Immunology
Oncolytic virotherapy, immunotherapy combo shows promise for treatment-resistant cancers
A combination of oncolytic virotherapy, a technique using cancer-fighting viruses, acting in concert with immunotherapy shows promise for treatment-resistant cancers, according to new research. Read More
Localized delivery of IL-2 by drug-producing cells eradicates cancer in mice
Implanting beads loaded with cytokine-producing cells eradicates advanced-stage mesothelioma tumors in mice, according to a study published on August 22 in Clinical Cancer Research. Read More
First full map of immune system connections unlocks drug discovery opportunities
Researchers have created the first full map of immune system connections showing how immune cells communicate, pointing to ways to modulate the pathways to treat cancer and infectious diseases. Read More
Researchers identify T cells that protect against ischemic stroke in mice
University of Pittsburgh neurologists and immunologists have identified a subset of CD8+ regulatory-like T cells (CD8+TRLs) that provide fast-acting and lasting protection against ischemic stroke in mice, offering a potentially novel immunotherapy for stroke in humans. Read More
3D imaging reveals picture of T-cell activity to unlock solid tumor opportunity
Researchers have used imaging and transcriptomics to identify T cells with potent serial killing capacity in a push to expand use of the immunotherapies to solid tumors. Read More
Single-cell analyses shed light on drug resistance of melanoma brain metastases
Using single-cell genetic analyses of frozen brain samples, Columbia University researchers have uncovered evidence of how melanoma brain metastases evade current treatments. Read More
Machine learning model opens door to real-time detection of cell therapy contamination
Researchers at the Massachusetts Institute of Technology’s Singapore site have developed a new way to detect adventitious microbial contamination in mesenchymal stromal cell cultures. By using machine learning to predict if a culture is contaminated in near real-time, the approach could enable testing to take place during the production of cell therapy products. Read More
Manufacturing partnerships support high quality cell therapies
Chimeric Therapeutics, Ncardia, and Novartis are some of the companies that have decided to partner to make complex manufacturing processes more efficient for novel therapies, according to Cell and Gene Therapy Business Outlook, a sister publication of ScienceBoard. Read More
MASTER technology could transform CAR T-cell therapy
A new technology that helps CAR T cells attack cancer cells more aggressively than conventional methods has been published by researchers from North Carolina. Called multifunctional alginate scaffold for T-cell engineering and release (MASTER), the technology was described in a paper published on March 24 in Nature Biotechnology. Read More
NKILT moves from stealth mode to active fundraising
ScienceBoard.net recently caught up with NKILT Therapeutics leaders Raphael Ognar and Henri Bayle at the 2022 American Association for Cancer Research Annual Meeting in New Orleans. Read More
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