Cell Biology
Solid tumors targeted with investment into innovative therapies
Solid tumors are particularly difficult to treat due to their ability to evade detection by the immune system. And even if these tumors are detected, immune cells often struggle to efficiently attack them at their core, leading to continued growth. Despite these roadblocks, companies such as 2seventy bio, Bristol Myers Squibb, and Transgene are rising to the challenge through collaborations and investments into technology to treat solid tumors. Read More
Critical step identified in immune system response could lead to new treatments
New research has identified a crucial protein that controls the immune system's release of a key factor in fighting infections. The study, published in the journal Nature Communications on January 10, found that the MNDA protein is necessary for white blood cells to produce a type of interferon. This discovery could lead to new drugs to help fight infections or treat autoimmune conditions. Read More
Gamma delta T cells may hold key to malaria immunity
Scientists have shown how a poorly understood group of immune cells -- gamma delta T cells -- are directly involved in immunity to malaria, according to research published December 1 in Science Translational Medicine. The results promise to spur the future development of next-generation malaria vaccines. Read More
Myxoma virus enters as an exciting preclinical cancer immunotherapy platform
A preclinical oncolytic viral vector platform under development was of interest at the recent Society for Immunotherapy of Cancer's 2021 annual meeting. OncoMyx Therapeutics' Chief Scientific Officer Leslie Sharp, PhD, spoke with ScienceBoard at the meeting. Read More
The continued challenges of flavivirus serology
Flaviviruses are a genus of positive-sense RNA viruses, largely transmitted by mosquito and tick vectors that cause infections, including yellow fever, dengue, the Zika virus, West Nile virus, Japanese encephalitis, and tick-borne encephalitis. In fighting the emergence of flaviviruses, a well-established gap in our arsenal is the availability of accurate diagnostic data. Read More
Nanopore sensor quickly detects infectious viruses
Scientists have designed a nanopore-based sensor that can detect the presence and infectiousness of a virus in a sample within minutes, according to a new study published in Science Advances on September 22. The new method successfully detected SARS-CoV-2, positioning it as a speedier, less fussy alternative to other tests. Read More
New gene therapy platform shows potential against certain muscle diseases
Scientists have engineered a new family of adeno-associated viruses (AAVs) to deliver therapeutic genes to muscle tissue at 100 to 250 times lower doses than previous AAV vectors, potentially reducing the risk of liver damage and other serious side effects, according to a new study published in Cell on September 9. Read More
Researchers figure out how the immune system sparks cell death
Immunologists have discovered how the innate immune system launches a multifaceted attack against invaders through the use of multiple immune sensors. The work was published in Nature on September 1. Read More
Mirus Bio introduces viral vector manufacturing reagents
Mirus Bio announced an expansion of its TransIT VirusGen platform that is compliant with good manufacturing practices viral vector manufacturing to support cell and gene therapy development, process activities, and commercial production. Read More
Scientists visualize viruses in motion using advanced electron microscopy
Advanced electron microscopy has enabled researchers to visualize how human viruses move in high resolution in a near-native environment. The visualization technique, published in Advanced Materials on July 24, could lead to an improved understanding of the molecular mechanisms of vaccines and therapeutics. Read More
Conferences
International Society for Cell and Gene Therapy Annual Meeting
May 4 - June 7
San Francisco, California United States
Interphex 2022 Conference
May 24-26
New York, New York United States
American Society for Mass Spectrometry Annual Conference
June 5-9
Minneapolis, Minnesota United States
American Society for Microbiology Microbe Meeting
June 9-13
District of Columbia United States
HPLC 2022
June 18-23
San Diego, California United States
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