Immunology
New nanoparticles help reduce inflammatory disease
Researchers from Washington State University have discovered a potential new treatment option for diseases associated with inflammation. The study, published in Science Advances on November 6, describes a new patent-pending nanotechnology that specifically targets activated neutrophils that compromise the immune system.  Discuss
Orphan immunity gene clusters acquired for protection
Researchers from the University of Washington School of Medicine and Howard Hughes Institute found that gut bacteria acquire interbacterial defense gene clusters. The October 30 article in Nature, suggests that bacteria use these toxins against their microbial neighbors. This discovery could further scientific knowledge of the human gut which is critical to many aspects of health and disease.  Discuss
Better flu treatments on the way thanks to the discovery of broadly protective antibodies
Research from the National Institutes of Allergy and Infectious Diseases (NIAID) isolated the antibodies from a person sick with the flu five days after onset. They isolated antibodies that bind to neuraminidase (NA) proteins on the surface of influenza viruses, which provided broad protection against several different strains of influenza both in vitro and in vivo. The researchers provided characterization details in the October 25 issue of Science.  Discuss
New insights into why tumor suppressor proteins go awry in cancer
Researchers from Stowers Institute for Medical Research in Kansas City, MO have identified proteins that are involved in tumor growth and metastasis in many cancers such as breast cancer. The research was published in Science Advances on October 23.  Discuss
Night gardeners: Microglia involved in brain plasticity during sleep
Research from the University of Rochester Medical Center (URMC) suggests that specific immune cells called microglia – which play a crucial role in reorganizing connections between nerve cells, fighting infection, and repairing damage – are primarily active during sleep. The research, conducted on mouse models, was published in Nature Neuroscience on October 21.  Discuss
Scientists elucidate the genetic impact of host immune system on the microbiome
Researchers at the University of Chicago conducted research that suggests that the genetic differences in the immune system contribute to bacterial colonization of gut. The findings, published in Cell Reports on October 15, uses a new approach to determine the genetic influence of the immune system on the microbiome of mice.  Discuss
Large-scale study finds genetic variant responsible for detrimental immune response to common anti-inflammatory drugs
Researchers in the UK seek to understand why commonly used medication fails to treat Chron's disease by identifying a new genetic marker. The research published in Gastroenterology on October 7, identified a genetic variation that decreases the efficiency of anti-tumor necrosis factor (anti-TNF) drugs.
Personalized cancer vaccines now possible due to discovery of cancer frameshift neoantigens
Researchers from Arizona State University's Biodesign Institute demonstrated experimental proof-of-concept that cancer mutations produce individual neoantigens, or newly formed antigens, and can be used for cancer vaccines. The new paper published in Scientific Reports on October 2, shows that neoantigens can be used to protect against cancer.  Discuss
Super-resolution imaging characterizes individual synaptic proteins
It is now possible to rapidly image synaptic proteins at high-resolution thanks to a new technique developed by researchers at MIT and the Broad Institute of Harvard. Details of the technique which use fluorescent nucleic acid probes to label different proteins are described the September 26 Nature Communications article.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
Conferences
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
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