Cell Biology
Researchers discuss progress toward personalized cancer vaccines
Highly targeted and adaptable platforms allow researchers to develop cancer vaccines for a multitude of different cancer types and even create personalized vaccines for individual cancer patients. Researchers from BioNTech and the Wistar Institute shared exciting developments in cancer vaccines in a methods workshop during the American Association for Cancer Research 2020 virtual annual meeting II.  Discuss
Childhood vaccines may help protect against COVID-19 mortality
Could live vaccines for viruses such as measles, mumps, and rubella (MMR) also provide protection against COVID-19? That intriguing prospect is the subject of a recently published commentary in mBio.  Discuss
Some viruses may steal host genes to form beneficial hybrid proteins
Certain types of RNA viruses may be capable of using host RNA to expand their own genetic repertoire, according to a new study published in Cell on June 18. This mechanism may enable viruses to overcome the limitations of small genomes and more effectively infect host cells.  Discuss
Cloaked nanoparticles may be a powerful therapy against coronaviruses
Nanoparticles cloaked with human cell membranes can attract and neutralize SARS-CoV-2, according to a new publication in Nano Letters on June 17. The process of binding to the virus hijacks its ability to replicate, making it a viable medical countermeasure against the virus.  Discuss
Optofluidics aids cell line development for antibody-based therapies
Implementation of optofluidics in cell line development can help advance multiple lead candidate molecules with increased screening capacity. A researcher from GlaxoSmithKline discussed how her team uses an optofluidic system in a June 15 presentation at the BioProcess International Spring Digital Week's 2020 virtual meeting.  Discuss
Are interferons helpful or harmful during SARS-CoV-2 infection?
The host immune system produces a variety of regulatory molecules, including interferons, during a response to viral infection. Although previously considered beneficial, these proteins may actually cause life-threatening inflammation, according to an article published in Science on June 11.  Discuss
NIH researchers investigate virulence of SARS-CoV-2 virus
What makes the SARS-CoV-2 virus so virulent? Researchers from the U.S. National Institutes of Health (NIH) analyzed the genomics of the virus -- and compared it to other coronaviruses -- in a June 10 article in the Proceedings of the National Academy of Sciences.  Discuss
How will summer weather shape the spread of COVID-19?
New research shows that while higher temperatures and humidity can slow the spread of COVID-19, longer hours of sunlight are associated with a higher incidence of the disease. Human behavior may be at the root of this quandary, according to a June 8 Geographical Analysis publication.  Discuss
Pioneering technology stabilizes vaccines at all temperatures
Scientists have identified a new method called ensilication to prevent warmed-up vaccines from degrading. By coating proteins in a silica shell, the structures remain intact and effective. A new study published in Scientific Reports on June 8 expands on previous knowledge about the technique and provides crucial in situ and in vivo evidence for real-world applications.  Discuss
Preclinical innovations can speed COVID-19 drug development
Preclinical testing for drug candidates has remained largely unchanged, despite numerous innovations in cell culture techniques. Researchers discussed how these innovations could help speed drug discovery efforts for the COVID-19 pandemic in an article published in Theranostics.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
General Discussion
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