Cell Biology
Oncolytic viruses move closer to becoming effective cancer therapies
Scientists are identifying key factors that aid in the effectiveness of oncolytic viruses during the treatment of cancers, which could lead to better immunotherapies and inform clinicians which patients might benefit from the treatment. Findings from a June 22 Nature Communications article point to the clinical relevance and underlying mechanisms of a novel anticancer treatment. Read More
New in vitro models offer effective way to study respiratory viruses
A new accessible and scalable protocol for manufacturing in vitro lung cell models could have applications in the development of new therapies for respiratory viral infections and drug toxicology studies on human lungs. Details about the protocol were published in Stem Cells on June 21. Read More
New AI model could predict viral jumps from animals to humans
A new artificial intelligence (AI)-based computational model called SweetNet aimed at characterizing complex carbohydrates could help predict which viruses are likely to spread from animals to humans. The details of the research were published in Cell Reports on June 15. Read More
How one mammalian DNA polymerase challenges the central dogma of biology
New research demonstrates how an unusual mammalian DNA polymerase can facilitate the conversion of RNA into DNA -- the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins. Read More
Scientists show how SARS-CoV-2 wreaks havoc in lungs
Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 envelope protein in a study published June 8 in Nature Communications. The model shows how the virus interacts with lung proteins, helping to explain how SARS-CoV-2 causes extensive lung damage. Read More
Leveraging past flu pandemics helps build universal flu vaccine
Targeting regions of the influenza virus that do not often change may be an effective strategy for developing next-generation universal flu vaccines, according to new research published in Science Translational Medicine on June 2. Researchers interrogated immune responses from the 2009 H1N1 influenza pandemic to determine which targets to include in new vaccines. Read More
FDA updates requirements for COVID-19 vaccine EUAs
The U.S. Food and Drug Administration (FDA) issued a new guidance document on May 25 that updates previously issued guidance and sets expectations for future COVID-19 vaccine emergency use authorizations (EUAs) during the pandemic. Read More
New research uncovers how SARS-CoV-2 hijacks RNA host proteins
A new study has uncovered the interactions that SARS-CoV-2 RNA establishes with the host cell proteins, many of which are fundamental for infection. The results, published in Molecular Cell on May 24, pave the way for the development of new therapeutic strategies for COVID-19 with broad-range antiviral potential. Read More
CRISPR gene editing adapted for white blood cells
An adapted version of the CRISPR-Cas9 gene editing technique opens up the ability to manipulate human monocytes -- white blood cells that play vital roles in the immune system. The new study, published in Cell Reports on May 11, shows that the cells function normally following gene editing, allowing biologists to better understand how the cells interact with diseases like HIV. Read More
Nobel Prize winner Doudna shares perspectives on future of CRISPR gene editing
Small science can translate into big discoveries, according to Nobel Prize laureate Jennifer Doudna, PhD. She discussed how her curiosity in understanding CRISPR led to the gene editing revolution in a talk at the 2021 American Society of Gene & Cell Therapy virtual meeting. Read More
Conferences
CPhI North America
August 10-12
Philadelphia, Pennsylvania United States
Bioprocessing Summit
August 16-19
Boston, Massachusetts United States
6th Annual CAR-TCR Summit
August 30 - September 2
Online
European Congress of Immunology (ECI) 2021
September 1-4
Belgrade Serbia
Medical Affairs Strategic Summit (MASS)
September 13-15
New Brunswick, New Jersey United States
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