RNA molecules identified as potential ‘common driver’ of cancer progression Moffitt Cancer Center researchers have challenged the widely held view that protein structure and function are the key drivers of cancer development. Their study found competitive endogenous RNA drive melanoma growth and metastasis by blocking the antitumor activity of other molecules.Read More
Biotech innovator recounts decades-long journey to create drug discovery technology Dr. Stan Crooke, PhD, founder, chairman, and chief executive officer of RNA therapy company Ionis Pharmaceuticals, pioneered development of the antisense technology platform and created one of the largest, most advanced pipelines in the biotech industry. Crooke shared his story in an interview with ScienceBoard.net.Read More
Cellular map of tissues created by combining sequencing techniques Researchers have described an approach to combine single-cell sequencing experiments with spatial transcriptomics to create maps of tissues according to cell type, according to new research published on March 21 in the journal Nature Biotechnology.Read More
Endosomal pH drives stemness in glioblastoma A group of researchers has shown that endosomal pH drives stemness in glioblastoma. The group discovered that endosomal Na+/H+ exchanger isoform 9 is a novel driver of stem cell-like characteristics -- or stemness -- in glioblastoma by stabilizing multiple receptor tyrosine kinases, according to a recent paper published in PNAS Nexus.Read More