Genomics
Virtual framework provides unprecedented detail of the heart
Researchers have created a comprehensive map of cardiac neurons at the cellular scale that allows for gene expression data to be superimposed, giving insight into the functional roles of specific neuron clusters. The work was published in iScience on May 26.  Discuss
New platform includes biological similarities to accelerate drug discovery
A new open-access tool provides information on the effects of nearly 1 million compounds in a wide range of biological settings. The new tool, published in Nature Biotechnology on May 18, may change the drug discovery process by moving beyond reliance on chemical information alone.  Discuss
Academic lab quickly converts to perform SARS-CoV-2 testing
Academic labs could be converted to perform clinical work and process SARS-CoV-2 diagnostic assays with rapid turnaround times to meet increased demand for testing during the COVID-19 pandemic. Investigators from Boston University and Boston Medical Center provided an outline of how they adapted a lab in an article published online May 10 in Med.  Discuss
Moving closer to orally dosed peptide medications
A new method can identify among billions of double-bridge peptides the ones that are most likely to bind to disease targets of interest and escape enzymatic degradation in the gastrointestinal tract. A study on the method was published in Nature Biomedical Engineering on May 11.  Discuss
Pangolin genome offers insight into SARS-CoV-2's jump to humans
Research into the source of SARS-CoV-2 in China has focused on pangolins, anteater-like mammals that may have harbored the virus before it jumped to humans. New findings published May 8 in Frontiers in Immunology indicate pangolins may lack two virus-sensing genes, making them more susceptible to being carriers of coronaviruses.  Discuss
Genomic tools help researchers understand how SARS-CoV-2 is evolving
A new study has identified nearly 200 recurrent genetic mutations in the SARS-CoV-2 virus, according to research published as a preproof in Infection, Genetics and Evolution on May 5. The findings could offer clues to how the virus is adapting and evolving in humans and lead to optimal drug and vaccine targets.  Discuss
An update on RNA extraction kit supply due to COVID-19
The extraordinary demand for COVID-19 polymerase chain reaction testing has strained the production capabilities of vendors in the nucleic acid preparation market. Several vendors are reporting skyrocketing demand for RNA extraction kits and other COVID-19-related products.  Discuss
COVID-19: A double-edged sword for the pharma industry
The COVID-19 pandemic is causing major disruptions to pharmaceutical R&D activities, despite the pressing need for treatments and diagnostics for the novel coronavirus. In a new article, Ivan Gandayuwana of Strategic Directions International examines the multiple impacts COVID-19 is having on pharma.  Discuss
Bringing order to the viral multiverse
A new taxonomic classification system for viruses has been proposed by the International Committee on Taxonomy of Viruses, the group that oversees the official classification of viruses and naming of taxa. A consensus statement on the proposal appears in Nature Microbiology.  Discuss
Experts discuss promising strategies for tackling SARS-CoV-2
What's the best strategy for developing treatments for the SARS-CoV-2 virus? The most promising approaches for a rapid response are antivirals and gene therapy, according to a new review article published April 24 in Frontiers in Microbiology.  Discuss
Conferences
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International Europe
July 13-16
Amsterdam, Noord-Holland Netherlands
Bioprocess International West
August 10-13
Santa Clara, California United States
General Discussion
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