Genomics
Prime editing creates desired gene mutations without collateral damage
A new gene editing tool called prime editing was demonstrated to efficiently create cell-specific knockout mice compared to traditional gene editing techniques. While both platforms successfully created mutations, prime editing did so without measurable on-target indels or off-targeting events, according to a study published in Genome Biology on March 16. Read More
Machine-learning system ranks most effective cancer drugs
Scientists successfully trained an ensemble of machine-learning (ML) algorithms to rank clinically relevant cancer drugs based on the drugs' predicted efficacy in reducing cancer cell growth. The study, reported in Nature Communications on March 25, suggests that ML may soon be widely used to predict the most appropriate treatment for individual patients with cancer. Read More
Scientists connect gene to cancer metastasis for the first time
Researchers have identified new functionality of a previously underappreciated gene, leucine-rich repeat neuronal 4 C-terminal like (LRRN4CL), which is overexpressed in melanoma cells. They believe LRRN4CL plays an important role in cancer metastasis to the lungs and describe their findings in Communications Biology on March 23. Read More
Scientists develop ultraspecific CAR T cells that kill only cancer cells
Scientists have devised a two-step engineering circuit that precisely targets solid tumors with chimeric antigen receptor (CAR) T cells. The engineering feat could be the next step in treating solid tumors using therapeutic T cells, a treatment that has remained out of reach for many cancer patients. The new method was detailed in a Science article on March 12. Read More
Gene therapy based on transcription factors could be effective against Alzheimer's
A type of gene therapy using transcription factors to target DNA has been shown to dramatically reduce levels of the harmful protein tau in preclinical mouse models of Alzheimer's disease. The findings, published in Science Advances on March 19, suggest that the therapy could easily translate to the clinic and be effective in humans. Read More
Scientists uncover secrets to controlling gene expression
Bioengineers have demonstrated that simultaneous control over transcription and translation in cells can achieve the most stringent control of gene expression to date. The findings, published in Nature Communications on March 19, will open new avenues for improved biotechnologies and synthetic biology applications. Read More
SARS-CoV-2 has changed very little since jumping from bats
The SARS-CoV-2 virus has required little to no significant adaptation to humans since its jump from bats in late 2019, according to a new study published in PLOS Biology on March 12. The evolutionary analysis of coronaviruses in bats and humans reveals that the infectivity of SARS-CoV-2 is derived from adaptation in bats, not humans. Read More
RNA editing affects gene expression -- with disease implications
Researchers found that RNA editing events can have large downstream effects that influence gene expression and subsequent phenotypic manifestations of that expression. RNA editing may be a previously underappreciated mechanism driving human diseases, according to an analysis published in Genome Biology on March 9. Read More
Can a single dose of a vaccine designed as 2 doses be effective?
Researchers suggested that two doses of a COVID-19 vaccine are more protective than a single dose, even if the interdose period is longer than recommended. The study's results, published in Science on March 9, indicate that the effect of vaccines on the spread and mutation of SARS-CoV-2 is reliant on relative robustness of immunity conferred by a single dose. Read More
Researchers extract new layer of data with proteomic analysis of cancers
Researchers have demonstrated the utility of proteomics in the analysis of seven aggressive cancers among a cohort of nearly 800 patient samples. The analysis, published in Oncogene on February 24, reveals potentially novel therapeutic targets. Read More
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter