Aiming targeted protein degradation at kinase unlocks potential way to treat Alzheimer’s
A targeted protein degrader could break apart a kinase implicated in Alzheimer’s disease to improve the cognitive abilities of patients with the neurodegenerative condition, according to a study published March 1 in ACS Central Science. Read More
Toxic protein linked to both muscular dystrophy and arhinia
National Institutes of Health (NIH) researchers and collaborators have found that DUX4, a toxic protein made by the body, may be responsible for two very different rare genetic disorders. The study, published on Friday in Science Advances, may eventually lead to therapies that can help people with a type of muscular dystrophy, as well as those with a facial malformation called congenital arhinia. Read More
MIT researchers record cellular memories through protein chains
Using engineered proteins, MIT researchers have designed a system in which they can record “memories” of sequences of cellular events, such as when certain genes are activated, or how cells respond to a drug, as cells turn on series of genes and pathways in performing functions. Read More
CRISPR edited rat embryos reveal cause of rare pediatric neurodegenerative disease
Using CRISPR gene editing technology on rat embryos, University of Wisconsin-Madison researchers have revealed the mutation that is responsible for progressive gait abnormalities and other symptoms in human infants and young children with a rare neurodegenerative disease. Read More
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