Drug Discovery & Development
New 'armed' CAR T cells can locally activate small-molecule cancer drugs
A new engineered CAR T platform, which turns cells into targeted “micropharmacies” with local activation of small-molecule prodrugs, has been shown to exhibit enhanced antitumor activity and can overcome a variety of current obstacles in conventional CAR T-cell therapy. The research, conducted by Memorial Sloan Kettering Cancer Center scientists, was published in Nature Chemical Biology on December 30, 2021. Read More
Gene therapy research collaborations gain traction for next-gen medicines
Research collaborations are becoming increasingly more common, allowing companies to pool existing resources to advance innovations in the field of medicine. There are many partnerships within the gene therapy field, according to Cell and Gene Therapy Business Outlook, a sister publication of ScienceBoard. Some companies engaging in such research collaborations are Regeneron, EdiGene, and Ferring Ventures. Read More
Top 10 ScienceBoard stories of 2021
It's been a very busy year for scientists and biotech/biomedical professionals. From COVID-19 vaccines to innovations in cell and gene therapies, the field is growing at an unprecedented pace -- with no end in sight. In 2021, ScienceBoard strived to keep our readers updated on the latest news and research in the biopharmaceutical and life sciences fields, along with insights into the people and the innovations behind notable developments. Read More
FDA authorizes Pfizer's COVID-19 pill
The U.S. Food and Drug Administration (FDA) has issued an emergency use authorization for nirmatrelvir and ritonavir tablets (which are co-packaged for oral use and sold under the brand name Paxlovid) for the treatment of mild to moderate COVID-19 in adults and pediatric patients (age 12 and older) who have tested positive for SARS-CoV-2 and who are at high risk of developing severe COVID-19, including hospitalization or death. Read More
Seqster pursues mission to bring patients to center of healthcare
Patient access to data is a critical mission for the healthcare industry, according to Ardy Arianpour, CEO and co-founder of Seqster, who recently spoke with ScienceBoard Editor in Chief, Samantha Black, PhD. The company is focused on developing much-needed data interoperability tools for the healthcare sector. Read More
EpiCypher secures co-licensing agreement for foundational chromatin technology
EpiCypher has co-exclusively licensed cleavage under targets and release using nuclease and cleavage under targets and tagmentation technology from the Fred Hutchinson Cancer Research Center. The agreement strengthens EpiCypher's intellectual property to include both research-use-only and diagnostic applications. Read More
New gene writing tech shows promise for large DNA insertions
An international team has developed a new gene writing technology called find cut-and-transfer that is able to make large gene insertions. The approach, published in Nature Communications on December 3, has potential gene editing and gene therapy clinical applications in patients with genetic and oncological diseases who have few treatment options. Read More
Roche automates next-gen sequencing sample prep
Roche announced the launch of the Avenio Edge System, a core component of Roche's strategy to advance sequencing technologies. The system is built on Roche's foundational capabilities to deliver a fully automated, integrated sequencing solution. Read More
COVID-19-related sales remain strong for lab tool firms in 2021
Laboratory tool companies have been among the biggest beneficiaries of U.S. government COVID-19-related spending on coronavirus testing and vaccine R&D and manufacturing. COVID-19-related sales have propelled sales at Thermo Fisher Scientific, Danaher, and PerkinElmer, already three of the world's largest scientific instrument and reagent providers. Read More
New 'antibody-decorated nanocrystals' target cancer cells
Researchers have bioengineered a metal-organic framework antibody drug delivery system that has the potential to fast-track personalized therapies for cancer and other diseases. The findings were published December 7 in the journal Advanced Materials. Read More
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