Cell Biology
Reverse genetics allows researchers to map SARS-CoV-2 in the body
A new study has revealed that SARS-CoV-2 infects the nasal cavity to the greatest degree and infects and replicates progressively less well in cells lower in the respiratory tract. The work, including the development of key laboratory tools, has been accepted by Cell.  Discuss
Multiple recombination events may have led to SARS-CoV-2 in humans
A team of scientists evaluating how SARS-CoV-2 jumped to humans found that several genetic recombination events made it especially well-suited to infect humans, according to a study published in Science Advances on May 29.  Discuss
FDA researchers describe lessons learned from COVID-19 immunology
Key immunological factors underlying the clinical stages of COVID-19 that could be targeted by therapeutic drugs were outlined in a review by U.S. Food and Drug Administration (FDA) researchers and published in Frontiers in Immunology on May 29.  Discuss
New repository may speed COVID-19 drugs to market
As researchers race to find vaccines and treatments for COVID-19, drug repurposing has emerged as potentially the fastest route to get drugs to market. A new research effort aims to speed up the process by creating a repository for data on drugs that have already been used off-label to treat COVID-19.  Discuss
Italian study links social isolation to elderly COVID-19 cases
A new study of COVID-19 infections in Italy suggests that factors associated with social isolation help explain why Italy's large senior population has been disproportionately affected by the COVID-19 pandemic. The findings were published May 21 in the journal PLOS One.  Discuss
Need for efficiency, COVID-19 vaccine spurs biomanufacturing in 2020
With the urgent need for COVID-19 therapies and vaccines, funding agencies have prioritized biomanufacturing; companies in turn are preparing to ramp up a variety of biologics. The strong demand for bioprocessed medicines in 2020 will continue to drive growth of the industry.  Discuss
Will SARS-CoV-2 become an endemic seasonal coronavirus?
U.K. virologists have reviewed over 40 studies on SARS-CoV-2 immunity and discussed how this current knowledge about immune responses can inform virus control strategies. They shared their analysis in an article published in the Journal of General Virology on May 20.  Discuss
New platform includes biological similarities to accelerate drug discovery
A new open-access tool provides information on the effects of nearly 1 million compounds in a wide range of biological settings. The new tool, published in Nature Biotechnology on May 18, may change the drug discovery process by moving beyond reliance on chemical information alone.  Discuss
Academic lab quickly converts to perform SARS-CoV-2 testing
Academic labs could be converted to perform clinical work and process SARS-CoV-2 diagnostic assays with rapid turnaround times to meet increased demand for testing during the COVID-19 pandemic. Investigators from Boston University and Boston Medical Center provided an outline of how they adapted a lab in an article published online May 10 in Med.  Discuss
Human enzymes are implicated in SARS-CoV-2 evolution and spread
Two human deaminase enzymes that edit viral RNA inside cells could have implications for the evolution of SARS-CoV-2 and the spread of the infection, according to a study published in Science Advances on May 18.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
General Discussion
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