Drug Discovery & Development
Artificial intelligence helps researchers find new antibiotics
To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find new potential antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing.  Discuss
Breakthrough in coronavirus research provides map for vaccines
Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Communication of cancer cells analyzed with organoids and novel cytometry
A new technique using organoids, self-organizing 3D tissue models, can decipher how individual cancer cells communicate with each other and the unique signals they create. This research, published in Nature Methods on February 17, could be used to help develop personalized cancer treatments in the future.  Discuss
Experts map the future of bioprinting
Bioprinting has rapidly advanced in both techniques and clinical applications, but key challenges still remain for the burgeoning field. A multinational team of researchers offered their recommendations for how to address these hurdles in an in-depth road map article published February 7 in Biofabrication.  Discuss
Hydrogels enable on-demand production of pharmaceuticals
A first-in-class system that effectively embeds engineered microbes into the solid support of a 3D-printed hydrogel is described in a report published in Nature Communications on February 4. The hydrogel system organizes both individual microbes and groups of microbes for on-demand production of pharmaceuticals.  Discuss
Math models improve the effectiveness of immunotherapy
Scientists working at the intersection of math and medicine propose new strategies based on mathematical modeling and known molecular mechanisms to improve the efficacy of lifesaving immunotherapies for cancerous tumors. The work was published on February 3 in the Proceedings of the National Academy of Sciences.  Discuss
Nanoparticles eat cardiovascular plaques from the inside out
Scientists have engineered a nanoparticle that eats plaques associated with cardiovascular disease -- from the inside out. This Trojan horse technology could offer a new therapeutic option for the treatment of atherosclerosis, according to a study published in Nature Nanotechnology on January 27.  Discuss
Stem cell findings help researchers learn about early-onset Parkinson's
New research utilizing stem cells indicates that the metabolic processes that lead to young-onset Parkinson's disease could begin years before symptoms of the disease emerge. But the findings also point to a potential drug candidate that could be used to treat the condition, according to a study published January 27 in Nature Medicine.  Discuss
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22.  Discuss
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration.  Discuss
Conferences
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International Europe
July 13-16
Amsterdam, Noord-Holland Netherlands
Bioprocess International West
August 10-13
Santa Clara, California United States
BioProcess International
September 21-24
Boston, Massachusetts United States
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