Scientists manufacture malaria sporozoites without mosquitoes
December 8, 2022 -- Sanaria scientists have manufactured Plasmodium falciparum (Pf) sporozoites (SPZ) in vitro, enabling the critical, first breakthrough steps to scale up manufacturing of the PfSPZ malaria vaccine. Read More
Shenandoah expands cytokine, growth factors portfolio for cell and gene therapies
December 7, 2022 -- Shenandoah Biotechnology, a Fujifilm Irvine Scientific company, has announced the expansion of its CTGrade portfolio of cytokine and growth factors for cell and gene therapies that are manufactured following current good manufacturing practices. Read More
Machine learning used to encode commands for immune cells
December 9, 2022 -- Researchers at University of California San Francisco (UCSF), in collaboration with a team at IBM Research, have developed a virtual molecular library of thousands of “command sentences” for cells, based on combinations of “words” that guide engineered immune cells to seek out and kill cancer cells without pausing. Read More
Vegetables contain ‘garden variety’ cancer drugs
December 8, 2022 -- Polish scientists have revealed the potential for new cancer drugs formulated from nightshade plants (genus Solanum), including potatoes and eggplants. Read More
CIRM awards $8M for gene therapy research on rare, incurable diseases
December 2, 2022 -- The California Institute for Regenerative Medicine (CIRM) has awarded $8 million in grants for two research teams investigating gene therapy for rare and incurable diseases. Read More
Scientists uncover viral vectors that cross the blood-brain barrier
November 23, 2022 -- Using a "directed-evolution" strategy in mice and macaques, scientists at the Broad Institute of Massachusetts Institute of Technology and Harvard have identified adeno-associated viruses that cross the blood-brain barrier, advancing efforts to develop neurological disease gene therapies. Read More
Cellular nano-chamber directs tubulin protein folding: study
December 9, 2022 -- U.S. Department of Energy and Stanford University researchers have revealed how tiny cellular machines -- called chaperonins -- direct the folding of proteins into building blocks that provide essential cellular scaffolding and transport. Read More
Optogenetics-based tool manipulates neuron excitability
December 9, 2022 -- Harvard University and Massachusetts Institute of Technology researchers have devised a new technique to achieve long-term changes in neuron activity using light exposure. Their research, published on December 7 in the journal Science Advances, may help establish causality between neuron excitability and behavior, advancing the field of optogenetics. Read More
New drug 'fakes out' SARS-CoV-2 to neutralize it
December 8, 2022 -- A new drug neutralizes SARS-CoV-2 and its variants by acting as an ACE2 receptor decoy, Dana-Farber Cancer Institute researchers revealed. Read More
Vaccines offer long-term protection against severe COVID-19 in monkeys
December 2, 2022 -- New research indicates that two-dose experimental SARS-CoV-2 vaccines provide protection against COVID-19-related lung disease in year-old rhesus macaques vaccinated as infants. Read More
Rice University lab receives $3M grant to develop HIV treatment
December 6, 2022 -- Researchers from Rice University have been awarded a $3 million grant from the Bill & Melinda Gates Foundation to develop a once-a-year treatment for HIV and other infectious diseases. Read More
Researchers discover ‘QR code’ of GPCR protein couplings
December 6, 2022 -- Scientists from cancer research and treatment center City of Hope have identified how the G protein-coupled receptor (GPCR) works, which could further investigations of how the protein’s coupling with other proteins can impact how cells respond to medicines with fewer side effects. Read More
Salk Institute scientists identify oncogene activation
December 8, 2022 -- Researchers at the Salk Institute have zeroed in on the mechanisms that activate oncogenes, showing that genetic mutation activity depends on the distance between a particular gene and the sequences that regulate the gene. Read More
New method helps scientists identify efficient, tailored AI algorithms
December 6, 2022 -- Researchers from Cold Spring Harbor Laboratory have developed a new method designed to assist scientists in choosing artificial intelligence (AI) algorithms that best fit their needs. Their findings may help researchers in identifying more efficient AI programs to analyze the human genome. Read More
B cells hinder intestinal healing, offer potential IBD drug target
December 5, 2022 -- New research reveals that B cells, white blood cells that are critical to the proper functioning of the immune system, greatly increase after bowel damage and prevent the tissue from healing. The findings have implications for the treatment of inflammatory bowel disease (IBD). Read More
mRNA vaccines may help combat malaria
December 2, 2022 -- George Washington University-led research shows that COVID-19 fighting mRNA technology might save lives, prevent illness, and help eliminate malaria. Their study, published December 1 in the journal npj Vaccines, could usher in a new generation of malaria vaccines, the scientists contend. Read More
New method detects 'buddy' proteins within cells
December 7, 2022 -- Researchers from University of Chicago’s Pritzker School of Molecular Engineering have developed a method to find proteins located in close proximity to each other inside a cell. The technology uses high-throughput genomic sequencing to measure proteins, protein complexes, and mRNA within individual cells. Read More
Mitochondria seen as common thread in autism spectrum disorder
November 28, 2022 -- Researchers in Canada have discovered previously unknown connections between genetic factors in autism spectrum disorder, specifically with the mitochondria. Read More
Scientists create cell atlas of developing human lung
December 9, 2022 -- Researchers from the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute, the Gordone Institute at the University of Cambridge, and collaborators have created a spatiotemporal cell atlas of the developing human lung. From the mapping, they have identified 144 cell states in the early stages of life and their interactions in new detail. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
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