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Clinical investigators need to be wary of confounding and bias in real-world studies; here is what to look for and how to address it
Clinical investigators use real-world data (RWD) in randomized trials and observational studies to produce real-world evidence (RWE) used to assess the safety and efficacy of an intervention and to inform product development, regulatory approval, and post-market surveillance efforts.
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity.
Simpler, cheaper screening method developed to democratize COVID-19 drug discovery
An alternative method for finding single-chain antibodies has yielded COVID-19 drug candidates that may be effective against variants of concern.
Enzyme-activated drug candidate points to new way to treat liver cancer
Small molecules that are activated by an enzyme produced by some tumors could improve the treatment of liver cancer, a study run by scientists at the National Institutes of Health (NIH) and Massachusetts General Hospital suggests.
GHIT Fund provides $1.9M for malaria drug development
The Global Health Innovative Technology (GHIT) Fund on Monday announced approximately $1.9 million (260 million yen) in funding for the research and development of a new malaria drug.
Pfizer to acquire Seagen for $43 billion
Pfizer will acquire Seagen, a firm specializing in the discovery and development of treatments for cancer, the firms announced on Monday.
Nasal antibody modulates inflammatory response in COVID-19 patients in small clinical trial
A nasally administered monoclonal antibody modulated inflammatory responses in COVID-19 patients in a small clinical trial.
Light-controlled drug delivery platform opens opportunities to treat pain, cancer
A self-powered, light-controlled drug delivery platform could enable the controlled release of medicines and eliminate the need to surgically extract the implant after use, according to research published in the
Proceedings of the National Academy of Sciences (PNAS)
Immune homing mechanism enables targeted drug delivery to pediatric brain tumors in mice
Piggybacking on the homing mechanism that the immune system uses to direct white blood cells could enable the targeted delivery of drugs in children with brain tumors, according to research published on Thursday in
COVID-19 vaccine development: Public funding yielded private profits
Decades before the COVID-19 pandemic, the U.S. government invested at least $337 million into critical research that led to mRNA COVID-19 vaccines. The government also paid $31.6 billion during the pandemic for vaccine research, production, and vaccines for all Americans.
More Conferences »»
Mayo Clinic Laboratories, Helix collaborate to provide suite of laboratory services to biopharma customers
Berkeley Lights launches optofluidic system
Protillion Biosciences raises $18M in financing to support therapeutic biomarker discovery
MinervaX announces funding for Group B Streptococcus vaccine
Vegetables contain ‘garden variety’ cancer drugs
More articles »
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