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Improving the safety of gene therapies 2 different ways
November 12, 2020 -- Two groups of researchers have developed unique approaches to overcome the limitations of delivery of gene editing therapeutics. In a pair of new papers, researchers describe methods for more efficient and safe delivery of CRISPR components to targeted cells and tissues. Discuss

Digital microfluidic technique connects cells to their environment
November 11, 2020 -- A new digital microfluidic technique allows researchers to connect physical cell properties with the molecular makeup of individual cells. This new approach, published in Nature Communications on November 11, will enable a deeper study of stem cells and other rare cell types for therapeutic development. Discuss

Can vaccine resistance be predicted with test samples?
November 10, 2020 -- The likelihood of SARS-CoV-2 developing resistance to COVID-19 vaccines currently under development can be determined using repurposed blood and nasal test samples that are already being collected as part of clinical trials, according to Pennsylvania State University researchers. The perspective piece was published in PLOS Biology on November 9. Discuss

If successful, COVID-19 vaccines could be worth $27B
November 9, 2020 -- Vaccines are considered one of the most effective public health measures preventing diseases in the modern world. They could also be very profitable endeavors, according to a new report from Kalorama Information, which estimates the market for COVID-19 vaccines could be as high as $27 billion. Discuss

RNA interactions may hold key to drugs targeting SARS-CoV-2
November 9, 2020 -- Researchers have unearthed how the SARS-CoV-2 virus employs genomic "origami" to infect and replicate inside host cells, a discovery that may hold the key to developing novel antiviral drugs that target specific areas of the virus's genomic structure. The findings were published on November 5 in Molecular Cell. Discuss

Canadian experts discuss somatic gene therapy approval and use
November 6, 2020 -- Gene therapies offer great benefits to patients but could strain healthcare budgets and exacerbate existing treatment inequities in Canada, according to an expert panel that was commissioned to write a report by the Council of Canadian Academies. Discuss

Different immune response helps kids clear SARS-CoV-2 quickly
November 6, 2020 -- Why does the SARS-CoV-2 virus seem to have less of an impact on children than adults? A new study published November 5 in Nature Immunology investigates this question, finding that the immune systems of children respond differently to SARS-CoV-2 in a way that allows them to more easily clear the virus from their bodies. Discuss

Proteomic changes in cancer cells provide new drug insights
November 5, 2020 -- Large-scale profiling of protein changes in response to drug treatment in cancer cell lines has been demonstrated as a powerful tool to predict drug sensitivity, understand drug resistance, and identify optimal drug combinations. The analysis was published in Cancer Cell on November 5. Discuss

Synthetic nanobodies show potential for new COVID-19 therapies
November 4, 2020 -- Synthetic nanobodies may provide a practical avenue for the development of novel COVID-19 therapies compared to human antibodies, which are bulkier and require greater research investment. A study on synthetic nanobodies was conducted by a group of German researchers and published in Nature Communications on November 4. Discuss

Gene silencing target identified as possible leukemia treatment
November 3, 2020 -- Researchers have identified a molecule that permits growth of cancers such as leukemia by silencing certain host genes. The results, published in Nature Genetics on November 2, challenge the current understanding of epigenetic control during tumor development. Discuss

Are SARS-CoV-2 mutations more contagious than the original virus?
November 2, 2020 -- The SARS-CoV-2 virus has accumulated genetic mutations that may make it more contagious and more easily spread in metropolitan communities, according to researchers who analyzed over 5,000 COVID-19 patient samples in the Houston area. They published their results in mBio on October 30. Discuss

Effectiveness of COVID-19 vaccines will rely on public trust
October 30, 2020 -- No matter how effective upcoming COVID-19 vaccines are, their ultimate success in combating the pandemic will depend on how much the public trusts the safety and efficacy of the products. That's according to a panel of physicians and scientists who discussed COVID-19 vaccine trials in a briefing on October 29. Discuss

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