Cell Biology
Endosomal pH drives stemness in glioblastoma
A group of researchers has shown that endosomal pH drives stemness in glioblastoma. The group discovered that endosomal Na+/H+ exchanger isoform 9 is a novel driver of stem cell-like characteristics -- or stemness -- in glioblastoma by stabilizing multiple receptor tyrosine kinases, according to a recent paper published in PNAS Nexus. Read More
Flexibility is key for automated flow cytometry workflows
A tutorial titled "Handling Large Data Sets Generated by Flow Cytometry in an Automated Environment" presented by Bio-Rad at the Society for Laboratory Automation and Screening 2022 International Conference and Expo demonstrated the flexibility and power of the company's flow cytometry workflow, from reagents and instrumentation to automation and data analysis. Read More
How one company is helping make complex medicines safer
Often, the most dangerous things in life are things that the human eye cannot see. This is true even for life-saving medicines. One company was founded to help the industry find these hidden particles and solve a key challenge in the development of complex drug products. Halo Labs’ CEO Rick Gordon spoke with ScienceBoard about how its low volume approach is providing a critical service for the drug development industry. Read More
Machine vision advances single-cell sequencing for small samples
The ability to sequence RNA in single cells has given scientists an unprecedented level of resolution in studying rare cell types. However, current approaches are designed to deal with a large number of cells, making it difficult to work with small samples. New research, published in Nature Methods on February 14, has described a technique using machine vision to detect cells and make single-cell RNA sequencing more efficient at a smaller scale. Read More
Roswell Biotechnologies demonstrates scalable molecular electronics chip
Roswell Biotechnologies and leading academic scientists have developed the first molecular electronics chip, realizing a 50-year-old goal of integrating single molecules into circuits to achieve the ultimate scaling limits of Moore's Law. Read More
Pancreatic stellate cells promote cancer cell proliferation, tumor growth
Using optical imaging to study metabolic processes as they relate to tumor growth, researchers hope to better understand the tumor microenvironment and potential interventions. New research published on January 21 in Science Advances showed that pancreas cells co-cultured with pancreatic cancer cells in 3D organoids resulted in increased pancreatic cancer cell growth. Read More
BD innovation highlights new flow cytometry tech
A new study conducted by Becton Dickinson (BD) in collaboration with the European Molecular Biology Laboratory, which was published as the cover story of Science on January 20, profiles a BD innovation in flow cytometry that adds fluorescence imaging and image-based decisioning to sort individual cells at an exceptionally high speed. Read More
Scientists develop novel tools to visualize DNA repair
Researchers can now visualize DNA repair in unprecedented detail using a new high-throughput microscopy technique in combination with machine learning. The methodology, published in Cell Reports on December 28, has led to the identification of new proteins involved in DNA repair. Read More
Cool imaging measures cells in motion
A new method, which involves cooling living cells at extremely fast speeds, leads to unprecedented preservation of cellular biomolecules in their natural arrangement at the moment of arrest. Details of the technique were published in Science Advances on December 10. Read More
Gamma delta T cells may hold key to malaria immunity
Scientists have shown how a poorly understood group of immune cells -- gamma delta T cells -- are directly involved in immunity to malaria, according to research published December 1 in Science Translational Medicine. The results promise to spur the future development of next-generation malaria vaccines. Read More
Conferences
International Society for Cell and Gene Therapy Annual Meeting
May 4 - June 7
San Francisco, California United States
Interphex 2022 Conference
May 24-26
New York, New York United States
American Society for Mass Spectrometry Annual Conference
June 5-9
Minneapolis, Minnesota United States
American Society for Microbiology Microbe Meeting
June 9-13
District of Columbia United States
HPLC 2022
June 18-23
San Diego, California United States
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