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Breakthrough electrochemical technique may bring cost savings to drug companies
September 10, 2019 -- Researchers have developed a simple new method for the creation of hindered ether compounds, which are often important components of many drugs and commercial products. Hindered ethers have been traditionally difficult to manufacture, but scientists at Scripps Research have published a new electrochemistry technique in Nature on September 9, which allows these compounds to be produced faster and more efficiently. Read More
New targeted therapy for lung cancer using precious metals as Trojan exosomes
September 9, 2019 -- Researchers at the University of Edinburgh and the Universidad de Zaragoza in Spain present a novel therapeutic approach to treating cancer on September 9. The research using exosome-directed catalyst prodrug therapies was published in Nature Catalysis. Read More
The drug development industry is hungry for 3D printing – from the 4th Peptide Drug Design & Delivery Summit
September 6, 2019 -- The Science Advisory Board attended the 4th Annual Peptide Drug Design and Delivery Summit in Philadelphia from August 27 to 29. One of the most discussed topics at the event of the use of 3D printing for pharmaceutical applications. Many scientists are pursuing this technology with gusto, utilizing the technology to improve peptide drug design. Read More
Study identifies new therapeutic targets to help patients with lung cancer
September 5, 2019 -- A research team at Johns Hopkins University identified new therapeutic targets that will help increase the efficacy of current immunotherapies and reduce the side effects in patients with lung cancer. The results of this clinical study were published in The Journal of Clinical Investigation on September 4. Read More
New populations of lung cells identified which could aid in the treatment of chronic respiratory diseases
September 4, 2019 -- New research confirms the existence of two new subpopulations interstitial macrophages (IM), which are crucial to the pulmonary immune system. Published in Nature Communications on August 3, researchers from the Immunophysiology Laboratory of the GIGA Institute at the University of Liege provide insights into the characterization of these IM. Read More
Vaccine in development against hypervirulent Klebsiella
August 28, 2019 -- Concerns arising over the development of hypervirulent strains of Klebsiella pneumoniae have led researchers to develop an entirely new vaccine to protect against the gram-negative bacteria. A team of researchers at Washington University School of Medicine in St. Louis and VaxNewMo (a startup based in St. Louis) designed the vaccine by genetically manipulating E. coli. The details of the prototype designed were published in the Proceedings of the National Academy of Sciences on August 27th. Read More
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
August 26, 2019 -- A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th. Read More
Fluorescent molecular probe used to detect temperature inside individual cells
August 23, 2019 -- Modified biocompatible molecular rotor, termed boron dipyrromethene (BODIPY), has been shown to detect temperatures inside single cells. Researchers at Rice University led by chemist Angel Martí published the technique in the Journal of Physical Chemistry B. Read More
Making the leap from academia to industry
August 22, 2019 -- Based on our findings from last year’s career study, it turns out that many scientists have thought about moving from an academic lab setting to a life science industry environment. Whether the reason is to seek new opportunities, avoid internal politics, lab work exhaustion, or even a general loss of interest, scientists worldwide find themselves wondering how they can make the leap from bench to desk and beyond. Read More
Oncogene identified as a therapeutic target for liver cancer
August 22, 2019 -- The function of an enzyme that is highly expressed in many cancers has been revealed to regulate key pathways in cancer metabolic adaptation. Researchers at the Georgia Cancer Center and Medical College of Georgia at Augusta University published their findings in Hepatology. Read More
New drug target identified for common brain cancer
August 21, 2019 -- Research led by the Cleveland Clinic has identified a potential new therapy in the treatment of glioblastoma. An article published in Cancer Discovery on August 21, identifies FGF2 (fibroblast growth factor 2), as a novel drug target for glioblastoma, the most common primary malignant brain tumor. Read More
Genomic and microbial analyses reveal microbe independently degrades oil to gas
August 20, 2019 -- Methanoliparia, an archaea found in deep within oil reservoirs, may degrade oil to methane all by itself. Researchers from the Max Planck Institute for Marine Microbiology in Bremen, Germany and the MARUM, Centre for Marine Environmental Sciences provide genomic and microbial evidence of Methanoliparia’s ability to transform long-chain hydrocarbons to methane. The results were published in mBio on August, 20. Read More
Biologically active molecules in coal are found to have antiviral properties against tick-borne encephalitis
August 19, 2019 -- Scientists from Russia demonstrated in a Scientific Reports article published on August 19, that biologically active molecular components of substances extracted from coal, humic substances, have antiviral properties. A novel approach to identify these molecules determined that these molecules inhibit the reproduction of tick-borne encephalitis virus (TBEV), which causes clinically relevant human viral infectious disease. Read More
Super-resolution using standard optical microscopes now possible with the aid of upconversion nanoparticles
August 16, 2019 -- Researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) in Australia have found an innovative way to utilize standard laboratory optical imaging equipment to bypass diffraction limitations and achieve super-resolution. Results published in Nature Communications on August 16 provide methodology and theoretical framework for end-users to achieve super-resolution in their own laboratories. Read More
Top scientists ousted – potential impacts on mistrust of scientists in the US
August 15, 2019 -- Novartis dismissed the top two scientists at its gene therapy division shortly after CEO, Vas Narasimhan, learned of internal data falsification. This controversy comes at a time of high public trust in science and threatens to break that trust with scandals and safety concerns. Read More
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