Drug Discovery & Development
Validating drug repurposing workflows may help identify new COVID-19 treatments
A research team has strengthened COVID-19 drug repurposing workflows through independent in vitro validation followed by clinical pharmacology data assessments, with the goal of launching clinical studies of currently approved drugs. The protocol was published in ACS Pharmacology & Translational Science on October 14.  Discuss
Can SARS-CoV antibodies be used to develop universal coronavirus vaccines?
Can antibodies developed against SARS-CoV during the 2003 outbreak be used to prevent infection by SARS-CoV-2? In an October 9 study published in Science Advances, researchers analyzed precious serum collected from convalescent SARS-CoV patients to find out.  Discuss
Will mutation of the SARS-CoV-2 virus affect vaccine effectiveness?
What impact will mutation of the SARS-CoV-2 virus have on the effectiveness of COVID-19 vaccines that are in development? In a new study published in NPJ Vaccines on October 8, Australian researchers say they believe that a recent change in the genetic material of the virus shouldn't reduce the effectiveness of vaccines coming to market.  Discuss
FDA issues guidance on submitting EUA requests for COVID-19 vaccines
The U.S. Food and Drug Administration (FDA) on October 6 issued a new guidance with recommendations for developers of COVID-19 vaccines regarding the scientific data and information that would be required to support emergency use authorization (EUA) for the products.  Discuss
Novel nanoparticles deliver genetic therapy to bone marrow
Specialized nanoparticles can be used to deliver small interfering RNA to the bone marrow where they can turn off specific genes in bone-marrow endothelial cells to help treat heart disease or boost stem cell production, according to new research published in Nature Biomedical Research on October 5.  Discuss
Flood of COVID-19 papers allows substandard research to slip through
This year's deluge of COVID-19 research publications has allowed substandard research to be published by academic journals or to be housed on preprint servers, resulting in the retraction of some papers. The chaotic publishing environment has potentially harmful implications for COVID-19 patients during treatment, a leading bioethicist wrote in a brief published in the Journal of Medical Ethics on October 1.  Discuss
RNA targeting could prevent replication of SARS-CoV-2 virus
What if you could stop the SARS-CoV-2 virus from reproducing itself? Researchers from Florida hope to do just that by creating a compound that targets and binds to RNA regions on the SARS-CoV-2 genome and disrupts its replication. The research was described in a September 30 article published in ACS Central Science.  Discuss
Science and scientists held in high esteem across the globe
An international survey conducted by the Pew Research Center found that scientists and their research are widely viewed in a positive light across global publics and many believe that government investments in research benefit society.  Discuss
Passive vaccines with mAbs may be effective for COVID-19
Monoclonal antibodies (mAbs) isolated from the blood of recovered COVID-19 patients -- known colloquially as "convalescent plasma" -- could be potentially useful as therapeutic and prophylactic agents for passive vaccination, assuming their administration does not trigger unwanted side effects. The findings of the new study were published in Cell on September 26.  Discuss
Is 'bespoke' therapy the future of genomic medicine?
Gene therapies hold extremely exciting promise for meeting the unmet needs of many individuals with genetic diseases, as discussed in a session of the second annual American Society of Gene & Cell Therapy Policy Summit on September 24.  Discuss
Conferences
Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
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