Genomics
Cutting edge microscopy technique leads to new insights in cancer
New research published in the October 31 edition of Science debuts a new technique for creating high-resolution visual maps of the chromatin structure remodeling (RSC) complex to further understand its role in healthy and cancer cells. This research was led by Bradley Cairn, PhD, cancer researcher at Huntsman Cancer Institute and professor and chair of oncological sciences at the University of Utah.  Discuss
Orphan immunity gene clusters acquired for protection
Researchers from the University of Washington School of Medicine and Howard Hughes Institute found that gut bacteria acquire interbacterial defense gene clusters. The October 30 article in Nature, suggests that bacteria use these toxins against their microbial neighbors. This discovery could further scientific knowledge of the human gut which is critical to many aspects of health and disease.  Discuss
New insights into why tumor suppressor proteins go awry in cancer
Researchers from Stowers Institute for Medical Research in Kansas City, MO have identified proteins that are involved in tumor growth and metastasis in many cancers such as breast cancer. The research was published in Science Advances on October 23.  Discuss
Software improves the speed of identifying potential new antibiotics
Computational biologists at Carnegie Mellon University and seven other institutions developed a software tool that can play a high-speed "Match Game" to identify bioactive molecules and microbial genes that produce them so they can be evaluated as new antibiotics and other therapeutic agents. This work was published in Cell Systems on October 16.  Discuss
Scientists elucidate the genetic impact of host immune system on the microbiome
Researchers at the University of Chicago conducted research that suggests that the genetic differences in the immune system contribute to bacterial colonization of gut. The findings, published in Cell Reports on October 15, uses a new approach to determine the genetic influence of the immune system on the microbiome of mice.  Discuss
New CRISPR Cas13 system offers powerful antiviral protection
A first-of-its-kind study conducted by researchers at the Broad Institute of MIT and Harvard demonstrates that Cas13, a class 2 CRISPR system, can be used as an antiviral in cultured human cells. The research, published in Molecular Cell on October 10, suggests that the RNA-cutting enzyme can be programmed to detect and destroy RNA-based viruses.  Discuss
DNA Metabarcoding used to analyze human diet
A collaborative study from US researchers demonstrates that DNA metabarcoding has promise for characterization of human diets. The research, which was published in mSystems on October 8, provides evidence that DNA sequencing-based approaches can be successfully applied to human samples.  Discuss
Driven by nanotech and other micro technologies electron microscopy market continues to grow
According to a new report from Strategic Directions International (SDI), the total market for electron microscopy instrumentation was in excess of $2.5 billion in 2018 and is expected to reach nearly $3.4 billion by 2023.  Discuss
Forward-oriented gene therapy improves treatment for sickle cell disease
Researchers at the National Institutes of Health (NIH) have developed a new and improved viral vector that is up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than conventional treatments. The work was published in Nature Communications on October 2, and was supported by the National Heart Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH.  Discuss
Personalized cancer vaccines now possible due to discovery of cancer frameshift neoantigens
Researchers from Arizona State University's Biodesign Institute demonstrated experimental proof-of-concept that cancer mutations produce individual neoantigens, or newly formed antigens, and can be used for cancer vaccines. The new paper published in Scientific Reports on October 2, shows that neoantigens can be used to protect against cancer.  Discuss
Conferences
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
Medlab Middle East
February 3-6, 2020
Dubai, Dubai United Arab Emirates
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