Enzyme-activated drug candidate points to new way to treat liver cancer
Small molecules that are activated by an enzyme produced by some tumors could improve the treatment of liver cancer, a study run by scientists at the National Institutes of Health (NIH) and Massachusetts General Hospital suggests. Read More
GHIT Fund provides $1.9M for malaria drug development
The Global Health Innovative Technology (GHIT) Fund on Monday announced approximately $1.9 million (260 million yen) in funding for the research and development of a new malaria drug. Read More
A new immune pathway sheds light on ALS
A study indicates that inflammatory proteins involved in the innate immune system cause neuron damage and play a role in neurodegenerative diseases. Read More
Therapeutic target may aid in glaucoma treatment
Indiana University School of Medicine researchers have identified a new therapeutic target that could lead to more effective glaucoma treatment. The research, published recently in Communications Biology, found that restoring mitochondrial homeostasis in diseased neurons can protect optic nerve cells from being damaged. Read More
Pfizer to acquire Seagen for $43 billion
Pfizer will acquire Seagen, a firm specializing in the discovery and development of treatments for cancer, the firms announced on Monday. Read More
Exclusion of racial groups from cancer genomics research has negative impacts
The lack of genomic research for people with African ancestry is hampering efforts to reduce health disparities for people with cancer, according to recent research. Read More
Correlation of enzyme to survival reveals potential target for metastatic solid tumors
The enzyme lysyl hydroxylase 1 (LH1) promotes the migration and metastasis of solid tumor cells and is associated with shorter survival, according to a recent study published in Molecular Cancer. Read More
Protein expression biomarker may identify likely responders to potential breast cancer drug
Targeting women who express certain proteins could increase the response rate to a breast cancer drug that achieved mixed results in previous clinical trials, according to a paper published in EMBO Molecular Medicine. Read More
Modifying messenger RNA provides new Alzheimer’s disease target
Researchers in China have found that reducing the methylation of a key messenger RNA can promote the migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in mice. Read More
Study supports genetic testing for people with cerebral palsy
A meta-analysis of recent research on the genetics of cerebral palsy provides evidence that genetic testing should be offered as the standard of care for people with the disorder. Read More
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