Analytical Chemistry
Faster fluid mixing could reduce costs for silica microparticles
A surprisingly simple approach to manufacturing silica nanoparticles by taking advantage of fluid dynamics in tiny Teflon tubes could reduce manufacturing costs. The work is described in a June 28 article published in the Chemical Engineering Journal.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
Some viruses may steal host genes to form beneficial hybrid proteins
Certain types of RNA viruses may be capable of using host RNA to expand their own genetic repertoire, according to a new study published in Cell on June 18. This mechanism may enable viruses to overcome the limitations of small genomes and more effectively infect host cells.  Discuss
Manufacturers adapt technologies for hand sanitizers during COVID-19
Changes to manufacturing processes have emerged to meet the demand of certain products during the COVID-19 pandemic, including hand sanitizer. The chemical composition of hand sanitizer is carefully regulated, and analytical techniques are now being repurposed to assist in rapid production efforts.  Discuss
Need for efficiency, COVID-19 vaccine spurs biomanufacturing in 2020
With the urgent need for COVID-19 therapies and vaccines, funding agencies have prioritized biomanufacturing; companies in turn are preparing to ramp up a variety of biologics. The strong demand for bioprocessed medicines in 2020 will continue to drive growth of the industry.  Discuss
Proteomics provides insights into SARS-CoV-2 infection, potential therapies
Scientists tested a series of compounds for blocking the replication of SARS-CoV-2 using a novel proteomics approach. The method, which helped identify small-molecule drugs that may be effective at treating COVID-19 patients, was published in Nature on May 14.  Discuss
Moving closer to orally dosed peptide medications
A new method can identify among billions of double-bridge peptides the ones that are most likely to bind to disease targets of interest and escape enzymatic degradation in the gastrointestinal tract. A study on the method was published in Nature Biomedical Engineering on May 11.  Discuss
An update on RNA extraction kit supply due to COVID-19
The extraordinary demand for COVID-19 polymerase chain reaction testing has strained the production capabilities of vendors in the nucleic acid preparation market. Several vendors are reporting skyrocketing demand for RNA extraction kits and other COVID-19-related products.  Discuss
New STM technique could lead to purer pharmaceuticals
A research project led by chemists at the University of Warwick has revealed how ultrahigh-resolution scanning tunneling microscopy (STM) can be used to determine precise molecular interactions, which could be particularly useful for the production of raw materials. The report was published in Nature Communications on April 30.  Discuss
COVID-19: A double-edged sword for the pharma industry
The COVID-19 pandemic is causing major disruptions to pharmaceutical R&D activities, despite the pressing need for treatments and diagnostics for the novel coronavirus. In a new article, Ivan Gandayuwana of Strategic Directions International examines the multiple impacts COVID-19 is having on pharma.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
General Discussion
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