Genomics
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22.  Discuss
Yeast metabolism may offer lessons on starving cancer cells
Scientists may have found a new way to starve cancer cells by learning from growth regulation mechanisms employed by yeast. They found that the same metabolic mechanism used by yeast to respond to nutrient shortages is also employed by mammalian cells -- a finding that could lead to new cancer therapies, according to a new study published in Nature Metabolism on January 20.  Discuss
Researchers work out the early steps that drive malignancy
Researchers from Yale University have identified cellular characteristics that lead to the early stages of malignancy. They state that in at least one form of blood cancer, cells with cancer-causing lesions can remain normal until cell division speeds up the process. The results were published in Nature Communications on December 18.  Discuss
Algorithm provides new insight into hierarchical DNA structures that influence disease
Researchers develop an algorithm that locates specific topologically associating domains (TADs) which are implicated in disease development, including cancer. The technology, called OnTAD, can examine internal architectures of TADs, which are important in elucidating their biological functions. The work was published in Genome Biology on December 18.  Discuss
Researchers explore the role of circular DNA in deadly childhood cancer
Researchers from Charité - University Medicine Berlin and the Memorial Sloan Kettering Cancer Center in New York combine genomic and transcriptomic approaches to describe the landscape of extrachromosomal circular DNA in neuroblastoma. The work was published in Nature Genetics on December 16.  Discuss
Leveraging new technologies to push the boundaries of our knowledge of cell biology
At the American Society of Cell Biology, European Molecular Biology Organization Joint Meeting in Washington, DC from December 7-11, emerging topics and new technologies were discussed and highlighted. Proteomics and genomics seemed to be a focus of the meeting. Many researchers presented novel ideas to incorporate new technologies in these fields to make discoveries in cell biology.
New method reveals 3D DNA structure
The scientist who developed a new method of illuminating 3D genomic structures, called Dip-C, is awarded the SciLifeLab Prize for Young Scientists by the Science for Life Laboratory in Sweden and the journal Science. The research of the grand prize winner, Longzhi Tan, builds on the work of the Human Genome Project by developing an algorithm to capture diploid chromosome conformation.  Discuss
New molecular drivers of Parkinson's disease identified
A group of researchers at the Icahn School of Medicine at Mount Sinai have discovered new molecular drivers of Parkinson's disease (PD) and subsequently determined how they impact the function of genes involved in the disease. This was accomplished using a complex statistical technique called multiscale gene network analysis (MGNA). The results were published in Nature Communications on November 20.  Discuss
Genomic breakthrough in malaria research
An international consortium of researchers from the Institute of Cell Biology at the University of Bern and Umeå University in Sweden conducted a genome-wide deletion study to determine genes that are required for malaria parasite transmission. The results were presented in Cell on November 14.  Discuss
Modified CRISPR system aims to improve therapies for HIV, sickle cell disease
Researchers from City of Hope have improved the CRISPR-Cas9 system through novel sequence changes to the trans-activating RNA (tracrRNA). The improved tool could help to fast track new therapies for HIV, sickle cell disease and other immune conditions. The results were published in Scientific Reports on November 6.  Discuss
Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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