Cancer & Disease Research
Optogenetic gene therapy provides hope for retinitis pigmentosa patients
Optogenetic therapy bypasses traditional methods of repairing defective photoreceptors in the eye by targeting other retinal cells. Recently, three examples of optogenetic therapeutics under development highlight many of the challenges this type of gene therapy faces for the treatment of a devastating genetic eye disease. Read More
Gene therapy tackles 2 rare childhood diseases 2 different ways
Two new studies point to the efficient use of gene therapy to treat deadly childhood genetic diseases. The first study used direct gene therapy infusion to treat a rare neurodevelopmental disorder, while the second study used prenatal base editing in mouse models as proof of concept for the treatment of genetic diseases. These vastly different approaches show the promise of gene therapy for a variety of devastating diseases. Read More
Researchers image mouse brain in entirety with multimodal pipeline
Researchers have successfully combined multiple imaging modalities on the same brain tissue to capture the anatomic features of neurons across the entire mouse brain. The pipeline of imaging modalities and results are detailed in NeuroImage. Read More
Collaboration targets new treatments for brain diseases
Developing more effective methods to deliver drugs across the blood-brain barrier is the goal of a new collaboration being led by the Wyss Institute for Biologically Inspired Engineering at Harvard University. Read More
How spatial biology can impact clinical translational research
Building on the success of single-cell technologies, 10X Genomics' Michael Schnall-Levin, PhD, discusses with ScienceBoard.net how the company entered the spatial biology field and how it continues to support the advancement of various clinical translational research efforts. Read More
Quantitative image analysis provides confidence in drug development
Olga Kubassova, PhD, CEO of Image Analysis Group, spoke with ScienceBoard.net about how computational analysis is improving clinical trial imaging. Read More
Life science microscopy techniques get AI upgrade
Artificial intelligence (AI) can be used to speed up the computationally intensive process of light-field microscopy, a 3D microscopic imaging method. Researchers who developed the technique refer to it as hybrid LFM (HyLFM) and described the method in a paper published on May 7 in Nature Methods. Read More
Life after academia: Industry can offer new opportunities for scientists
For many scientists working in academia, the idea of switching careers to industry can be intimidating. But many scientists are making the move and are finding corporate work to be just as rewarding. One of them is Anuraag Sarangi of medical communications firm Precisionscientia. Read More
New gene therapy could be effective in treating complex polygenic conditions
Scientists are applying gene therapy approaches in a new way by simultaneously administering a combination of cargos to treat complex polygenic neurodegenerative diseases with no single genetic cause. Details of the combination gene therapy in two animal models were detailed in a March 31 Science Advances article. Read More
RNA editing enzyme ADAR1 helps cancer cells proliferate
Researchers have discovered that an isoform of the RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is responsible for regulating genome stability of telomeres at chromosomal ends. The findings, published in Nature Communications on March 12, suggest that the enzyme is required for the proliferation of cancer cells and may be a potential therapeutic target for some cancers. Read More
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