Proteomics
New software finds relationships between RNA modifications, cancers
A new computational tool called ModTect could identify RNA modifications using preexisting sequencing data gathered from clinical cohort studies. The tool may bring scientists closer to understanding the relationships between RNA modifications and the development of cancer and other diseases, according to a recent study in Science Advances. Read More
Thermo Fisher announces new spectrometers, facility, more
Thermo Fisher Scientific announced that it is building a manufacturing facility in Tennessee. In addition, it has released a line of spectrometers and a liquid chromatography system. Read More
Researchers figure out how the immune system sparks cell death
Immunologists have discovered how the innate immune system launches a multifaceted attack against invaders through the use of multiple immune sensors. The work was published in Nature on September 1. Read More
Sciex launches BioPhase 8800 for high-throughput capillary electrophoresis
Sciex has launched BioPhase 8800, a new capillary electrophoresis system for enhanced biologic characterization in the development of biopharmaceutical therapies. The new instrument is a multicapillary system for capillary electrophoresis sodium dodecyl sulfate that processes eight samples simultaneously. Read More
'Dimmable' switch for gene therapy shows potential for rare diseases
A new alternative splicing system called Xon can modulate levels of protein expression in gene therapy, much like a dimmer switch. The invention addresses a major shortcoming of most gene therapies, which is the ability to regulate gene expression levels in diseases like spinal muscular atrophy. Read More
Vizgen begins shipping Merscope instruments for single-cell genomics
Vizgen has shipped its first commercial Merscope instruments to research institutions as part of a limited summer release program. Merscope enables high-plex, single-cell spatial genomics and large-scale spatial profiling of individual transcripts within cells. Read More
ARES deep-learning system improves 3D RNA structure prediction
A new deep-learning system called Atomic Rotationally Equivariant Scorer (ARES) significantly improves the prediction of RNA structures over previous artificial intelligence models. The advance, described by Stanford University researchers in a paper in Science on August 26, may help scientists uncover the biological functions of RNA and pave the way to the discovery of novel RNA-targeted drugs. Read More
'Minibrains' grown from stem cells replicate brain's electrical activity
Researchers have grown 3D human brain tissue from stem cells that replicates the patterns of electrical activity found in the brains of patients with Rett syndrome. These "minibrain organoids" can be used to investigate the underlying causes of neurological disease and screen and test potential drug candidates, according to research published on August 23 in Nature Neuroscience. Read More
Cell and gene therapy firms see over $13.6B so far in 2021
Rapid financing activity in the cell and gene therapy industry has exceeded $13 billion in 2021. Over half of this funding is from venture capital and private investments, with over 100 funding deals of this type. Read More
COVID multiomics dataset, portal go online for public use
A new multidimensional dataset for COVID-19 multiomics research has been released to the public, along with a free online research portal for analyzing the data. The COVIDome Explorer and dataset, described recently in Cell Reports, give researchers a way to share data and collaborate in real-time for the clinical management of COVID-19. Read More
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
European Molecular Biology Laboratory (EMBL) Cancer Genomics Conference
November 22-24
Heidelberg Germany
Science Briefs
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
European Molecular Biology Laboratory (EMBL) Cancer Genomics Conference
November 22-24
Heidelberg Germany
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