Drug Discovery & Development
Analysis of COVID-19 literature identifies possible knowledge gaps
An analysis of COVID-19 scientific abstracts using natural language processing and machine-learning techniques suggests that the literature currently lacks basic research on the pathogenesis and viral transmission of SARS-CoV-2, according to a September 16 article published in Patterns.  Discuss
New approach to cancer immunotherapies combines 2 mAb treatments
A new approach to increasing the effectiveness of current cancer immunotherapies combines existing therapies with new monoclonal antibodies (mAb) that block inhibitory cytokines in tumor microenvironments, allowing the body to effectively eliminate tumors. The results of the study were published in Nature Communications on September 11.  Discuss
Customized gene therapies successfully target rare eye diseases
Can gene therapies prove effective for the treatment of rare genetic diseases? One company may have found a solution that incorporates a high degree of customization, manufacturing expertise, and years' worth of knowledge.  Discuss
Study investigates pharmacogenomics of COVID-19 therapies
Human genetic variation may alter the interactions of drugs being used to treat patients with COVID-19 symptoms, resulting in a range of clinical responses -- from no effect to high toxicity in some patients, according to a study published in Nature Genomic Medicine on August 18.  Discuss
Will a COVID-19 vaccine really let us go 'back to normal'?
Will the arrival of a COVID-19 vaccine be enough to allow society to go "back to normal" in the near future? The answer to that question depends on a wide range of variables, such as how effective the vaccine is and how many people get vaccinated, according to an article published in the American Journal of Preventive Medicine on August 25.  Discuss
Pharmacists issue guidance for mass COVID-19 vaccination
As society prepares for the rollout of COVID-19 vaccines, the American Society of Health-System Pharmacists has issued 10 guiding principles for development, distribution, allocation, and oversight of vaccines. The guidelines build on the organization's research and best practices expertise in pandemic preparedness, supply chain management, distribution, and clinical practice.  Discuss
ESMO recommends use of NGS for advanced cancers
The European Society for Medical Oncology (ESMO) released its first recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers. The guidance was published in the Annals of Oncology on August 25.  Discuss
Data-sharing platform could help planning for future pandemics
In response to the global pandemic, the authors of a new paper are calling for a robust centralized platform to improve international data sharing among scientists and policymakers. The article was published on August 19 in the journal Science & Diplomacy.  Discuss
Microbe-based platform aims for sweet spot between biologics and gene therapy
A microbe-based therapeutics platform that has been in development for nearly 30 years is gaining traction for the treatment of inflammatory and autoimmune diseases. The company that is developing the platform, Precigen ActoBio, is advancing a lead candidate through clinical trials with the long-term goal of finding a sweet spot between biologics and gene therapies.  Discuss
Early trials show potential of Pfizer COVID-19 vaccine
Pharmaceutical giant Pfizer is making progress on BNT162b1, a COVID-19 vaccine candidate that is undergoing development and for which the U.S. government has secured access to 300 million doses in 2021. The results of the phase I/II clinical trials were published in Nature on August 12.  Discuss
Conferences
ESMO Virtual Congress 2020
September 14-29
Online
BioProcess International West
September 21-25
Online
BioProcess International
September 21-25
Online
ASGCT 2020 Policy Summit
September 23-25
Online
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