AACR 2021: How machine learning and artificial intelligence are transforming cancer research
The use of digital tools has been incorporated into many areas of cancer research. However, experts agree that machine learning and artificial intelligence are poised to transform drug discovery efforts even further in the near future. Several scientists discussed case studies of how machine learning can be used in cancer biology and drug discovery efforts during the virtual American Association for Cancer Research (AACR) 2021 meeting. Read More
AACR 2021: Single-cell technologies bring new insights to tumor cells
Single-cell technologies have become important tools for cancer researchers and provide scientists with the ability to make measurements of individual cells to unveil heterogenicity among tissues. Recent developments in single-cell research have been a focus of the virtual American Association for Cancer Research (AACR) 2021 meeting held online April 9-14. Read More
A CRISPR on-off switch for genes controls expression without altering DNA
A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression. Read More
BioTools Innovator seeks to boost startups developing life science tools
BioTools Innovator is calling for applications to its inaugural competition to advance innovation by accelerating the growth of startups developing life science tools. Kathryn Zavala, PhD, managing director, recently discussed the program with Read More
NIH details progress of SCGE consortium
The U.S. National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) consortium has provided a detailed update, published in Nature on April 8, of projects to develop safer and more effective genome editing methods in somatic cells. Read More
Improved RNA sequencing method reveals new insights into small RNAs
Researchers have developed a new RNA sequencing method that can help discover many types of previously undetectable small RNAs. Details of the method, called panoramic RNA display by overcoming RNA modification aborted sequencing (PANDORA-seq), were published in Nature Cell Biology on April 5. Read More
X-ray crystallography identifies drugs to be repurposed for COVID-19
A new large-scale study indicates x-ray crystallography can be used to find drugs that could be repurposed to target the SARS-CoV-2 main protease. In addition to identifying 37 potential drug candidates, the study, published in Science on April 2, revealed a new binding site on the SARS-CoV-2 main protease to which drugs can bind. Read More
2nd-gen stem cell-derived CAR gene therapy is more durable, effective against HIV
A novel second-generation chimeric antigen receptor (CAR)-based approach targeting HIV infection using the genetic modification of hematopoietic stem cells shows promise in preclinical models. The details of the study were published in PLOS Pathogens on April 1. Read More
New gene therapy could be effective in treating complex polygenic conditions
Scientists are applying gene therapy approaches in a new way by simultaneously administering a combination of cargos to treat complex polygenic neurodegenerative diseases with no single genetic cause. Details of the combination gene therapy in two animal models were detailed in a March 31 Science Advances article. Read More
Cancer anti-inflammatory drug has potential to treat severe COVID-19
A new study provides evidence that an inexpensive clinical-grade inhibitor that's already approved to treat cancer, called topotecan, can be used to treat severe COVID-19, even in the late stages of the disease. The findings were published in Cell on March 30. Read More
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