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MIT researchers record cellular memories through protein chains
Using engineered proteins, MIT researchers have designed a system in which they can record “memories” of sequences of cellular events, such as when certain genes are activated, or how cells respond to a drug, as cells turn on series of genes and pathways in performing functions.
Wyss Institute launches RNA therapeutics startup EnPlusOne Biosciences
Wyss Institute at Harvard University has partnered with Northpond Labs to launch EnPlusOne Biosciences. The startup aims to bring versatile, scalable RNA synthesis technology to market, with the goal of unlocking the development of new RNA drugs, vaccines, and gene-editing therapies.
Proteomic signature improves detection of hard-to-identify form of prediabetes
Testing for a three-protein signature in the blood could improve the detection of a form of prediabetes, according to research published November 10 in the journal
Benchtop single-molecule protein sequencing unlocks new way to study proteome
Life sciences company Quantum-Si has developed a benchtop instrument that performs single-molecule protein sequencing, setting the stage for a new approach to studying the proteome.
CRISPR edited rat embryos reveal cause of rare pediatric neurodegenerative disease
Using CRISPR gene editing technology on rat embryos, University of Wisconsin-Madison researchers have revealed the mutation that is responsible for progressive gait abnormalities and other symptoms in human infants and young children with a rare neurodegenerative disease.
Boosting TERRA levels damages DNA of hard-to-kill cancer cells: study
Increasing levels of telomeric repeat-containing RNA (TERRA) damages the DNA of cancers with a particular form of replicative immortality and leads to cell death, according to Portuguese researchers who show that “anti-aging clocks” can be used to kill cancer cells.
Machine learning may accelerate solutions to address protein design challenges
Machine learning can be used to create protein molecules much more accurately and quickly than previously possible, with the potential for developing new treatments and vaccines, according to biologists at the University of Washington School of Medicine.
Genomics profiling reveals how Zika infects immune cells, suggests antiviral target
A genomics profiling method has revealed how the Zika virus infects human dendritic cells, pointing to a potential target for therapeutic suppression of the pathogen.
MIT team finds limitations of AlphaFold’s AI protein structures in drug discovery
Advances in the modeling of protein-ligand interactions are needed to realize the potential of the artificial intelligence (AI) AlphaFold database of protein structure predictions in drug discovery, according to a new paper from researchers at the Massachusetts Institute of Technology (MIT).
Hormone therapy improves cognitive function in Down syndrome in small pilot study
Subcutaneous doses of gonadotropin-releasing hormone, a master molecule that controls reproduction, may improve cognitive function in men with Down syndrome, according to results of a small pilot study built on research in mice.
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Protillion Biosciences raises $18M in financing to support therapeutic biomarker discovery
New method detects 'buddy' proteins within cells
Mitochondria seen as common thread in autism spectrum disorder
Researchers discover way to increase synthetic mRNA's protein production
Scientists use new chemoproteomic method for global profiling of arginine dimethylation
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