Shenandoah expands cytokine, growth factors portfolio for cell and gene therapies
December 7, 2022 -- Shenandoah Biotechnology, a Fujifilm Irvine Scientific company, has announced the expansion of its CTGrade portfolio of cytokine and growth factors for cell and gene therapies that are manufactured following current good manufacturing practices. Read More
Sartorius BIA Separations, Exopharm team for large-scale exosome production
November 23, 2022 -- Bio-chromatography company Sartorius BIA Separations and medicine biopharmaceutical company Exopharm have signed a material transfer agreement in order to meet the demand of improved large-scale therapeutic exosome production and commercialization. Read More
Transcriptomics help visualize diffuse midline glioma
December 6, 2022 -- A Dana-Farber-led team used spatial single-cell transcriptomics to visualize diffuse midline glioma cancer cell structure across different age groups and locations. Their study, published December 5 in the journal Nature Genetics, provides insights that may facilitate new treatment approaches for this rare cancer. Read More
Mutated protein causes Parkinson's, protects against MSA
December 5, 2022 -- A single change in the misfolding protein that causes Parkinson's disease can protect against multiple system atrophy (MSA), University of Massachusetts Amherst scientists found. Read More
CIRM awards $8M for gene therapy research on rare, incurable diseases
December 2, 2022 -- The California Institute for Regenerative Medicine (CIRM) has awarded $8 million in grants for two research teams investigating gene therapy for rare and incurable diseases. Read More
Scientists uncover viral vectors that cross the blood-brain barrier
November 23, 2022 -- Using a "directed-evolution" strategy in mice and macaques, scientists at the Broad Institute of Massachusetts Institute of Technology and Harvard have identified adeno-associated viruses that cross the blood-brain barrier, advancing efforts to develop neurological disease gene therapies. Read More
New method detects 'buddy' proteins within cells
December 7, 2022 -- Researchers from University of Chicago’s Pritzker School of Molecular Engineering have developed a method to find proteins located in close proximity to each other inside a cell. The technology uses high-throughput genomic sequencing to measure proteins, protein complexes, and mRNA within individual cells. Read More
Glowing protein allows deeper looks at living tissues
December 7, 2022 -- Duke University and Albert Einstein College of Medicine researchers have designed a small fluorescent protein that absorbs and emits wavelengths of near-infrared light that penetrate deep into living tissue. Their technique, outlined December 1 in the journal Nature Methods, captures detailed high-resolution biomedical images. Read More
Vaccines offer long-term protection against severe COVID-19 in monkeys
December 2, 2022 -- New research indicates that two-dose experimental SARS-CoV-2 vaccines provide protection against COVID-19-related lung disease in year-old rhesus macaques vaccinated as infants. Read More
Estrogen receptors plus COVID-19 spike proteins cause coagulopathy
December 1, 2022 -- The SARS-CoV-2 spike protein interacts with the human estrogen receptor alpha in lung tissue and that may lead to severe coagulopathy. This process demonstrates the virus's varied impact based on sex and a path to improved vaccines, a team of U.S. and European researchers found. Read More
Rice University lab receives $3M grant to develop HIV treatment
December 6, 2022 -- Researchers from Rice University have been awarded a $3 million grant from the Bill & Melinda Gates Foundation to develop a once-a-year treatment for HIV and other infectious diseases. Read More
Researchers discover ‘QR code’ of GPCR protein couplings
December 6, 2022 -- Scientists from cancer research and treatment center City of Hope have identified how the G protein-coupled receptor (GPCR) works, which could further investigations of how the protein’s coupling with other proteins can impact how cells respond to medicines with fewer side effects. Read More
New method helps scientists identify efficient, tailored AI algorithms
December 6, 2022 -- Researchers from Cold Spring Harbor Laboratory have developed a new method designed to assist scientists in choosing artificial intelligence (AI) algorithms that best fit their needs. Their findings may help researchers in identifying more efficient AI programs to analyze the human genome. Read More
Researchers pinpoint gene leading to childhood glaucoma
December 5, 2022 -- A genetic mutation in the thrombospondin-1 gene leads to the development of severe childhood glaucoma and the discovery may improve disease screening and personalize treatments, a team of scientists has found. Read More
B cells hinder intestinal healing, offer potential IBD drug target
December 5, 2022 -- New research reveals that B cells, white blood cells that are critical to the proper functioning of the immune system, greatly increase after bowel damage and prevent the tissue from healing. The findings have implications for the treatment of inflammatory bowel disease (IBD). Read More
mRNA vaccines may help combat malaria
December 2, 2022 -- George Washington University-led research shows that COVID-19 fighting mRNA technology might save lives, prevent illness, and help eliminate malaria. Their study, published December 1 in the journal npj Vaccines, could usher in a new generation of malaria vaccines, the scientists contend. Read More
Mitochondria seen as common thread in autism spectrum disorder
November 28, 2022 -- Researchers in Canada have discovered previously unknown connections between genetic factors in autism spectrum disorder, specifically with the mitochondria. Read More
Researchers discover way to increase synthetic mRNA's protein production
November 23, 2022 -- A team of researchers from the Hong Kong University of Science and Technology has discovered a way to increase synthetic mRNA's protein production efficiency by up to 10 times. They contend that their findings can improve the effectiveness of mRNA vaccines and drugs with even less dosage of the mRNAs. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
December 1, 2022 -- A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer. Read More
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