A*STAR partners with startup to create diabetes cell therapies tailored to Asian patients
BetaLife has acquired the rights to human induced pluripotent stem cell (iPSC) technology from Singapore’s Agency for Science, Technology, and Research (A*STAR) for use in the treatment of diabetes. Read More
Neutrophil culprits cause pancreatic cancer treatment resistance
Researchers have discovered how immature neutrophils -- white blood cells that are an important part of the immune system -- are hijacked by pancreatic cancers to drive treatment resistance. The study, published Wednesday in Cancer Discovery, may facilitate new pancreatic cancer treatment avenues. Read More
Contagious fungal infections increase dramatically
According to national surveillance data, candidiasis cases caused by Candida auris, a highly infectious fungus, rose drastically between 2019 and 2021, reflecting increased transmission. Read More
Gestational diabetes rise linked to screening practices
A Canadian Medical Association Journal study published Monday found that although gestational diabetes is reportedly on the rise, changes in screening practices may largely explain the increase. Read More
Implication of nervous system in anaphylaxis opens ways to treat severe allergic reactions
Heat-sensing neurons are key contributors to severe allergic shock reactions, according to a study in mice that points to ways to reverse life-threatening symptoms. Read More
Clinical investigators need to be wary of confounding and bias in real-world studies; here is what to look for and how to address it
Clinical investigators use real-world data (RWD) in randomized trials and observational studies to produce real-world evidence (RWE) used to assess the safety and efficacy of an intervention and to inform product development, regulatory approval, and post-market surveillance efforts. Read More
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity. Read More
Gene-editing reverses vision loss in mice
Researchers in China successfully restored the vision of mice with retinitis pigmentosa, a major cause of blindness in humans. The research, published Friday in the Journal of Experimental Medicine, describes a new form of CRISPR-based genome editing which has the potential to correct a variety of disease-causing genetic mutations. Read More
HIV potentially cured by transplanting umbilical cord stem cells in mixed race woman
Transplanting stem cells from umbilical cord blood has potentially cured a mixed-race woman of HIV and freed her from taking antiviral medication, according to a case report published in Cell. Read More
Simpler, cheaper screening method developed to democratize COVID-19 drug discovery
An alternative method for finding single-chain antibodies has yielded COVID-19 drug candidates that may be effective against variants of concern. Read More
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