Immunology
Combo of CRISPR, informatics helps uncover genetic regulators of immune cells
A new computational tool that uses CRISPR and multimodal single-cell sequencing data can provide insights into the function and regulation of human genes. The study, published in Nature Genetics on March 1, provides details on the molecular regulation of immune checkpoint inhibitors. Read More
Janssen COVID-19 vaccine becomes 3rd authorized in U.S.
Janssen Biotech's COVID-19 vaccine has received an emergency use authorization from the U.S. Food and Drug Administration. The move allows the vaccine to be distributed in the U.S. for the prevention of COVID-19 caused by SARS-CoV-2 in individuals 18 years of age or older. Read More
FDA committee gives nod to Janssen COVID-19 vaccine
A single-shot COVID-19 vaccine from Johnson & Johnson's Janssen Biotech subsidiary has received a positive recommendation from a U.S. Food and Drug Administration (FDA) advisory committee. Should the FDA grant the product emergency use authorization, the vaccine candidate will become the third to be made available in the U.S. Read More
New open-access toolkit helps research labs study SARS-CoV-2
One of the most important factors in fighting the COVID-19 pandemic is large-scale scientific collaborations and knowledge sharing. One international group of researchers has made its simple, robust toolkit available to laboratories around the globe that are unaccustomed to working with coronaviruses. The details can be found in a PLOS Biology paper published on February 25. Read More
Clinical pipeline promises effective 2nd-generation COVID-19 vaccines
Despite the small number of COVID-19 vaccines that have been granted emergency use authorizations by the U.S. Food and Drug Administration to date, many biopharmaceutical companies are continuing to push new vaccine candidates toward regulatory approval. The slow rollout of approved vaccines has created the need for second-generation products with the potential to accelerate the world's return to something approaching normalcy. Read More
The next generation of COVID-19 vaccines: Gallo on next steps
What will the next generation of COVID-19 vaccines look like? In the first of a two-part series, The Science Advisory Board spoke with pioneering virology researcher Dr. Robert Gallo to get his thoughts on what a next-generation COVID-19 vaccine might look like, and which candidates are in the running for marketing authorization. Read More
mRNA vaccines are successful for COVID-19. But what about cancer?
Advances in platform technology for the development of messenger RNA (mRNA) vaccines have led to the authorization of several COVID-19 vaccines. But scientists are also working on developing mRNA vaccines to protect against or treat other diseases, such as cancer. This includes a hydrogel-based RNA vaccine, the design of which is discussed in an article published in Nano Letters on February 1. Read More
Proteomics helps researchers pick the best anti-SARS-CoV-2 nanobodies
A new high-throughput proteomics-based strategy to identify tiny antibody fragments -- called nanobodies -- may provide an efficient and effective method for developing therapeutics against the deadly SARS-CoV-2 virus -- including variants. The findings were published in Cell Systems on February 15. Read More
Scientists identify missing molecular links to SARS-CoV-2, host interactions
Researchers have identified interactions between short viral proteins and receptors that facilitate the entry of the SARS-CoV-2 virus into a host. This evidence of molecular links, published in Science Signaling on February 12, may help scientists identify drugs that are highly effective at blocking the virus. Read More
Multiomics approach profiles molecular characteristics of glioblastoma
A team of more than 40 investigators has created a profile of the genes, proteins, infiltrating cells, and signaling pathways of the deadly brain cancer glioblastoma. The findings could lead to better patient care, according to the authors of a new study published February 11 in Cancer Cell. Read More
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