Drug Discovery & Development
New platform includes biological similarities to accelerate drug discovery
A new open-access tool provides information on the effects of nearly 1 million compounds in a wide range of biological settings. The new tool, published in Nature Biotechnology on May 18, may change the drug discovery process by moving beyond reliance on chemical information alone.  Discuss
U.S. launches project to promote pharma manufacturing
The U.S. Department of Health and Human Services on May 19 announced a new project to promote U.S.-based pharmaceutical manufacturing to secure the supply of essential medicines during crises like the COVID-19 pandemic. The project includes a $354 million contract with Phlow of Richmond, VA.  Discuss
Human enzymes are implicated in SARS-CoV-2 evolution and spread
Two human deaminase enzymes that edit viral RNA inside cells could have implications for the evolution of SARS-CoV-2 and the spread of the infection, according to a study published in Science Advances on May 18.  Discuss
SARS-CoV mAb shown to block SARS-CoV-2
Antibodies from recovered SARS-CoV patients appear to block SARS-CoV-2 infectivity and could help in the development of antiviral treatments or vaccines, according to a new study. The findings were published in Nature on May 18.  Discuss
Proteomics provides insights into SARS-CoV-2 infection, potential therapies
Scientists tested a series of compounds for blocking the replication of SARS-CoV-2 using a novel proteomics approach. The method, which helped identify small-molecule drugs that may be effective at treating COVID-19 patients, was published in Nature on May 14.  Discuss
Researchers explore role of cytokine storm in severe COVID-19
An overreaction of the immune system to SARS-CoV-2 -- a phenomenon known as cytokine storm -- has emerged as a major contributor to patient mortality during the COVID-19 outbreak. In a recent series of papers, authors examined cytokine storm and offered perspectives on preventing it from occurring.  Discuss
Moving closer to orally dosed peptide medications
A new method can identify among billions of double-bridge peptides the ones that are most likely to bind to disease targets of interest and escape enzymatic degradation in the gastrointestinal tract. A study on the method was published in Nature Biomedical Engineering on May 11.  Discuss
NIH leadership discusses COVID-19 vaccine collaborations
Public-private partnerships could help meet the unprecedented need to manufacture and distribute safe and effective COVID-19 vaccines around the globe, according to leaders from the U.S. National Institutes of Health (NIH) and the Fred Hutchinson Cancer Research Center. They discussed how in Science on May 11.  Discuss
Researchers call for rapid drug repurposing to fight COVID-19
Filling the therapeutic gap for coronavirus treatments with existing drugs approved for other uses could greatly benefit patients around the world. Researchers from the University of Kentucky urged the scientific community to quickly identify drugs that may be repurposed in the fight against COVID-19 in an opinion piece published May 8 in Science.  Discuss
Genomic tools help researchers understand how SARS-CoV-2 is evolving
A new study has identified nearly 200 recurrent genetic mutations in the SARS-CoV-2 virus, according to research published as a preproof in Infection, Genetics and Evolution on May 5. The findings could offer clues to how the virus is adapting and evolving in humans and lead to optimal drug and vaccine targets.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
General Discussion
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