Cell Biology
Blocking some T cells may unleash full power of immune system against cancer
Researchers have identified a way to restrict regulatory T-cell activity in tumor cells, which in turn can unleash other immune cells to attack tumors in cancer patients. The research is being published in the August 3 issue of the Proceedings of the National Academy of Sciences. Read More
Bio-Techne launches multiplex spatial genomics assay
Bio-Techne has expanded its RNAscope in situ hybridization technology portfolio with the release of the new RNAscope HiPlex V2 assay for formalin-fixed, paraffin-embedded and fixed and frozen samples for up to 12 targets. Read More
Cells sense repetitive mechanical forces through 'molecular clutch'
A phenomenon known as a "molecular clutch" allows cells in the body to detect the constant mechanical forces they experience, yet the mechanisms for this phenomenon are poorly understood. Now, in a study published recently in Nature Communications, researchers have shown that the frequency of forces can significantly alter the effect on cells. Read More
Researchers fight drug-resistant bacteria with antibiotic 'Trojan horse'
In the latest chapter of the arms race between scientists and drug-resistant bacteria, scientists have devised an antibiotic-filled "Trojan horse" that penetrates deep into the patient's target tissues before unleashing an antibiotic payload on unsuspecting bacterial invaders. The methodology was described July 19 in eLife. Read More
Researchers capture new ribosome structures in motion
Researchers have captured six new structures of the ribosome and its directional movement using single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy. The results were published in Nature on July 7. Read More
Researchers image mouse brain in entirety with multimodal pipeline
Researchers have successfully combined multiple imaging modalities on the same brain tissue to capture the anatomic features of neurons across the entire mouse brain. The pipeline of imaging modalities and results are detailed in NeuroImage. Read More
Machine learning helps scientists map the mammalian immune system
The use of advanced machine-learning software has led to the identification of hundreds of new genes that likely affect the working immune system, according to findings from a study published recently in the Proceedings of the National Academy of Sciences of the United States of America. Read More
Innovation in single-cell sequencing unlocks 10x more data from each cell
A new single-cell sequencing method yields at least 10 times more data for each individual cell compared to previous techniques. The method, published in Nature Biotechnology on July 5, may help cancer researchers uncover new insights into the biological underpinnings of cancer such as drug resistance. Read More
Algorithm expands what scientists can uncover from individual cells
A new software tool can help researchers further utilize single-cell RNA sequencing data to learn more about individual cells by incorporating biologically relevant data into the analysis. The machine-learning algorithm, detailed in Genome Research on June 30, can be used to predict which transcription factors are most active in individual cells. Read More
What makes immunotherapies successful in one tumor but not in others?
Researchers have developed a new framework to uncover pathophysiological and molecular features that determine the effectiveness of immunotherapies. The research, published in Nature Communications on June 29, provides an opportunity for improving patient care and gaining a deeper understanding of cancer immunotherapy mechanisms. Read More
Conferences
CPhI North America
August 10-12
Philadelphia, Pennsylvania United States
Bioprocessing Summit
August 16-19
Boston, Massachusetts United States
6th Annual CAR-TCR Summit
August 30 - September 2
Online
European Congress of Immunology (ECI) 2021
September 1-4
Belgrade Serbia
Medical Affairs Strategic Summit (MASS)
September 13-15
New Brunswick, New Jersey United States
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