Cancer & Disease Research
Scientists create atlas of mouse brain regions down to single cells
An atlas of the mouse cerebrum and primary motor cortex down to the level of single cells was published in a pair of papers on October 6 in Nature. The research reveals the mammalian brain's organization at an unprecedented level of detail and sheds new light on gene regulatory factors, promising to inform future work on developing targeted therapies for human diseases. Read More
Scientists release open-source platform for large-scale biological simulations
A team of scientists has released BioDynaMo, an open-source simulation platform for the life sciences. The new computational tool can perform complex simulations of biological processes in fields such as neuroscience, oncology, and epidemiology. The software was detailed in a paper published on September 16 in Bioinformatics. Read More
Next-generation gene therapy points to base editing
Base editing has emerged as a new player in the gene therapy arena, with rapid advances in technology and evidence of proof of concept in rare genetic disease and beyond. Read More
'Minibrains' grown from stem cells replicate brain's electrical activity
Researchers have grown 3D human brain tissue from stem cells that replicates the patterns of electrical activity found in the brains of patients with Rett syndrome. These "minibrain organoids" can be used to investigate the underlying causes of neurological disease and screen and test potential drug candidates, according to research published on August 23 in Nature Neuroscience. Read More
Researchers create 3D tumor models with cells from patients
Using tissue samples from cancer patients, Israeli researchers have successfully printed an active, viable glioblastoma 3D tumor model. In addition to potential applications in personalized medicine, the achievement promises to speed drug development and increase the chances that developed drugs will succeed in clinical trials. The results were published August 18 in Science Advances. Read More
Long-read sequencing of circRNA finds autism-linked microexons
Scientists have developed a new laboratory protocol and bioinformatic pipeline using a long-read sequencing platform from Oxford Nanopore Technologies for exploring the composition of circular RNA (circRNA). The technique, published on August 10 in Nature Communications, showed that a group of microexons that had been previously linked to autism are preferentially found in circRNA. Read More
Antisense oligonucleotide therapies get delivered across the blood-brain barrier
Researchers have demonstrated that heteroduplex oligonucleotide drugs conjugated with cholesterol efficiently cross the blood-brain barrier and can be used to treat central nervous system diseases. The findings were published in Nature Biotechnology on August 12. Read More
Voyager advances gene therapy platform for CNS diseases
Voyager Therapeutics has launched new gene therapy programs for Huntington's disease, amyotrophic lateral sclerosis caused by mutation in the SOD1 gene, spinal muscular atrophy, and diseases linked to glucosylceramidase beta mutations, powered by its proprietary adeno-associated virus capsids. Read More
Researchers identify chronic stress gene target in brain
By studying how genes affect receptors in the brain under stress, researchers have discovered new molecular mechanisms behind the function of corticosterone, the stress hormone. The research was published in Nature Communications on August 6. Read More
Regeneron announces creative innovation 2021 winners
Regeneron announced the winners of its ninth annual Regeneron Prize for Creative Innovation, a competition designed to recognize creativity and independent scientific thinking among postdoctoral fellows and graduate students focused on biomedical research. This year's winners included Sergey Stavisky, PhD, of Stanford University and Nitsan Goldstein of the University of Pennsylvania. Read More
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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