Cell Biology
Microbes shape antibodies prior to infection
Genetic analysis of antibodies reveals how microbes in the intestines impact overall B-cell populations and humoral responses to pathogens. The research was published in Nature on August 5.  Discuss
Antiviral molecules targeting SARS-CoV-2 main protease are potent inhibitors
New compounds targeting the SARS-CoV-2 main protease could be potent inhibitors of the coronavirus. Researchers tested various engineered molecules for antiviral activity in an article published in Science Translational Medicine on August 3.  Discuss
Inhibiting SARS-CoV-2 papain-like protease may stop viral spread
Another nonstructural protein, papain-like protease, has been identified as a SARS-CoV-2 therapeutic target with the potential to block viral replication, according to an article published in Nature on July 29.  Discuss
Pall debuts solution for biotech research
Pall, one of the largest suppliers of laboratory filtration and clarification products, recently launched two new filtration and clarification plates designed to improve cell and protein purification.  Discuss
Heated nickel foam HVAC filters could protect against SARS-CoV-2
New "catch and kill" air filters can instantly and efficiently kill SARS-CoV-2, the virus responsible for COVID-19. The details of the nickel foam-based prototype were published in Materials Today Physics on July 7.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
Optofluidics aids cell line development for antibody-based therapies
Implementation of optofluidics in cell line development can help advance multiple lead candidate molecules with increased screening capacity. A researcher from GlaxoSmithKline discussed how her team uses an optofluidic system in a June 15 presentation at the BioProcess International Spring Digital Week's 2020 virtual meeting.  Discuss
Preclinical innovations can speed COVID-19 drug development
Preclinical testing for drug candidates has remained largely unchanged, despite numerous innovations in cell culture techniques. Researchers discussed how these innovations could help speed drug discovery efforts for the COVID-19 pandemic in an article published in Theranostics.  Discuss
Study reveals genomic similarity between SARS-CoV and SARS-CoV-2
A new technique has shown that conserved genetic sequences between SARS-CoV and SARS-CoV-2 may be important for their stability within host cells and ability to infect and replicate efficiently. The methodology was published in Biochemical and Biophysical Research Communications.  Discuss
Need for efficiency, COVID-19 vaccine spurs biomanufacturing in 2020
With the urgent need for COVID-19 therapies and vaccines, funding agencies have prioritized biomanufacturing; companies in turn are preparing to ramp up a variety of biologics. The strong demand for bioprocessed medicines in 2020 will continue to drive growth of the industry.  Discuss
Conferences
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
BioProcess International
September 21-24
Eastern Standard Time Zone (EST), Massachusetts United States
General Discussion
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