Protein crystallography links rigid antibody hinges to increased anticancer activity Researchers at the University of Southampton have gained new insight into the key properties of an antibody needed to fight off cancer using protein crystallography, revealing that the flexibility of the hinge between the arms of IgG2 antibodies affects the anticancer effects triggered by the molecules.Read More
EMBL partners with DeepMind to predict 3D structure of human proteins Google Health's DeepMind announced a partnership with the European Molecular Biology Laboratory (EMBL) to offer the scientific community open access to the most comprehensive database developed to date of predicted 3D protein structures.Read More
Future of small-molecule drugs lies in oral formulations The way forward for small-molecule drug manufacturers is through orally administered products, according to Spiro Rombotis, president and CEO of Cyclacel, who recently spoke with ScienceBoard.net.Read More
How one mammalian DNA polymerase challenges the central dogma of biology New research demonstrates how an unusual mammalian DNA polymerase can facilitate the conversion of RNA into DNA -- the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins.Read More
Scientists show how SARS-CoV-2 wreaks havoc in lungs Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 envelope protein in a study published June 8 in Nature Communications. The model shows how the virus interacts with lung proteins, helping to explain how SARS-CoV-2 causes extensive lung damage.Read More