Genomics Sponsored by Nvidia
Gene silencing target identified as possible leukemia treatment
Researchers have identified a molecule that permits growth of cancers such as leukemia by silencing certain host genes. The results, published in Nature Genetics on November 2, challenge the current understanding of epigenetic control during tumor development.  Discuss
Are SARS-CoV-2 mutations more contagious than the original virus?
The SARS-CoV-2 virus has accumulated genetic mutations that may make it more contagious and more easily spread in metropolitan communities, according to researchers who analyzed over 5,000 COVID-19 patient samples in the Houston area. They published their results in mBio on October 30.  Discuss
Deep-learning approach easily identifies druggable protein sites
A deep-learning algorithm was able to automatically identify binding sites on proteins that could be good targets for drug candidates, according to research published October 27 in Communications Biology. The algorithm, called Binding Site Neural Network (BiteNet), could help researchers sort through the almost 20,000 proteins in the human genome to find the ones that are most promising.  Discuss
New COVID-19 immunogen could help with early diagnosis
A new assay that detects the unique SARS-CoV-2 orf8 protein in the sera of COVID-19 patients in the early stage of the infection is a strategic step in controlling the COVID-19 pandemic, according to research published online October 20 in mBio.  Discuss
Patient-specific airway stem cells developed to model lung diseases
Researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells. These cells can be used to study acquired and genetic airway diseases, according to an article published in Cell Stem Cell on October 23.  Discuss
Researchers identify 'ancient' DNA weapons against cancer
Researchers have identified silent ancient DNA elements buried in the human genome that when "reactivated" can initiate an immune response toward cancer cells. They also identified a key enzyme, normally used by cancer cells to evade immune responses, that can be leveraged against them. The research was published in Nature on October 21.  Discuss
A 'Pac-Man' like CRISPR system could enable larger gene edits
A new CRISPR tool utilizes Cas3 to remove larger than normal stretches of DNA both quickly and accurately. The tool, described in an October 19 article in Nature Methods, could help fill a void in current gene editing capabilities.  Discuss
New methods could improve AAV quality for viral vector manufacturing
Developing well-characterized adeno-associated viral vectors (AAVs) is a significant obstacle for the biomanufacturing industry. A group of analytical researchers is trying to overcome this challenge by developing novel analytical methodology specifically designed for AAVs.  Discuss
New method reclaims resolution of single-cell RNA-seq
A new approach to RNA sequencing can enable scientists to extract 10 times more information from a single cell, including gene expression and subtle differences between healthy and diseased cells. The study, published in Immunity on October 13, reveals the power of the improved Seq-Well method and provides evidence of its efficacy in five inflammatory skin diseases.  Discuss
EpiMorgify algorithm predicts best conditions for cell therapies
In order to determine optimal cell growth conditions for the development of cellular therapies, researchers have devised an algorithm called EpiMorgify that can predict what factors are needed to produce high-quality cultures. The study was published on October 9 in Cell Systems.  Discuss
Conferences
Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
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