Immunology
Chikungunya vaccine candidate in clinical trial found generally safe and effective
A study of U.S. adults found that a vaccine candidate for chikungunya disease was generally safe and well tolerated. Read More
HIV nanoparticle vaccine induces strong T-cell responses in early-phase clinical trial
An HIV nanoparticle vaccine has induced strong T-cell responses in a first-in-human clinical trial, marking a step toward the development of a product that protects against the virus. Read More
Clinical trial begins for universal flu vaccine candidate
Researchers at NIH’s National Institute of Allergy and Infectious Diseases (NIAIDs) have developed an experimental universal influenza vaccine. Read More
Discovery of markers on long-lasting immune cells lights way to more durable vaccine responses
Researchers have identified surface markers on cells that continue producing antibodies for a long time, pointing to a way to improve the duration of response to vaccines. Read More
FDA approves first respiratory syncytial virus vaccine
The U.S. Food and Drug Administration (FDA) said Wednesday that it has approved the use of GlaxoSmithKline Biologicals’ Arexvy vaccine for respiratory syncytial virus (RSV). Read More
Specialized printer may help vaccines reach more people
Researchers have developed a specialized printer to generate vaccine-filled microneedle skin patches that can be stored long-term without refrigeration. Their research, published Monday in Nature Biotechnology, may eventually bring more vaccines to more people. Read More
Plasmid DNA vaccine protects mice from COVID-19 by triggering T-cell response
A plasmid DNA vaccine designed to trigger a T-cell response has protected most mice from a lethal dose of SARS-CoV-2, delivering preliminary evidence that the candidate may provide broader, more durable responses than existing COVID-19 shots. Read More
Testing vaccine candidates with lab-grown organoids
Researchers have developed a new testing platform that encapsulates B cells -- important immune system components -- into miniature lab-grown organoids. The results, published Wednesday in ACS Central Science, may hasten vaccine screening and significantly reduce the number of experimental animals used in the process, the researchers said. Read More
COVID-19 vaccine development: Public funding yielded private profits
Decades before the COVID-19 pandemic, the U.S. government invested at least $337 million into critical research that led to mRNA COVID-19 vaccines. The government also paid $31.6 billion during the pandemic for vaccine research, production, and vaccines for all Americans. Read More
Vaccine effectiveness against Omicron variants may change over time
Researchers from The Chinese University of Hong Kong and the Harvard T.H. Chan School of Public Health in Boston, Massachusetts collaborated on a case-control study and found that two vaccines were generally effective over time against severe outcomes from SARS-CoV-2 Omicron infection. The research, published February 3 in the journal JAMA Network Open, also showed that protection among older individuals was more likely to wane six months after the second dose. Read More
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