Proteomics
New platform identifies best viral vectors for gene therapy
Researchers have developed a novel computational platform that identifies the best viral vector to deliver a gene therapy to its target. The technology, described October 19 in eLife, promises to speed development of adeno-associated virus-mediated gene therapies against vision loss and other disorders. Read More
New algorithm enables comparisons of tumors across patients
Researchers have developed an algorithm that can take either single-cell mass cytometry data or RNA sequencing data, align it, and extract a common denominator for comparing cancer data among patients. The algorithm, called tuMap, was detailed in a study published on October 7 in Cell Systems. Read More
New 4D visualization shows epigenetic processes unfold over time
Scientists have developed a new visualization method to construct 4D models of X chromosome inactivation, lending insight into gene expression and opening new pathways to drug treatments for gene-based disorders and diseases. The findings are being published on October 8 in the Proceedings of the National Academy of Sciences of the United States of America. Read More
Nanoscale sequencer detects 2 cancer-linked RNA base modifications simultaneously
Using a new nanoscale sequencer, a research group has sequenced a microRNA that is a marker for refractory gastrointestinal cancer. The novel method can detect two types of chemical base modifications simultaneously, according to a study published on September 29 in Scientific Reports. Read More
New software finds relationships between RNA modifications, cancers
A new computational tool called ModTect could identify RNA modifications using preexisting sequencing data gathered from clinical cohort studies. The tool may bring scientists closer to understanding the relationships between RNA modifications and the development of cancer and other diseases, according to a recent study in Science Advances. Read More
'Minibrains' grown from stem cells replicate brain's electrical activity
Researchers have grown 3D human brain tissue from stem cells that replicates the patterns of electrical activity found in the brains of patients with Rett syndrome. These "minibrain organoids" can be used to investigate the underlying causes of neurological disease and screen and test potential drug candidates, according to research published on August 23 in Nature Neuroscience. Read More
Cell and gene therapy firms see over $13.6B so far in 2021
Rapid financing activity in the cell and gene therapy industry has exceeded $13 billion in 2021. Over half of this funding is from venture capital and private investments, with over 100 funding deals of this type. Read More
COVID multiomics dataset, portal go online for public use
A new multidimensional dataset for COVID-19 multiomics research has been released to the public, along with a free online research portal for analyzing the data. The COVIDome Explorer and dataset, described recently in Cell Reports, give researchers a way to share data and collaborate in real-time for the clinical management of COVID-19. Read More
Long-read sequencing of circRNA finds autism-linked microexons
Scientists have developed a new laboratory protocol and bioinformatic pipeline using a long-read sequencing platform from Oxford Nanopore Technologies for exploring the composition of circular RNA (circRNA). The technique, published on August 10 in Nature Communications, showed that a group of microexons that had been previously linked to autism are preferentially found in circRNA. Read More
Researchers identify chronic stress gene target in brain
By studying how genes affect receptors in the brain under stress, researchers have discovered new molecular mechanisms behind the function of corticosterone, the stress hormone. The research was published in Nature Communications on August 6. Read More
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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