Genomics Sponsored by Nvidia
Digital microfluidic technique connects cells to their environment
A new digital microfluidic technique allows researchers to connect physical cell properties with the molecular makeup of individual cells. This new approach, published in Nature Communications on November 11, will enable a deeper study of stem cells and other rare cell types for therapeutic development.  Discuss
Can vaccine resistance be predicted with test samples?
The likelihood of SARS-CoV-2 developing resistance to COVID-19 vaccines currently under development can be determined using repurposed blood and nasal test samples that are already being collected as part of clinical trials, according to Pennsylvania State University researchers. The perspective piece was published in PLOS Biology on November 9.  Discuss
Gene silencing target identified as possible leukemia treatment
Researchers have identified a molecule that permits growth of cancers such as leukemia by silencing certain host genes. The results, published in Nature Genetics on November 2, challenge the current understanding of epigenetic control during tumor development.  Discuss
Are SARS-CoV-2 mutations more contagious than the original virus?
The SARS-CoV-2 virus has accumulated genetic mutations that may make it more contagious and more easily spread in metropolitan communities, according to researchers who analyzed over 5,000 COVID-19 patient samples in the Houston area. They published their results in mBio on October 30.  Discuss
New COVID-19 immunogen could help with early diagnosis
A new assay that detects the unique SARS-CoV-2 orf8 protein in the sera of COVID-19 patients in the early stage of the infection is a strategic step in controlling the COVID-19 pandemic, according to research published online October 20 in mBio.  Discuss
New method reclaims resolution of single-cell RNA-seq
A new approach to RNA sequencing can enable scientists to extract 10 times more information from a single cell, including gene expression and subtle differences between healthy and diseased cells. The study, published in Immunity on October 13, reveals the power of the improved Seq-Well method and provides evidence of its efficacy in five inflammatory skin diseases.  Discuss
Novel nanoparticles deliver genetic therapy to bone marrow
Specialized nanoparticles can be used to deliver small interfering RNA to the bone marrow where they can turn off specific genes in bone-marrow endothelial cells to help treat heart disease or boost stem cell production, according to new research published in Nature Biomedical Research on October 5.  Discuss
Neanderthal heritage may be a risk factor for COVID-19
A new study shows that a genetic risk factor inherited from Neanderthal heritage is associated with two times greater risk of serious disease and death from COVID-19. The study was published in Nature on September 30.  Discuss
Science serves society, a crucial concept for gene therapy governance
With a focus on science and society, the American Society of Gene & Cell Therapy Policy Summit commenced on September 24. The ensuing discussion revealed how far science has advanced in a short period of time, and how the scientific community is rising to the challenge of gaining public buy-in for gene therapy.  Discuss
SARS-CoV-2 transcriptional patterns provide new insights into infection
New web resources provide insights into cellular genes that are impacted by coronavirus infection in the context of host molecular signaling pathways. These insights have the potential to speed novel drug development efforts in the fight against COVID-19, according to a new paper published in Scientific Data on September 22.  Discuss
Conferences
Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
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