Cell Biology
SARS-CoV-2 hijacks lung cells for its own purposes
The first map of molecular responses of human lung cells to SARS-CoV-2 infection has been developed. It shows that the novel coronavirus causes significant protein and phosphorylation damage, effectively hijacking lung cells to enable its entry and propagation, according to a study published in Molecular Cell.  Discuss
Researchers cook up 'recipes' for stem cell programming
Transcription factors (proteins that control gene expression) can be used in simple "recipes" to easily convert stem cells into hundreds of different cells and tissues, according to a new study published in Nature Biotechnology on November 30.  Discuss
Superspreader events drive global SARS-CoV-2 transmission
So-called "superspreader events" have been a major contributor to widespread transmission of the SARS-CoV-2 virus, according to a new analysis of outbreaks in Austria. Researchers used deep viral genome sequencing to trace the evolution of the pandemic in the country and how the virus spread beyond its borders, according to a study published in Science Translational Medicine on November 23.  Discuss
What are the unresolved questions about SARS-CoV-2 T-cell responses?
Researchers have shed light on the "known unknowns" of preexisting and acquired T-cell responses in relation to SARS-CoV-2 infection. In a perspective piece, published in Science Immunology on November 18, scientists from Karolinska Institutet in Sweden discuss the role and durability of T-cell responses in COVID-19.  Discuss
Metabolic control of Tregs is critical for immune tolerance
A new study identifies how metabolism exerts control over regulatory T (Treg) cells, which play a key role in the recognition of foreign and self-produced molecules. The findings, published in Cell Metabolism on November 17, may help scientists identify new drug targets for autoimmune diseases and cancers.  Discuss
Interactive virtual reality system helps drug designers fight COVID-19
A new virtual reality tool offers scientists a chance to "step inside" the SARS-CoV-2 virus's main enzyme responsible for replication and manipulate it in atomic detail to find ways to shut it down. The technology could enable researchers in different locations to collaborate on drug development within a virtual environment.  Discuss
Improving the safety of gene therapies 2 different ways
Two groups of researchers have developed unique approaches to overcome the limitations of delivery of gene editing therapeutics. In a pair of new papers, researchers describe methods for more efficient and safe delivery of CRISPR components to targeted cells and tissues.  Discuss
Digital microfluidic technique connects cells to their environment
A new digital microfluidic technique allows researchers to connect physical cell properties with the molecular makeup of individual cells. This new approach, published in Nature Communications on November 11, will enable a deeper study of stem cells and other rare cell types for therapeutic development.  Discuss
Proteomic changes in cancer cells provide new drug insights
Large-scale profiling of protein changes in response to drug treatment in cancer cell lines has been demonstrated as a powerful tool to predict drug sensitivity, understand drug resistance, and identify optimal drug combinations. The analysis was published in Cancer Cell on November 5.  Discuss
Synthetic nanobodies show potential for new COVID-19 therapies
Synthetic nanobodies may provide a practical avenue for the development of novel COVID-19 therapies compared to human antibodies, which are bulkier and require greater research investment. A study on synthetic nanobodies was conducted by a group of German researchers and published in Nature Communications on November 4.  Discuss
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Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
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