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Is nanomedicine a feasible option for the pharmaceutical industry? – from the 4th Peptide Drug Design & Delivery Summit
September 12, 2019 -- The use of nanoparticles in the pharmaceutical industry is a topic of hot debate among scientists. At the 4th Annual Peptide Drug Design and Delivery Summit, August 27 -29 in Philadelphia, PA, researchers discussed the merits and challenges of incorporating these molecules into therapies.  Discuss
Science Board Member Spotlight: Mona Batish, PhD
September 11, 2019 -- The Science Advisory Board is pleased to bring you a new series that focuses on the most essential part of the scientific process: you!
Germline genetic testing in breast cancer patients may lead to increased therapy options
September 11, 2019 -- Genetic testing for metastatic breast cancer patients may play a key role in identifying additional patients with increased risk and their response to targeted therapies.  Discuss
Breakthrough electrochemical technique may bring cost savings to drug companies
September 10, 2019 -- Researchers have developed a simple new method for the creation of hindered ether compounds, which are often important components of many drugs and commercial products. Hindered ethers have been traditionally difficult to manufacture, but scientists at Scripps Research have published a new electrochemistry technique in Nature on September 9, which allows these compounds to be produced faster and more efficiently.  Discuss
New targeted therapy for lung cancer using precious metals as Trojan exosomes
September 9, 2019 -- Researchers at the University of Edinburgh and the Universidad de Zaragoza in Spain present a novel therapeutic approach to treating cancer on September 9. The research using exosome-directed catalyst prodrug therapies was published in Nature Catalysis.  Discuss
The drug development industry is hungry for 3D printing – from the 4th Peptide Drug Design & Delivery Summit
September 6, 2019 -- The Science Advisory Board attended the 4th Annual Peptide Drug Design and Delivery Summit in Philadelphia from August 27 to 29. One of the most discussed topics at the event of the use of 3D printing for pharmaceutical applications. Many scientists are pursuing this technology with gusto, utilizing the technology to improve peptide drug design.
Study identifies new therapeutic targets to help patients with lung cancer
September 5, 2019 -- A research team at Johns Hopkins University identified new therapeutic targets that will help increase the efficacy of current immunotherapies and reduce the side effects in patients with lung cancer. The results of this clinical study were published in The Journal of Clinical Investigation on September 4.  Discuss
New populations of lung cells identified which could aid in the treatment of chronic respiratory diseases
September 4, 2019 -- New research confirms the existence of two new subpopulations interstitial macrophages (IM), which are crucial to the pulmonary immune system. Published in Nature Communications on August 3, researchers from the Immunophysiology Laboratory of the GIGA Institute at the University of Liege provide insights into the characterization of these IM.  Discuss
Vaccine in development against hypervirulent Klebsiella
August 28, 2019 -- Concerns arising over the development of hypervirulent strains of Klebsiella pneumoniae have led researchers to develop an entirely new vaccine to protect against the gram-negative bacteria. A team of researchers at Washington University School of Medicine in St. Louis and VaxNewMo (a startup based in St. Louis) designed the vaccine by genetically manipulating E. coli. The details of the prototype designed were published in the Proceedings of the National Academy of Sciences on August 27th.  Discuss
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
August 26, 2019 -- A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th.  Discuss
Fluorescent molecular probe used to detect temperature inside individual cells
August 23, 2019 -- Modified biocompatible molecular rotor, termed boron dipyrromethene (BODIPY), has been shown to detect temperatures inside single cells. Researchers at Rice University led by chemist Angel Martí published the technique in the Journal of Physical Chemistry B.  Discuss
Making the leap from academia to industry
August 22, 2019 -- Based on our findings from last year’s career study, it turns out that many scientists have thought about moving from an academic lab setting to a life science industry environment. Whether the reason is to seek new opportunities, avoid internal politics, lab work exhaustion, or even a general loss of interest, scientists worldwide find themselves wondering how they can make the leap from bench to desk and beyond.  Discuss
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