Cancer & Disease Research
Extracellular RNA identifies new Alzheimer's biomarker
The association of extracellular RNA with upregulation of the phosphoglycerate dehydrogenase gene may be a useful presymptomatic biomarker for Alzheimer's disease, according to an article published in Current Biology on March 26.  Discuss
New machinery digests toxic proteins to protect DNA replication
Researchers have identified molecular machinery that helps repair damaged DNA that occurs during DNA replication and transcription. This work, published in Nature Communications on March 9, reveals how specific enzymes "eat" or break down proteins that cause broken DNA.  Discuss
Glia-to-neuron conversion gene therapy can treat Huntington's disease
Using adeno-associated virus technology, researchers have developed a novel gene therapy that can regenerate functional neurons in mouse models of Huntington's disease. The work was published in Nature Communications on February 27.  Discuss
Brain's immune system blocks blood immune cells from healing spinal injuries
Molecular and computational analysis of immune responses in the central nervous system reveals that the brain's immune system may prevent blood immune cells from entering a lesion site after injury. The research, published online in Science Advances on January 15, may offer new avenues to treat certain neurological diseases such as multiple sclerosis, Alzheimer's disease, and spinal cord injury.  Discuss
Stem cell findings help researchers learn about early-onset Parkinson's
New research utilizing stem cells indicates that the metabolic processes that lead to young-onset Parkinson's disease could begin years before symptoms of the disease emerge. But the findings also point to a potential drug candidate that could be used to treat the condition, according to a study published January 27 in Nature Medicine.  Discuss
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration.  Discuss
Dietary probiotics show potential to reverse Parkinson's symptoms
Roundworms that were fed a commercially available dietary probiotic showed less buildup of proteins that form during the progression of Parkinson's disease in a new study, published in Cell Reports on January 14. The finding provides further evidence of a link between the gut microbiome and brain function.  Discuss
Scientists in the Lab: Featuring Rebecca Fleeman
This month, ScienceBoard is featuring scientists in the laboratory to celebrate their important contributions to the scientific community. We are excited to introduce our first featured scientist of this month, Rebecca Fleeman of Penn State College of Medicine in Hershey, PA.  Discuss
Scientists develop a first-of-its-kind in vitro 3D neural tissue model
Researchers from the University of Illinois at Urbana-Champaign have successfully used stem cells to engineer nerve tissues as 3D models of neural networks to study brain function. The work was published in the December 3 edition of the Proceedings of the National Academy of Sciences.  Discuss
Scientists identify chaperones as potential therapies for Parkinson's disease
Researchers from the University of Basel have identified the malfunctional relationship and master regulatory mechanisms between chaperone proteins and α-Synuclein occurring in Parkinson's disease. The findings were published in Nature on December 4.  Discuss
Conferences
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
Lab of the Future USA
May 19-20
Boston, Massachusetts United States
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International
September 21-24
Boston, Massachusetts United States
General Discussion
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