Proteomics
Single-cell atlas of human teeth exposes root of stem cell behavior
The first comprehensive single-cell atlas of the human tooth reveals how different dental tissues control the activity of stem cells. Published recently in iScience, the study used advanced single-cell sequencing technology to show that changes in the cellular environment may explain differences in the behavior of stem cells. Read More
New tool sheds light on transient protein interactions in cells
Researchers have developed a novel chemical tool for elucidating protein interaction networks within cells. The technique, details of which were published in Molecular Cell on April 23, allows for the visualization of protein-protein interactions. Read More
Scientists map gene expression without microscopes
A new framework called Tomographer, which uses sequencing data from tissues cut into thin strips in a way that allows them to be reconstructed, has been developed to spatially resolve gene expression data without the need for a microscope. The work was published in Nature Biotechnology on April 19. Read More
New algorithm helps integrate single-cell data from around the globe
A new algorithm enables researchers from around the globe to integrate multiple single-cell datasets from a variety of omics platforms in a quick and efficient process that can be done on standard computers. The technology, described in an April 19 Nature Biotechnology article, will help speed collaborative cell cataloging projects, such as the Human Body Map and Human Cell Atlas. Read More
AACR 2021: A case study of T-cell modulation for cancer immunotherapies
During a plenary session at the American Association for Cancer Research (AACR) 2021 virtual meeting held April 9-14, speakers described impressive work that researchers have done to modify and target T cells as a means of treating cancers. Read More
AACR 2021: Single-cell technologies bring new insights to tumor cells
Single-cell technologies have become important tools for cancer researchers and provide scientists with the ability to make measurements of individual cells to unveil heterogenicity among tissues. Recent developments in single-cell research have been a focus of the virtual American Association for Cancer Research (AACR) 2021 meeting held online April 9-14. Read More
A CRISPR on-off switch for genes controls expression without altering DNA
A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression. Read More
Improved RNA sequencing method reveals new insights into small RNAs
Researchers have developed a new RNA sequencing method that can help discover many types of previously undetectable small RNAs. Details of the method, called panoramic RNA display by overcoming RNA modification aborted sequencing (PANDORA-seq), were published in Nature Cell Biology on April 5. Read More
Cancer anti-inflammatory drug has potential to treat severe COVID-19
A new study provides evidence that an inexpensive clinical-grade inhibitor that's already approved to treat cancer, called topotecan, can be used to treat severe COVID-19, even in the late stages of the disease. The findings were published in Cell on March 30. Read More
Prime editing creates desired gene mutations without collateral damage
A new gene editing tool called prime editing was demonstrated to efficiently create cell-specific knockout mice compared to traditional gene editing techniques. While both platforms successfully created mutations, prime editing did so without measurable on-target indels or off-targeting events, according to a study published in Genome Biology on March 16. Read More
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