Drug Discovery & Development
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
New research helps scientists understand the genetic cause of immune disease
Research published in Nature Genetics on September 23 helps narrow down the search for molecular drivers for immune disease which could result in the identification of new drug targets and development of new therapies illnesses such as asthma, multiple sclerosis, and arthritis.  Discuss
Novel "death star" nanoparticle discovered for potential use in targeted therapies
A novel nanoparticle has been reported by researchers at San Diego State University with the potential to serve as a delivery system for therapeutics. The research published on September 17 in eLife describes how Metamorphosis Associated Contractile structures (MACs) trigger metamorphosis in tubeworms. Moreover, they identify a novel protein (with syringe-like structures, nicknamed Death Star for the effect it has) responsible for the activation of metamorphosis.  Discuss
Repurposed drug shows potential to slow neurodegeneration in Parkinson's disease patients
Collaborative research from the University of Iowa and researchers in China and Spain, show evidence that a current drug used to treat prostate cancer may improve Parkinson's disease (PD) symptoms by slow neurodegeneration. The results from experimental models and clinical database analysis were published on September 16, in the Journal of Clinical Investigation.  Discuss
Is nanomedicine a feasible option for the pharmaceutical industry? – from the 4th Peptide Drug Design & Delivery Summit
The use of nanoparticles in the pharmaceutical industry is a topic of hot debate among scientists. At the 4th Annual Peptide Drug Design and Delivery Summit, August 27 -29 in Philadelphia, PA, researchers discussed the merits and challenges of incorporating these molecules into therapies.  Discuss
Germline genetic testing in breast cancer patients may lead to increased therapy options
Genetic testing for metastatic breast cancer patients may play a key role in identifying additional patients with increased risk and their response to targeted therapies.  Discuss
Breakthrough electrochemical technique may bring cost savings to drug companies
Researchers have developed a simple new method for the creation of hindered ether compounds, which are often important components of many drugs and commercial products. Hindered ethers have been traditionally difficult to manufacture, but scientists at Scripps Research have published a new electrochemistry technique in Nature on September 9, which allows these compounds to be produced faster and more efficiently.  Discuss
The drug development industry is hungry for 3D printing – from the 4th Peptide Drug Design & Delivery Summit
The Science Advisory Board attended the 4th Annual Peptide Drug Design and Delivery Summit in Philadelphia from August 27 to 29. One of the most discussed topics at the event of the use of 3D printing for pharmaceutical applications. Many scientists are pursuing this technology with gusto, utilizing the technology to improve peptide drug design.
Vaccine in development against hypervirulent Klebsiella
Concerns arising over the development of hypervirulent strains of Klebsiella pneumoniae have led researchers to develop an entirely new vaccine to protect against the gram-negative bacteria. A team of researchers at Washington University School of Medicine in St. Louis and VaxNewMo (a startup based in St. Louis) designed the vaccine by genetically manipulating E. coli. The details of the prototype designed were published in the Proceedings of the National Academy of Sciences on August 27th.  Discuss
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th.  Discuss
Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
Medlab Middle East
February 3-6, 2020
Dubai, Dubai United Arab Emirates
Japan Analytical & Scientific Instruments Show (JASIS)
November 11-13, 2020
Chiba, Chiba Japan
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