Immunology Sponsored by Beckman Coulter
Optofluidics aids cell line development for antibody-based therapies
Implementation of optofluidics in cell line development can help advance multiple lead candidate molecules with increased screening capacity. A researcher from GlaxoSmithKline discussed how her team uses an optofluidic system in a June 15 presentation at the BioProcess International Spring Digital Week's 2020 virtual meeting.  Discuss
Are interferons helpful or harmful during SARS-CoV-2 infection?
The host immune system produces a variety of regulatory molecules, including interferons, during a response to viral infection. Although previously considered beneficial, these proteins may actually cause life-threatening inflammation, according to an article published in Science on June 11.  Discuss
FDA researchers explore vaccine responses to SARS-CoV-2 antigens
Different proteins associated with SARS-CoV-2, the virus that causes COVID-19, generate unique immune responses when given to rabbits as immunizations, according to a June 8 Science Translational Medicine article.  Discuss
Transparency helps maintain scientific integrity of clinical trials
A new study offers reassuring evidence about the integrity of registered clinical trials, with researchers finding no signs of widespread manipulation of results regarding statistical significance thresholds. The study results were published in the Proceedings of the National Academy of Sciences on June 2.  Discuss
Pioneering technology stabilizes vaccines at all temperatures
Scientists have identified a new method called ensilication to prevent warmed-up vaccines from degrading. By coating proteins in a silica shell, the structures remain intact and effective. A new study published in Scientific Reports on June 8 expands on previous knowledge about the technique and provides crucial in situ and in vivo evidence for real-world applications.  Discuss
Preclinical innovations can speed COVID-19 drug development
Preclinical testing for drug candidates has remained largely unchanged, despite numerous innovations in cell culture techniques. Researchers discussed how these innovations could help speed drug discovery efforts for the COVID-19 pandemic in an article published in Theranostics.  Discuss
Reverse genetics allows researchers to map SARS-CoV-2 in the body
A new study has revealed that SARS-CoV-2 infects the nasal cavity to the greatest degree and infects and replicates progressively less well in cells lower in the respiratory tract. The work, including the development of key laboratory tools, has been accepted by Cell.  Discuss
FDA researchers describe lessons learned from COVID-19 immunology
Key immunological factors underlying the clinical stages of COVID-19 that could be targeted by therapeutic drugs were outlined in a review by U.S. Food and Drug Administration (FDA) researchers and published in Frontiers in Immunology on May 29.  Discuss
Need for efficiency, COVID-19 vaccine spurs biomanufacturing in 2020
With the urgent need for COVID-19 therapies and vaccines, funding agencies have prioritized biomanufacturing; companies in turn are preparing to ramp up a variety of biologics. The strong demand for bioprocessed medicines in 2020 will continue to drive growth of the industry.  Discuss
Will SARS-CoV-2 become an endemic seasonal coronavirus?
U.K. virologists have reviewed over 40 studies on SARS-CoV-2 immunity and discussed how this current knowledge about immune responses can inform virus control strategies. They shared their analysis in an article published in the Journal of General Virology on May 20.  Discuss
Conferences
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
BioProcess International
September 21-24
Eastern Standard Time Zone (EST), Massachusetts United States
General Discussion
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