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Help inform tools and technologies that advance research, treatments, and cures. The Science Advisory Board is an exclusive, online community that connects scientific and medical professionals across the world.

The Science Advisory Board is an exclusive, online community that connects scientific and medical professionals across the world.

New imaging technique gains an advantage with deep learning software
November 13, 2019 -- Researchers from Rensselaer Polytechnic Institute developed a new technique that applies deep learning to quantify images generated from fluorescence lifetime imaging. Details of the deep neural network they developed, called FLI-Net, are described in the November 12 issue of the Proceedings of the National Academy of Sciences.  Discuss
Is there a reproducibility problem with RNA-seq data?
November 12, 2019 -- Modern day technology has allowed scientists to analyze highly complex genomic data sets. However, with this comes increased challenges associated with reproducibility and misinterpretation of results from massive data sets. One such example, RNA sequencing (RNA-Seq), provides the ability to simultaneously measure gene expression levels of all genes in a sample in a single test.  Discuss
Targeted therapies can now be more effective with the use of ultrasound technology
November 12, 2019 -- Biomedical engineers from the University of Southern California in Los Angeles propose a new method to direct targeted drug release in the body using acoustics. The findings describing how they manipulated ultrasonic waves were published in Applied Physics Letters on November 12, 2019.  Discuss
Novel mitochondrial phenomenon helps explains early neurodegeneration
November 8, 2019 -- Northwestern University Feinberg School of Medicine scientists discovered a novel pathway that leads to neurodegeneration in amyotrophic lateral sclerosis (ALS). The study was published in Frontiers in Cellular Neuroscience on November 7. The pathway could explain the development of early stages of neurodegeneration which affects voluntary muscle movement such as walking and talking.  Discuss
Modified CRISPR system aims to improve therapies for HIV, sickle cell disease
November 8, 2019 -- Researchers from City of Hope have improved the CRISPR-Cas9 system through novel sequence changes to the trans-activating RNA (tracrRNA). The improved tool could help to fast track new therapies for HIV, sickle cell disease and other immune conditions. The results were published in Scientific Reports on November 6.  Discuss
New nanoparticles help reduce inflammatory disease
November 7, 2019 -- Researchers from Washington State University have discovered a potential new treatment option for diseases associated with inflammation. The study, published in Science Advances on November 6, describes a new patent-pending nanotechnology that specifically targets activated neutrophils that compromise the immune system.  Discuss
Liver-Chip can now determine human-specific toxicities
November 6, 2019 -- A group of academic and industry researchers developed new Liver-Chips with four cell types found in the livers of rats, dogs, and humans. The idea was generated at Wyss Institute for Biologically Inspired Engineering at Harvard and then transferred to Emulate Inc., to provide real-time analysis of complex biochemical interactions and enhanced liver toxicity testing.  Discuss
Novel enzyme structure discovered by scientists
November 6, 2019 -- A research team at the University of California, Riverside, has discovered the structure of a novel RNA-modifying enzyme and identified the mechanism that controls substrate specificity. The study was published in Nature Communications on November 6 and explains how protein machinery in cells is regulated to target RNA molecules for modification.
Novel strategy for studying mitoribosomal and mitochondrial impact on disease
November 5, 2019 -- Researchers from the Karolinska Institutet in Sweden have developed a new experimental tool for studying mitochondrial protein synthesis in vivo. This research is presented in the October 5 issue of Cell Reports.  Discuss
Cutting edge microscopy technique leads to new insights in cancer
November 1, 2019 -- New research published in the October 31 edition of Science debuts a new technique for creating high-resolution visual maps of the chromatin structure remodeling (RSC) complex to further understand its role in healthy and cancer cells. This research was led by Bradley Cairn, PhD, cancer researcher at Huntsman Cancer Institute and professor and chair of oncological sciences at the University of Utah.  Discuss
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