An unprecedented view of gene regulation Massachusetts Institute of Technology (MIT) engineers have developed a technique to analyze the organization of the genome at a resolution 100 times higher than was previously possible.Read More
New STING-seq approach pinpoints disease-causing genetic variants Researchers are combining genome-wide association studies, CRISPR, and single-cell sequencing to discover causal variants and genetic mechanisms for blood cell traits. Their approach, dubbed STING-seq, published Thursday in Science, connects genetic variants to human traits and health, potentially helping to identify drug targets for genetic diseases.Read More
Getting to know the Association of Biomolecular Resource Facilities (ABRF) The Association of Biomolecular Resource Facilities (ABRF) will hold its Annual Meeting May 7 to May 10 in Boston. ABRF is a membership organization that brings together Core facilities across the U.S. and supports more than 2,400 members at over 400 institutions including organizations in government, academia, research, industry, and commercial settings. Over 50% of its members define their area of professional responsibility as either genomics or core administration.Read More
Gene variant map helps diagnose hereditary diabetes University of Copenhagen researchers are using high-throughput experiments to explore connections between inherited diseases and a specific gene called GCK. The study, published April 26 in Genome Biology, may help provide better diagnoses of hereditary diabetes and other diseases.Read More
Unique membrane protein stops viral infection in bacteria University of Rochester Medical Center (URMC) researchers revealed a previously unrecognized player in the CRISPR system: a membrane protein that enhances antiviral defense. The study, published Thursday in Science, broadens the current understanding of CRISPR’s complexities.Read More