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Animal study turns in positive results for Moderna-NIH COVID-19 vaccine
July 29, 2020 -- Moderna's COVID-19 vaccine candidate, messenger RNA (mRNA)-1273, has been shown to induce immune responses and control upper and lower respiratory tract infection of rhesus macaques exposed to SARS-CoV-2, according to researchers from the U.S. National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases.  Discuss
Genetic regulation of immune diseases starts at birth
July 28, 2020 -- Areas of the human genome may explain the early origins of chronic immune and inflammatory diseases that develop later in life, according to a study published in Nature Communications on July 28.  Discuss
Imaging finds tooth decay's root, may lead to ways to fight it
July 28, 2020 -- Atom probe tomography and other techniques revealed that human enamel contains small chemical flaws that may affect the resiliency of the fundamental building blocks of teeth, in a study published July 2 in Nature.  Discuss
SARS-CoV-2 envelope protein identified as target for antiviral drugs
July 27, 2020 -- Comparison of the SARS-CoV-2 genome with other betacoronaviruses can provide useful information on how drugs targeting other coronaviruses may improve outcomes for COVID-19 patients. The analysis was presented in a July 27 Frontiers in Cellular and Infection Microbiology article.  Discuss
SARS-CoV-2 disguises its own genetic material to facilitate infection
July 24, 2020 -- The SARS-CoV-2 virus is able to camouflage itself to promote viral replication, as revealed by structural details of proteins on the surface of the virus. Researchers discovered an enzyme that they believe could be an important target for antiviral drug development, according to a July 14 Nature Communications report.  Discuss
New tools rapidly detect anti-SARS-CoV-2 antibodies
July 23, 2020 -- New tools using surrogate viruses may be useful for rapid testing to determine whether antibodies effectively neutralize SARS-CoV-2. The viral vector-based platform approach was published in the Journal of Experimental Medicine on July 21.  Discuss
Addressing the COVID-19 challenge with computer modeling & simulation
July 23, 2020 -- Each day, we wake up hoping for positive news about vaccines and therapies to combat COVID-19. More than 70 candidate molecules are being evaluated for repurposing to treat COVID-19. This number will grow thanks to the use of new combination therapies discovered under an aggressive, disciplined, and quantitative approach to evaluating candidates called model-informed drug development.  Discuss
Shape-shifting may provide coronavirus with a survival advantage
July 22, 2020 -- Conformational changes of the SARS-CoV-2 spike protein -- the target of many vaccines and therapies -- may have features that help the virus hide from the host immune system and survive longer in the environment, according to a study published in Science on July 21.  Discuss
Replicating RNA COVID-19 vaccine shows robust responses in early testing
July 21, 2020 -- A replicating RNA vaccine delivered with a lipid-based nanoparticle emulsion has been shown to produce potent antibodies against SARS-CoV-2 in mice and primates with a single immunization, according to a study published in Science Translational Medicine on July 20.  Discuss
Transarterial chemoperfusion shows promise in mesothelioma patients
July 21, 2020 -- According to research presented during a recent virtual session of the Society of Interventional Radiology, there has been progress on a novel treatment for patients with advanced mesothelioma.  Discuss
SARS-CoV-2 Nsp1 protein effectively blocks host antiviral defenses
July 20, 2020 -- A SARS-CoV-2 protein, Nsp1, may play a critical role in weakening antiviral innate immune defenses, according to a study published in Science on July 17. Researchers identified how the viral protein specifically shuts down host protein production and subsequently blocks host immune functions.  Discuss
Red blood cells offer potential to deliver vaccines
July 17, 2020 -- Scientists have developed a biomimetic vaccine-delivery strategy based on an innate immune function of red blood cells that can deliver vaccine nanoparticles to the spleen, according to a research article published in the Proceedings of the National Academy of Sciences on July 14.  Discuss
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