The Science Advisory Board

RNA sequencing Western blot Crystallography Immunoassays

Genetic engineering shows how 'foreign' DNA impacts evolution
A new study has demonstrated that "foreign" DNA -- DNA transferred horizontally into a species from a source other than a parent -- can become functional over time and can impact an organism's evolution and fitness, according to a paper published August 10 in Nature Ecology and Evolution. Discuss

Microbes shape antibodies prior to infection
Genetic analysis of antibodies reveals how microbes in the intestines impact overall B-cell populations and humoral responses to pathogens. The research was published in Nature on August 5. Discuss

Antiviral molecules targeting SARS-CoV-2 main protease are potent inhibitors
New compounds targeting the SARS-CoV-2 main protease could be potent inhibitors of the coronavirus. Researchers tested various engineered molecules for antiviral activity in an article published in Science Translational Medicine on August 3. Discuss

Study analyzes how SARS-CoV-2 undermines immune defenses
A new research study used whole-genome sequencing to analyze the genetic profile of patients with the SARS-CoV-2 virus to gain more insight into how it turns the body's own immune system against itself. The findings could help researchers develop drugs to target the virus, according to an August 3 report in Nature Medicine. Discuss

Researchers further define nonstructural protein targets of SARS-CoV-2
The crystal structure of nonstructural protein 16 of SARS-CoV-2, which plays a role in viral RNA capping to mimic host messenger RNA, reveals specific rational design targets that could be used to develop effective therapies against SARS-CoV-2 and other coronaviruses. The research was published in Nature Communications on July 24. Discuss

Inhibiting SARS-CoV-2 papain-like protease may stop viral spread
Another nonstructural protein, papain-like protease, has been identified as a SARS-CoV-2 therapeutic target with the potential to block viral replication, according to an article published in Nature on July 29. Discuss

SARS-CoV-2 disguises its own genetic material to facilitate infection
The SARS-CoV-2 virus is able to camouflage itself to promote viral replication, as revealed by structural details of proteins on the surface of the virus. Researchers discovered an enzyme that they believe could be an important target for antiviral drug development, according to a July 14 Nature Communications report. Discuss

Life science instrumentation market adapts to COVID-19
To reflect the new realities of the analytical instrumentation market during the COVID-19 pandemic and in the subsequent pandemic-driven recession, Strategic Directions International, a sister company of The Science Advisory Board, has released its revised edition of the Global Assessment Report. Discuss

Unveiling bat secrets of immunity could offer clues to treating COVID-19
Bats' longevity and capacity to tolerate viruses may stem from their ability to control inflammation, according to a review article published in Cell Metabolism on July 7. The unique mechanisms that bats employ to achieve this may hold clues to developing new treatments for human diseases. Discuss

How has SARS-CoV-2 evolved from bat coronavirus?
Structural comparison between a bat coronavirus and SARS-CoV-2 reveals specific characteristics that make the new virus more pathogenic, according to a new article published in Nature Structural and Molecular Biology on July 9. Discuss

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Science Briefs

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