The Science Advisory Board

Cell culture Cell-based analysis Virology Bacteriology Microbiome

Machine learning helps identify antimicrobial-resistant bacteria
A new graphical user interface-driven, machine learning-based approach has successfully identified antimicrobial resistance genes for gram-positive and -negative bacteria. This work, presented in Scientific Reports on July 3, may make it easier to identify deadly antimicrobial-resistant bacteria. Discuss

Major class of probiotics gets new taxonomy
A new paper published in the International Journal of Systematic and Evolutionary Microbiology proposes major changes to the classification and naming of Lactobacillus probiotics based on new information gained by modern DNA analysis tools. Discuss

Directed evolution shows promise in reducing drug discovery times
A research collaboration between scientists at the University of Leeds and AstraZeneca resulted in the development of a technique that can significantly reduce the discovery time for possible new antibody-based therapies. The approach, published in Nature Communications on April 14, shows how protein fragments can be screened for susceptibility to aggregation in early drug discovery. Discuss

Horseshoe crab 'farming' preserves species, makes blood test possible
Researchers have developed a new aquaculture-based method to harvest immune cells from horseshoe crabs that preserves the crustaceans while also creating the potential for new clinical applications, like testing blood for sepsis, according to a study published in Frontiers in Marine Science on April 1. Discuss

Gene amplification can be responsible for functional innovation in bacteria
Researchers have gained a greater understanding of how gene amplifications rapidly tune levels of gene expression when gene regulation is required but when no other molecular regulatory mechanisms are in place. This research was published in Nature Ecology & Evolution on March 9. Discuss

Bacteria survive by possessing multiple genes to uptake the same amino acid
Researchers have long known that the uptake systems in clonal cells can differ based on their environments. Scientists reported their observations of this amino acid uptake pathway in bacteria for the first time in a new study published March 5 in Nature Communications. Discuss

Artificial intelligence helps researchers find new antibiotics
To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find new potential antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing. Discuss

Genetically engineered probiotics successfully deliver immunotherapies
A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine. Discuss

Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes. Discuss

T cells work as a team to fight infection
Immune cells may be better at sensing each other than previously thought, according to a new study published in Immunity on February 11. Researchers from Germany, the Netherlands, and the U.K. revealed a mechanism T cells use to work as a team and mutually determine how to fight infections. Discuss

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July 13-17
Central European Time Zone (CET) Netherlands

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2020 ACCP Annual Meeting
September 20-22
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