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Optogenetic gene therapy provides hope for retinitis pigmentosa patients
July 26, 2021 -- Optogenetic therapy bypasses traditional methods of repairing defective photoreceptors in the eye by targeting other retinal cells. Recently, three examples of optogenetic therapeutics under development highlight many of the challenges this type of gene therapy faces for the treatment of a devastating genetic eye disease. Read More
Machine learning predicts if a COVID-19 clinical trial will be successful
July 23, 2021 -- Using machine learning, researchers have teased out the underlying factors of success for COVID-19 clinical trials, according to a PLOS One article published on July 12. The analysis showed that drug features and study keywords are the most informative features of COVID-19 trials. Read More
EMBL partners with DeepMind to predict 3D structure of human proteins
July 23, 2021 -- Google Health's DeepMind announced a partnership with the European Molecular Biology Laboratory (EMBL) to offer the scientific community open access to the most comprehensive database developed to date of predicted 3D protein structures. Read More
Cells sense repetitive mechanical forces through 'molecular clutch'
July 22, 2021 -- A phenomenon known as a "molecular clutch" allows cells in the body to detect the constant mechanical forces they experience, yet the mechanisms for this phenomenon are poorly understood. Now, in a study published recently in Nature Communications, researchers have shown that the frequency of forces can significantly alter the effect on cells. Read More
Google Cloud launches Healthcare Data Engine
July 22, 2021 -- Google Cloud announced the preview of Healthcare Data Engine, a tool for healthcare and life sciences organizations that integrates and standardizes data from multiple silos, including medical records, claims, clinical trials, and research data. Read More
Researchers fight drug-resistant bacteria with antibiotic 'Trojan horse'
July 21, 2021 -- In the latest chapter of the arms race between scientists and drug-resistant bacteria, scientists have devised an antibiotic-filled "Trojan horse" that penetrates deep into the patient's target tissues before unleashing an antibiotic payload on unsuspecting bacterial invaders. The methodology was described July 19 in eLife. Read More
Cellular programming spurs next-generation cell therapies
July 20, 2021 -- Cellular reprogramming of ex vivo cells may offer improvements on first-generation adoptive cell therapies, which have experienced limited clinical success due to complex manufacturing, potential patient rejection, and availability of clinical cell types. Further, in vivo reprogramming may expand on this concept by eliminating the need for manufacture and the risk of immune rejection. Read More
AI drug development startups raised $2.1B in 1st half of 2021
July 19, 2021 -- The market for artificial intelligence (AI) in drug development and discovery has been red-hot in recent years. The potential impact that AI can offer to human health and pharmaceutical development has grown in concert with the enabling technologies in computer processing and digitization, as well as new breakthroughs in machine-learning research. Ulrik Kristensen, PhD, of Emersion Insights offers a perspective. Read More
5 ways to improve the biomanufacturing workforce in regenerative medicine
July 16, 2021 -- A national survey of regenerative medicine biomanufacturing has revealed gaps in the training of skilled technical workers. The group behind the survey has proposed five steps to improve workforce quality and recently published its recommendations in Stem Cells Translational Medicine. Read More
Amazon announces availability of HealthLake cloud repository
July 16, 2021 -- Internet services giant Amazon Web Services has announced that its HealthLake cloud-based data repository is now available for use by healthcare and life sciences organizations. Read More
Iodine-activated nanoparticles trigger DNA damage in cancer cells
July 15, 2021 -- Newly designed nanoparticles containing iodine have been shown to kill cancer cells by causing DNA damage when activated by radiation. The in vitro findings were published in Scientific Reports on July 14. Read More
Thermo Fisher opens cGMP plasmid DNA manufacturing facility in Calif.
July 15, 2021 -- Thermo Fisher Scientific announced it has officially opened its new current good manufacturing practice (cGMP) plasmid DNA manufacturing facility in Carlsbad, CA, a step the company hopes will help it meet the rapidly growing demand for plasmid DNA-based therapies and vital mRNA-based vaccines. Read More
Swiss health data network fuels personalized medicine with data-sharing model
July 14, 2021 -- A nationwide data network has been built in Switzerland to support the exchange and reuse of health-related data produced in biomedical and clinical research settings. The strategy, which could serve as a model for how other countries can accelerate the development of personalized medicine, was recently described in an article in JMIR Medical Informatics. Read More
Cellares, Poseida partner on cell therapy manufacturing
July 14, 2021 -- Poseida Therapeutics has joined Cellares' Early Access Partnership Program to accelerate cell therapy manufacturing. The collaboration is expected to provide insight into CAR T workflows as well as other technologies. Read More
Gene therapy tackles 2 rare childhood diseases 2 different ways
July 13, 2021 -- Two new studies point to the efficient use of gene therapy to treat deadly childhood genetic diseases. The first study used direct gene therapy infusion to treat a rare neurodevelopmental disorder, while the second study used prenatal base editing in mouse models as proof of concept for the treatment of genetic diseases. These vastly different approaches show the promise of gene therapy for a variety of devastating diseases. Read More
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