Sartorius BIA Separations, Exopharm team for large-scale exosome production
November 23, 2022 -- Bio-chromatography company Sartorius BIA Separations and medicine biopharmaceutical company Exopharm have signed a material transfer agreement in order to meet the demand of improved large-scale therapeutic exosome production and commercialization. Read More
NSF grant awarded to develop membrane purification platform
November 18, 2022 -- University of Kentucky researchers, in collaboration with the University of Arkansas and Clemson University, have received a $1.6 million National Science Foundation (NSF) grant to create a membrane purification platform for large-scale biomanufacturing of viral vectors and virus-like particles. Read More
NIH awards $3M grant to investigate Candida auris fungus treatment
December 1, 2022 -- The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), has awarded a five-year $3 million grant to Case Western Reserve University researchers to investigate the next level of treatment for Candida auris, a multidrug-resistant yeast that causes serious infection and, in some cases, death. Read More
Scientists uncover DNA repair mechanism, potential cancer target
December 1, 2022 -- Scientists from the Francis Crick Institute and biotech company Artios have revealed how polymerase theta, a DNA repair enzyme, becomes vital to certain cancers' survival when those cancer cells are unable to use a more common DNA repair method. Read More
CIRM awards $8M for gene therapy research on rare, incurable diseases
December 2, 2022 -- The California Institute for Regenerative Medicine (CIRM) has awarded $8 million in grants for two research teams investigating gene therapy for rare and incurable diseases. Read More
Scientists uncover viral vectors that cross the blood-brain barrier
November 23, 2022 -- Using a "directed-evolution" strategy in mice and macaques, scientists at the Broad Institute of Massachusetts Institute of Technology and Harvard have identified adeno-associated viruses that cross the blood-brain barrier, advancing efforts to develop neurological disease gene therapies. Read More
Scientists create lab-grown 3D organoid for gastroesophageal junction cancer
December 2, 2022 -- Researchers at Johns Hopkins Medicine have created a laboratory-grown 3D organoid model that is derived from human tissue to advance the understanding of how early stages of cancer develop at the gastroesophageal junction -- the point where the digestive system's food tube meets the stomach. Read More
Novel remote automation method for growing cerebral organoids
December 1, 2022 -- Researchers from University of California, Santa Cruz have developed a new automated, internet-connected microfluidics system that grows cerebral organoids. The process could lead to more effective pharmaceutical drugs that treat brain diseases. Read More
Vaccines offer long-term protection against severe COVID-19 in monkeys
December 2, 2022 -- New research indicates that two-dose experimental SARS-CoV-2 vaccines provide protection against COVID-19-related lung disease in year-old rhesus macaques vaccinated as infants. Read More
Estrogen receptors plus COVID-19 spike proteins cause coagulopathy
December 1, 2022 -- The SARS-CoV-2 spike protein interacts with the human estrogen receptor alpha in lung tissue and that may lead to severe coagulopathy. This process demonstrates the virus's varied impact based on sex and a path to improved vaccines, a team of U.S. and European researchers found. Read More
New approach facilitates natural products drug discovery
December 2, 2022 -- A new approach to natural products drug discovery integrates information from molecular biology, analytical chemistry, and bioinformatics to help address the current challenges of screening these products to identify potential drugs. Read More
New AI-based framework holds promise for drug discovery
December 1, 2022 -- Using the artificial intelligence (AI) method of convolutional neural networks, researchers in China developed a new framework for finding novel drug candidates. Read More
CRISPR-based tool cuts and pastes genes where needed
November 28, 2022 -- Massachusetts Institute of Technology researchers have designed a new CRISPR-based tool that can snip out faulty DNA sequences and safely replace them with new ones at desired cell sites. Read More
Sequencing project explores euglenoids' biotech potential
November 23, 2022 -- The Euglena International Network has launched a plan to sequence the genomes of all known euglenoid species over the next decade. Read More
mRNA vaccines may help combat malaria
December 2, 2022 -- George Washington University-led research shows that COVID-19 fighting mRNA technology might save lives, prevent illness, and help eliminate malaria. Their study, published December 1 in the journal npj Vaccines, could usher in a new generation of malaria vaccines, the scientists contend. Read More
Researchers discover new form of undetectable antimicrobial resistance
November 30, 2022 -- Australian researchers have discovered a new form of antimicrobial resistance that is undetectable using traditional testing methods. Their findings may help in the development of future antibiotics to tackle new mechanisms of antibiotic resistance. Read More
Mitochondria seen as common thread in autism spectrum disorder
November 28, 2022 -- Researchers in Canada have discovered previously unknown connections between genetic factors in autism spectrum disorder, specifically with the mitochondria. Read More
Researchers discover way to increase synthetic mRNA's protein production
November 23, 2022 -- A team of researchers from the Hong Kong University of Science and Technology has discovered a way to increase synthetic mRNA's protein production efficiency by up to 10 times. They contend that their findings can improve the effectiveness of mRNA vaccines and drugs with even less dosage of the mRNAs. Read More
Signal detection enables clear imaging of human cells
November 21, 2022 -- Beckman Institute researchers have developed an innovative method to clearly visualize the structure and chemical composition of a human cell. Read More
New computational method maps architecture of human tissues in unprecedented detail
October 31, 2022 -- Weill Cornell Medicine researchers have developed a new computational method to map the architecture of human tissues in unprecedented detail, with the potential to accelerate studies on organ-scale cellular interactions and enable powerful new diagnostic strategies for an array of diseases. Read More
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