Genomics
Scientists create atlas of mouse brain regions down to single cells
An atlas of the mouse cerebrum and primary motor cortex down to the level of single cells was published in a pair of papers on October 6 in Nature. The research reveals the mammalian brain's organization at an unprecedented level of detail and sheds new light on gene regulatory factors, promising to inform future work on developing targeted therapies for human diseases. Read More
Learning from older drug modalities accelerates viral process development
Andrew Tustian, EngD, director of viral process development at Regeneron Pharmaceuticals, spoke with ScienceBoard.net about accelerating process development for adeno-associated viruses by modifying strategies from older modalities. Read More
New 4D visualization shows epigenetic processes unfold over time
Scientists have developed a new visualization method to construct 4D models of X chromosome inactivation, lending insight into gene expression and opening new pathways to drug treatments for gene-based disorders and diseases. The findings are being published on October 8 in the Proceedings of the National Academy of Sciences of the United States of America. Read More
Cancer Cell Map Initiative reveals protein interactions that drive cancer
A research group has mapped previously unknown interactions between proteins that drive cancer, thereby revealing potential new biomarkers and drug targets. The findings were published in a trio of papers in Science on October 1. Read More
Halo Labs releases gene therapy quality analysis instrument
Halo Labs has launched Aura GT, a next-generation instrument that can correlate capsid aggregation with DNA leakage or empty and full capsids. Read More
Nanoscale sequencer detects 2 cancer-linked RNA base modifications simultaneously
Using a new nanoscale sequencer, a research group has sequenced a microRNA that is a marker for refractory gastrointestinal cancer. The novel method can detect two types of chemical base modifications simultaneously, according to a study published on September 29 in Scientific Reports. Read More
New tools are needed for next-gen gene therapies
BOSTON - Delivering next-generation viral vectors for use in gene therapies requires that scientists reenvision the tools and process modalities that could be leveraged to make gene therapy a reality, according to Stefano Menegatti, PhD, associate professor at North Carolina State University. Menegatti spoke with ScienceBoard.net during the BioProcess International conference in Boston. Read More
Nanopore sensor quickly detects infectious viruses
Scientists have designed a nanopore-based sensor that can detect the presence and infectiousness of a virus in a sample within minutes, according to a new study published in Science Advances on September 22. The new method successfully detected SARS-CoV-2, positioning it as a speedier, less fussy alternative to other tests. Read More
Biotech Week Boston highlights research progress in cell and gene therapy
At Biotech Week Boston, ScienceBoard.net Editor-in-Chief Samantha Black, PhD, spoke with experts in cell and gene therapy technologies. Read More
Cancer-linked genes help tumors evade immune system
Tumors have more genetic tricks for escaping detection by the immune system than previously thought, according to a new study published on September 17 in Science. The study results may inform the development of therapeutic strategies that can counter those tricks. Read More
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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