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Nanoparticles may offer new way to tackle antibiotic-resistant bacteria
April 26, 2021 -- A team of researchers has developed nanoparticles that use a completely different mode of action from conventional antibiotics. These inorganic nanoparticles have inherent antimicrobial properties and can target pesky bacteria that hide inside of cells. The results were published in Nanoscale on April 22. Read More
Naturally occurring molecule helps SARS-CoV-2 evade neutralizing antibodies
April 23, 2021 -- Researchers have identified naturally occurring molecules that are created from the breakdown of hemoglobin and block the binding of a subset of human antibodies to SARS-CoV-2. The discovery, published in Science Advances on April 22, may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus. Read More
Cell-free technique could enable on-demand vaccine production
April 22, 2021 -- A new cell-free synthetic biology technique that increases the volume of membrane components in the manufacture of conjugate vaccines can significantly improve the efficiency of vaccine production, according to a new method published in Nature Communications on April 22. The technology could enable on-site production of vaccines and therapies, enabling them to be more efficiently distributed in areas where they are most needed. Read More
Scientists map gene expression without microscopes
April 21, 2021 -- A new framework called Tomographer, which uses sequencing data from tissues cut into thin strips in a way that allows them to be reconstructed, has been developed to spatially resolve gene expression data without the need for a microscope. The work was published in Nature Biotechnology on April 19. Read More
New algorithm helps integrate single-cell data from around the globe
April 20, 2021 -- A new algorithm enables researchers from around the globe to integrate multiple single-cell datasets from a variety of omics platforms in a quick and efficient process that can be done on standard computers. The technology, described in an April 19 Nature Biotechnology article, will help speed collaborative cell cataloging projects, such as the Human Body Map and Human Cell Atlas. Read More
Variant-resistant COVID-19 vaccines could be effective, cheap to make
April 19, 2021 -- Researchers have collaborated to create a new COVID-19 vaccine platform containing antigens against the fusion protein of the SARS-CoV-2 virus that could be effective against variants of the virus. The research was published online on April 15 in the Proceedings of the National Academy of Sciences. Read More
How can women overcome challenges to success in life sciences?
April 16, 2021 -- The gender gap is still alive and well in the life sciences, despite the great progress that has been made in recent years. But women can overcome challenges and find success in the life sciences industry, according to Olga Kubassova, PhD, chief executive officer of Image Analysis Group. Read More
AACR 2021: A case study of T-cell modulation for cancer immunotherapies
April 15, 2021 -- During a plenary session at the American Association for Cancer Research (AACR) 2021 virtual meeting held April 9-14, speakers described impressive work that researchers have done to modify and target T cells as a means of treating cancers. Read More
AACR 2021: How machine learning and artificial intelligence are transforming cancer research
April 14, 2021 -- The use of digital tools has been incorporated into many areas of cancer research. However, experts agree that machine learning and artificial intelligence are poised to transform drug discovery efforts even further in the near future. Several scientists discussed case studies of how machine learning can be used in cancer biology and drug discovery efforts during the virtual American Association for Cancer Research (AACR) 2021 meeting. Read More
AACR 2021: Single-cell technologies bring new insights to tumor cells
April 13, 2021 -- Single-cell technologies have become important tools for cancer researchers and provide scientists with the ability to make measurements of individual cells to unveil heterogenicity among tissues. Recent developments in single-cell research have been a focus of the virtual American Association for Cancer Research (AACR) 2021 meeting held online April 9-14. Read More
A CRISPR on-off switch for genes controls expression without altering DNA
April 12, 2021 -- A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression. Read More
BioTools Innovator seeks to boost startups developing life science tools
April 9, 2021 -- BioTools Innovator is calling for applications to its inaugural competition to advance innovation by accelerating the growth of startups developing life science tools. Kathryn Zavala, PhD, managing director, recently discussed the program with ScienceBoard.net. Read More
NIH details progress of SCGE consortium
April 8, 2021 -- The U.S. National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) consortium has provided a detailed update, published in Nature on April 8, of projects to develop safer and more effective genome editing methods in somatic cells. Read More
Will preprints have a lasting effect on publishing beyond COVID-19?
April 7, 2021 -- During the COVID-19 pandemic, 25% of all COVID-19-related scientific manuscripts were shared on preprint servers, a steep increase from previous usage and relative to traditional peer-review journals. An international team of researchers explored the critical role of preprint servers in disseminating epidemic-related information in an article published in PLOS Biology on April 2. Read More
Improved RNA sequencing method reveals new insights into small RNAs
April 6, 2021 -- Researchers have developed a new RNA sequencing method that can help discover many types of previously undetectable small RNAs. Details of the method, called panoramic RNA display by overcoming RNA modification aborted sequencing (PANDORA-seq), were published in Nature Cell Biology on April 5. Read More
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