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Dietary probiotics show potential to reverse Parkinson's symptoms
January 14, 2020 -- Roundworms that were fed a commercially available dietary probiotic showed less buildup of proteins that form during the progression of Parkinson's disease in a new study, published in Cell Reports on January 14. The finding provides further evidence of a link between the gut microbiome and brain function.  Discuss
Research sheds light on how bacteria 'take one for the team'
January 13, 2020 -- It's already known that bacteria under assault by phages can occasionally program themselves to die before they become infected. But a pair of new papers published January 10 in Molecular Cell sheds more light on the process by which bacteria "take one for the team." The findings could provide new avenues in the treatment of multidrug-resistant bacterial infections.  Discuss
Scientists in the Lab: Featuring Nicole Lindor
January 13, 2020 -- ScienceBoard is happy to continue to feature scientists in the lab this month. The next scientist we are featuring is Nicole Lindor, a doctoral candidate at North Carolina State University.  Discuss
Control of molecular 'doormen' in fat cells offers potential new obesity treatment
January 10, 2020 -- New treatment options for obesity could emerge from a study published in Nature Communications on January 10. Researchers from Yale University School of Medicine utilized cellular and molecular approaches to identify pathways to restore the healthy balance of fat cells.  Discuss
Bacterial evolution reveals method to fight antibacterial resistance
January 9, 2020 -- Different types of bacteria have evolved to develop unique mechanisms for achieving the same antibacterial function -- a finding that could lead to new ways to combat antibacterial resistance, according to scientists from Trinity College Dublin. They tested their findings using methicillin-resistant Staphylococcus aureus in a study that was published in Nature Communications on January 9.  Discuss
Scientists in the Lab: Featuring Rebecca Fleeman
January 8, 2020 -- This month, ScienceBoard is featuring scientists in the laboratory to celebrate their important contributions to the scientific community. We are excited to introduce our first featured scientist of this month, Rebecca Fleeman of Penn State College of Medicine in Hershey, PA.  Discuss
Nanoparticles direct 'suicide genes' to treat brain tumors in children
January 8, 2020 -- Researchers from Johns Hopkins University report a bioengineered nanoparticle that successfully delivers a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. Details of the nanoparticle treatment were published in the January 2020 edition of Nanomedicine: Nanotechnology, Biology and Medicine.  Discuss
Improving melanoma immunotherapies by regulating Treg proliferation
January 7, 2020 -- A new pathway to regulating anti-tumor immunity and increasing the effectiveness of PD-1 therapies was identified by scientists at Sanford Burnham Prebys Medical Discovery Institute. The results were published in Nature Communications on January 7.  Discuss
Researchers elucidate mechanotransduction pathways of transmembrane proteins
January 6, 2020 -- Researchers from Imperial College London, Queen Mary University of London, and Tampere University in Finland present new mechanistic pathways for transmembrane proteins with implications in drug discovery and development. The results of the study were published in Nature Materials on January 6.  Discuss
Together, machine learning and tumor DNA provide new tools for colorectal cancer patients
January 2, 2020 -- Researchers utilize a new machine learning platform to identify patients with colorectal cancers and predict their disease severity and survival. The study, published in Science Translational Medicine on January 1, involves samples from over a thousand patients.  Discuss
Top 10 ScienceBoard stories of 2019
January 2, 2020 -- As you may have noticed, there were quite a few changes to ScienceBoard in 2019. In the second half of the year, we brought more targeted content for life scientists, particularly research news. We saw that advances in molecular biology and genomics, along with a focus on the development of new therapies for a variety of diseases.  Discuss
Precision medicine and molecular understanding of illness
December 23, 2019 -- The current era of scientific research is seen by many as a golden age of discovery in genetics, due to rapid progress in numerous areas of science and technology. While healthcare and the pharmaceutical industry traditionally have directed their attention to symptoms rather than underlying causes, the new advances are creating opportunities to better exploit a rapidly expanding mechanistic understanding of disease. The challenges are significant and complex, and the current models of discovery and translation do not provide an obvious path toward an economically sustainable way to integrate data-intensive biology with medicine.  Discuss