Taking metformin during SARS-CoV-2 infection cuts risk of long COVID in clinical trial
People who took the diabetes drug metformin after being infected with SARS-CoV-2 were less likely to develop long COVID in a randomized clinical trial. Read More
Foundation Medicine enters companion diagnostic collaboration with Merck KGaA
Foundation Medicine said Monday that it has entered a strategic collaboration with Merck KGaA in Darmstadt, Germany to develop FoundationOne Liquid CDx and FoundationOne CDx as companion diagnostics in the U.S. market for selected marketed and pipeline treatments. Read More
FDA updates recommendations to modernize design, conduct of clinical trials
The U.S. Food and Drug Administration (FDA) on Tuesday released a draft guidance document with updated recommendations for good clinical practices aimed at modernizing the design and conduct of clinical trials. Read More
Metagenomics study finds antibiotic resistance genes are widespread among bacteria
Genes that make bacteria resistant to antibiotics are more widespread in our environment than was previously realized. Read More
NIH initiative to test new cancer drug combinations
The National Institutes of Health’s (NIH’s) National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of new cancer drug combinations, guided by tumor biology. The initiative, called Combination Therapy Platform Trial with Molecular Analysis for Therapy Choice (ComboMATCH), aims to identify promising treatments that can then advance to larger, more definitive clinical trials. Read More
Cryo-electron microscopy sheds light on key step in replication of SARS-CoV-2
Researchers have used cryo-electron microscopy (cryo-EM) to visualize a critical step in the replication of SARS-CoV-2, generating insights that could inform the development of COVID-19 drugs. Read More
HIV nanoparticle vaccine induces strong T-cell responses in early-phase clinical trial
An HIV nanoparticle vaccine has induced strong T-cell responses in a first-in-human clinical trial, marking a step toward the development of a product that protects against the virus. Read More
New antibiotic targets deadly hospital superbug
Scientists used artificial intelligence (AI) to discover a promising antibiotic that may help doctors target Acinetobacter baumannii, a deadly, drug-resistant pathogen that often strikes vulnerable hospital patients. The study, published Thursday in the journal Nature Chemical Biology, identified the antibacterial compound abaucin in response to the urgent need for new ways to treat A. baumannii infection. Read More
Study of woman who cannot feel pain finds molecular explanation for phenomenon
Researchers have uncovered the biological effects of a mutation that causes its carrier to live virtually pain-free, heal more rapidly, and experience reduced anxiety and fear. Read More
Modified anti-nausea drug enters cells, treats pain
Altering the chemical properties of the anti-nausea drug netupitant enables it to enter interior cell compartments and provide long-lasting pain relief, according to research published Monday in the Proceedings of the National Academy of Sciences (PNAS). Read More
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