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3D magnetic cell culture transforms cancer therapy screening
February 21, 2020 -- Traditional high-throughput drug screening in oncology routinely relies on 2D cell models, which inadequately recapitulate the physiologic context of cancer. With recent technological advancements, a novel method for magnetic 3D cell culture can create pancreatic tumor models. This model may have serious impacts on cancer research.  Discuss
Genomic landscape of osteosarcomas reveals why immunotherapy may not be effective
February 21, 2020 -- Immune profiling of osteosarcoma has revealed why immune checkpoint inhibitors might not be an effective treatment option for patients with this rare type of cancer, according to new research published online February 21 in Nature Communications.  Discuss
Artificial intelligence helps researchers find new antibiotics
February 20, 2020 -- To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find potential new antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing.  Discuss
Microscale flow chemistry uses 'switchable solvents' to improve extraction
February 19, 2020 -- New green technology enables accelerated screening and retrieval of "switchable" solvents for chemical and pharmaceutical applications. Utilizing microfluidic strategies, researchers developed an in situ approach to study gas-liquid processes in a time- and material-efficient manner. The work was published online in ACS Sustainable Chemistry and Engineering on February 6.  Discuss
Breakthrough in coronavirus research provides map for vaccines
February 19, 2020 -- Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Communication of cancer cells analyzed with organoids and novel cytometry
February 18, 2020 -- A new technique using organoids, self-organizing 3D tissue models, can decipher how individual cancer cells communicate with each other and the unique signals they create. This research, published in Nature Methods on February 17, could be used to help develop personalized cancer treatments in the future.  Discuss
Atomic structures revealed by cryo-EM may lead to new antiviral drugs
February 18, 2020 -- Using cryo-electron microscopy (cryo-EM), researchers found unique structures of paramyxoviruses that can lead to a better understanding of viral replication, which in turn can be leveraged to develop improved antiviral drugs. The details were published in the Proceedings of the National Academy of Sciences on February 17.  Discuss
Scientists see through human organs for the 1st time
February 14, 2020 -- For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.  Discuss
Genetically engineered probiotics successfully deliver immunotherapies
February 13, 2020 -- A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine.  Discuss
Phages containing huge amounts of DNA are found around the globe
February 12, 2020 -- An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes.  Discuss
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