Immunology
Inhibiting white blood cell enzyme reduces lung metastases in mice: study
Researchers at The Wistar Institute and Jubilant Therapeutics have found an enzyme in neutrophils that promotes tumor growth and metastasis, pointing to a new way to treat cancers. Read More
Stanford platform improves hunt for antigens that trigger strong immune responses
Researchers at Stanford University have developed a method for making faster, more accurate predictions of which antigens will trigger a strong immune response. Their work could help scientists develop more effective cancer immunotherapies. Read More
Blocking key enzyme boosts anticancer T-cell responses, resistance to immunosuppression
Blocking a key enzyme boosts anticancer T-cell responses and resistance to immunosuppression, according to a mice study from LSU Health New Orleans published August 26 in Frontiers in Immunology. Read More
Oncolytic virotherapy, immunotherapy combo shows promise for treatment-resistant cancers
A combination of oncolytic virotherapy, a technique using cancer-fighting viruses, acting in concert with immunotherapy shows promise for treatment-resistant cancers, according to new research. Read More
Localized delivery of IL-2 by drug-producing cells eradicates cancer in mice
Implanting beads loaded with cytokine-producing cells eradicates advanced-stage mesothelioma tumors in mice, according to a study published on August 22 in Clinical Cancer Research. Read More
First full map of immune system connections unlocks drug discovery opportunities
Researchers have created the first full map of immune system connections showing how immune cells communicate, pointing to ways to modulate the pathways to treat cancer and infectious diseases. Read More
Researchers identify T cells that protect against ischemic stroke in mice
University of Pittsburgh neurologists and immunologists have identified a subset of CD8+ regulatory-like T cells (CD8+TRLs) that provide fast-acting and lasting protection against ischemic stroke in mice, offering a potentially novel immunotherapy for stroke in humans. Read More
3D imaging reveals picture of T-cell activity to unlock solid tumor opportunity
Researchers have used imaging and transcriptomics to identify T cells with potent serial killing capacity in a push to expand use of the immunotherapies to solid tumors. Read More
Single-cell analyses shed light on drug resistance of melanoma brain metastases
Using single-cell genetic analyses of frozen brain samples, Columbia University researchers have uncovered evidence of how melanoma brain metastases evade current treatments. Read More
Machine learning model opens door to real-time detection of cell therapy contamination
Researchers at the Massachusetts Institute of Technology’s Singapore site have developed a new way to detect adventitious microbial contamination in mesenchymal stromal cell cultures. By using machine learning to predict if a culture is contaminated in near real-time, the approach could enable testing to take place during the production of cell therapy products. Read More
Conferences
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
American Association of Pharmaceutical Scientists PharmSci 360 Annual Meeting
October 16-19
Boston, Massachusetts United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
International Society for Pharmaceutical Engineering Annual Meeting
October 30 - November 2
Orlando, Florida United States
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