Nobel Prize winner Doudna shares perspectives on future of CRISPR gene editing
Small science can translate into big discoveries, according to Nobel Prize laureate Jennifer Doudna, PhD. She discussed how her curiosity in understanding CRISPR led to the gene editing revolution in a talk at the 2021 American Society of Gene & Cell Therapy virtual meeting. Read More
Preparation is key for postdocs to transition to industry positions
Postdoctoral positions are a natural choice for many scientists who have just received their PhDs. Postdocs allow scientists to gain invaluable research experience and training under guided mentorship -- and potentially transition to industry jobs, explains Natalia Martin, PhD, a program manager at the American Chemical Society. Read More
Tiny mechanical forces can have a massive effect on T-cell activation
A new study reveals how tiny forces between T cells and their targets can help to jumpstart protective immune responses. Research published in Nature Communications on May 4 uses cutting edge microscopy techniques to track the association and dissociation between T cells and antigens. Read More
Single-cell atlas of human teeth exposes root of stem cell behavior
The first comprehensive single-cell atlas of the human tooth reveals how different dental tissues control the activity of stem cells. Published recently in iScience, the study used advanced single-cell sequencing technology to show that changes in the cellular environment may explain differences in the behavior of stem cells. Read More
How the South African SARS-CoV-2 variant evades antibodies
Computer modeling has demonstrated that one of the three mutations of the South African SARS-CoV-2 variant reduces its ability to bind to human cells. The results, published recently in the Journal of Medicinal Chemistry, also suggest that the mutation may help it escape some therapeutic antibodies. Read More
New tool sheds light on transient protein interactions in cells
Researchers have developed a novel chemical tool for elucidating protein interaction networks within cells. The technique, details of which were published in Molecular Cell on April 23, allows for the visualization of protein-protein interactions. Read More
Naturally occurring molecule helps SARS-CoV-2 evade neutralizing antibodies
Researchers have identified naturally occurring molecules that are created from the breakdown of hemoglobin and block the binding of a subset of human antibodies to SARS-CoV-2. The discovery, published in Science Advances on April 22, may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus. Read More
Cell-free technique could enable on-demand vaccine production
A new cell-free synthetic biology technique that increases the volume of membrane components in the manufacture of conjugate vaccines can significantly improve the efficiency of vaccine production, according to a new method published in Nature Communications on April 22. The technology could enable on-site production of vaccines and therapies, enabling them to be more efficiently distributed in areas where they are most needed. Read More
Scientists map gene expression without microscopes
A new framework called Tomographer, which uses sequencing data from tissues cut into thin strips in a way that allows them to be reconstructed, has been developed to spatially resolve gene expression data without the need for a microscope. The work was published in Nature Biotechnology on April 19. Read More
New algorithm helps integrate single-cell data from around the globe
A new algorithm enables researchers from around the globe to integrate multiple single-cell datasets from a variety of omics platforms in a quick and efficient process that can be done on standard computers. The technology, described in an April 19 Nature Biotechnology article, will help speed collaborative cell cataloging projects, such as the Human Body Map and Human Cell Atlas. Read More
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