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Inflammatory attack comes from an unexpected source in rheumatoid arthritis
February 26, 2020 -- Researchers have pinpointed immune cells called natural killer cells as an unexpected source of inflammatory proteins that contribute to rheumatoid arthritis. The research was published in the Journal of Experimental Medicine on February 25.  Discuss
Extra copies of chromosomes can be good or bad
February 25, 2020 -- Researchers are developing human cell lines to explore how extra copies of chromosomes can enhance the metastasis and invasiveness of cancer cells. They explained their methodology in a study published in Developmental Cell on February 24.  Discuss
New NIH study pinpoints how coronavirus attacks cells
February 24, 2020 -- The continued spread of the novel 2019 coronavirus, known as SARS-CoV-2, around the world has raised the need for a test to rapidly and efficiently screen coronaviruses to monitor rapid changes and determine how they function. Findings from ongoing U.S. National Institutes of Health (NIH) research, published in Nature Microbiology on February 24, offer new tools in the fight.  Discuss
3D magnetic cell culture transforms cancer therapy screening
February 21, 2020 -- Traditional high-throughput drug screening in oncology routinely relies on 2D cell models, which inadequately recapitulate the physiologic context of cancer. With recent technological advancements, a novel method for magnetic 3D cell culture can create pancreatic tumor models. This model may have serious effects on cancer research.  Discuss
Genomic landscape of osteosarcomas reveals why immunotherapy may not be effective
February 21, 2020 -- Immune profiling of osteosarcoma has revealed why immune checkpoint inhibitors might not be an effective treatment option for patients with this rare type of cancer, according to new research published online February 21 in Nature Communications.  Discuss
Artificial intelligence helps researchers find new antibiotics
February 20, 2020 -- To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find new potential antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing.  Discuss
Microscale flow chemistry uses 'switchable solvents' to improve extraction
February 19, 2020 -- New green technology enables accelerated screening and retrieval of "switchable" solvents for chemical and pharmaceutical applications. Utilizing microfluidic strategies, researchers developed an in situ approach to study gas-liquid processes in a time- and material-efficient manner. The work was published online in ACS Sustainable Chemistry and Engineering on February 6.  Discuss
Breakthrough in coronavirus research provides map for vaccines
February 19, 2020 -- Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Communication of cancer cells analyzed with organoids and novel cytometry
February 18, 2020 -- A new technique using organoids, self-organizing 3D tissue models, can decipher how individual cancer cells communicate with each other and the unique signals they create. This research, published in Nature Methods on February 17, could be used to help develop personalized cancer treatments in the future.  Discuss
Atomic structures revealed by cryo-EM may lead to new antiviral drugs
February 18, 2020 -- Using cryo-electron microscopy (cryo-EM), researchers found unique structures of paramyxoviruses that can lead to a better understanding of viral replication, which in turn can be leveraged to develop improved antiviral drugs. The details were published in the Proceedings of the National Academy of Sciences on February 17.  Discuss
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