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Biosimulation can mitigate risk of COVID-19 drug development
August 10, 2020 -- Drug development can be an expensive and tedious process. Add in the urgency of the COVID-19 pandemic, and you have a recipe for frustration. Biosimulation -- using computers to simulate drug response in humans -- can help accelerate the process, which Certara hopes to achieve with a new platform launched today targeted at COVID-19 vaccine development.  Discuss
COVID-19 vaccine based on peptide nanofibers shows promise
August 7, 2020 -- A new technology platform using self-assembling peptide nanofibers tagged with antibodies can be an effective SARS-CoV-2 vaccine, according to a proof-of-concept study published in Science Advances on August 7.  Discuss
Gum disease may affect COVID-19 severity
August 7, 2020 -- Patients with inflammation caused by periodontitis may experience more severe COVID-19 complications, according to an article published online July 30 in the Journal of the California Dental Association.  Discuss
Microbes shape antibodies prior to infection
August 6, 2020 -- Genetic analysis of antibodies reveals how microbes in the intestines impact overall B-cell populations and humoral responses to pathogens. The research was published in Nature on August 5.  Discuss
New COVID-19 vaccine candidate leverages earlier research
August 5, 2020 -- Could vaccine platforms developed for previous coronaviruses be converted to address the current COVID-19 pandemic? An August 5 report in Nature described how researchers leveraged previous vaccine research to develop mRNA-1273, a new SARS-CoV-2 vaccine candidate.  Discuss
Antiviral molecules targeting SARS-CoV-2 main protease are potent inhibitors
August 4, 2020 -- New compounds targeting the SARS-CoV-2 main protease could be potent inhibitors of the coronavirus. Researchers tested various engineered molecules for antiviral activity in an article published in Science Translational Medicine on August 3.  Discuss
Study analyzes how SARS-CoV-2 undermines immune defenses
August 3, 2020 -- A new research study used whole-genome sequencing to analyze the genetic profile of patients with the SARS-CoV-2 virus to gain more insight into how it turns the body's own immune system against itself. The findings could help researchers develop drugs to target the virus, according to an August 3 report in Nature Medicine.  Discuss
Researchers develop mouse model of COVID-19 infection
July 31, 2020 -- Researchers have generated a strain of SARS-CoV-2 that can infect mice and used it to produce a new mouse model of infection to help facilitate testing of COVID-19 vaccine candidates and therapies. The research article was published in Science on July 30.  Discuss
Researchers further define nonstructural protein targets of SARS-CoV-2
July 31, 2020 -- The crystal structure of nonstructural protein 16 of SARS-CoV-2, which plays a role in viral RNA capping to mimic host messenger RNA, reveals specific rational design targets that could be used to develop effective therapies against SARS-CoV-2 and other coronaviruses. The research was published in Nature Communications on July 24.  Discuss
Inhibiting SARS-CoV-2 papain-like protease may stop viral spread
July 30, 2020 -- Another nonstructural protein, papain-like protease, has been identified as a SARS-CoV-2 therapeutic target with the potential to block viral replication, according to an article published in Nature on July 29.  Discuss
Human-infecting coronaviruses have lived in bats for decades
July 29, 2020 -- Genome sequencing of the SARS-CoV-2 virus has revealed that the type of virus family to which the novel coronavirus belongs most likely first emerged in bats in the late 1960s, according to a new study published in Nature Microbiology on July 28.
Animal study turns in positive results for Moderna-NIH COVID-19 vaccine
July 29, 2020 -- Moderna's COVID-19 vaccine candidate, messenger RNA (mRNA)-1273, has been shown to induce immune responses and control upper and lower respiratory tract infection of rhesus macaques exposed to SARS-CoV-2, according to researchers from the U.S. National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases.  Discuss
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