 -- Computer-based tools are helping researchers find potentially promising candidates for vaccines and treatments for SARS-CoV-2 -- and much more quickly than traditional approaches. Many of these software tools are described in an article published June 24 in Science Advances.  Discuss
Researchers discuss progress toward personalized cancer vaccines
June 24, 2020 -- Highly targeted and adaptable platforms allow researchers to develop cancer vaccines for a multitude of different cancer types and even create personalized vaccines for individual cancer patients. Researchers from BioNTech and the Wistar Institute shared exciting developments in cancer vaccines in a methods workshop during the American Association for Cancer Research 2020 virtual annual meeting II.  Discuss
Innovations in synthetic chemistry help identify new cancer therapies
June 23, 2020 -- The pathway to discovering and developing cancer therapies is not always linear, but well-designed models incorporating smart chemical innovations can provide elegant solutions to treatments for some of the most difficult cancers. Some of these efforts were shared on June 22 during the American Association for Cancer Research 2020 virtual annual meeting II.  Discuss
Next-generation sequencing reveals inherited mutations in young cancer patients
June 23, 2020 -- Researchers advocated for increased genomic surveillance in younger adult cancer patients with tumors that typically strike later in life, in a study presented at the American Association for Cancer Research 2020 virtual meeting, held June 22 to 24.  Discuss
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