Localized delivery of IL-2 by drug-producing cells eradicates cancer in mice
Implanting beads loaded with cytokine-producing cells eradicates advanced-stage mesothelioma tumors in mice, according to a study published on August 22 in Clinical Cancer Research. Read More
Antiviral-antibody combination improves influenza outcomes in mice
Researchers at McMaster University found in a mouse study that combining a class of well-known antiviral drugs and neutralizing antibodies was more effective than either approach alone, which they contend could be used to treat seasonal influenza and help prevent the next flu pandemic. Read More
Synthesis breakthrough opens door to development of natural product as cancer therapy
Princeton University scientists have halved the number of steps needed to synthesize pleurotin, setting the stage for work to realize the anticancer and antibiotic potential of the molecule. Read More
Scientists discover biomarkers associated with acute, chronic phases of TBI
Arizona State University scientists have provided some of the first detailed view of the molecular and cellular mechanisms behind traumatic brain injury (TBI) as the condition progresses from the acute to the chronic phase. Read More
Current COVID-19 boosters provide protections against serious infection: study
Despite the evolution of the SARS-CoV-2 pandemic coronavirus, a new laboratory study conducted by a team of international researchers suggests current vaccine boosters may elicit sufficient immune protection against severe omicron-induced COVID-19 disease. Read More
CRISPR reveals interconnected map of immune feedback loops, regulatory networks
The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases. Read More
Researchers capture images of antibody attacking neuron receptor
U.S. and German researchers have captured the first images of an antibody attacking a nerve cell surface receptor using cryo-electron microscopy, a technique that freezes proteins in place to get high-resolution microscopic images, according to a study published in Cell. Read More
Protein crystallography links rigid antibody hinges to increased anticancer activity
Researchers at the University of Southampton have gained new insight into the key properties of an antibody needed to fight off cancer using protein crystallography, revealing that the flexibility of the hinge between the arms of IgG2 antibodies affects the anticancer effects triggered by the molecules. Read More
MASTER technology could transform CAR T-cell therapy
A new technology that helps CAR T cells attack cancer cells more aggressively than conventional methods has been published by researchers from North Carolina. Called multifunctional alginate scaffold for T-cell engineering and release (MASTER), the technology was described in a paper published on March 24 in Nature Biotechnology. Read More
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