Drug Discovery & Development
Scientists in the Lab: Featuring Rajan Chaudhari
We are thrilled to introduce our next laboratory scientist this month, who works at the intersection of chemistry, drug development, and data science. Rajan Chaudhari, PhD, is a postdoctoral fellow at the University of Texas MD Anderson Cancer Center in Houston.  Discuss
Nanoparticles direct 'suicide genes' to treat brain tumors in children
Researchers from Johns Hopkins University report a bioengineered nanoparticle that successfully delivers a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. Details of the nanoparticle treatment were published in the January 2020 edition of Nanomedicine: Nanotechnology, Biology and Medicine.  Discuss
New drug target identified in malaria transmission
Australian researchers from the University of Melborne and Griffith University in Queensland have confirmed their findings of a new drug target that blocks the transmission of Plasmodium falciparum in mosquitos. The results were published in Cell Reports on December 17.  Discuss
Adenosine bandages improve tissue repair
Researchers at Duke University have engineered a bandage that captures and holds a pro-healing molecule at the site of a bone break to accelerate and improve the natural healing process. The proof-of-concept experiment was conducted in mice, and the results were published on December 12, in Advanced Materials.  Discuss
New nanoparticles help reduce inflammatory disease
Researchers from Washington State University have discovered a potential new treatment option for diseases associated with inflammation. The study, published in Science Advances on November 6, describes a new patent-pending nanotechnology that specifically targets activated neutrophils that compromise the immune system.  Discuss
Liver-Chip can now determine human-specific toxicities
A group of academic and industry researchers developed new Liver-Chips with four cell types found in the livers of rats, dogs, and humans. The idea was generated at Wyss Institute for Biologically Inspired Engineering at Harvard and then transferred to Emulate Inc., to provide real-time analysis of complex biochemical interactions and enhanced liver toxicity testing.  Discuss
Personalized cancer vaccines now possible due to discovery of cancer frameshift neoantigens
Researchers from Arizona State University's Biodesign Institute demonstrated experimental proof-of-concept that cancer mutations produce individual neoantigens, or newly formed antigens, and can be used for cancer vaccines. The new paper published in Scientific Reports on October 2, shows that neoantigens can be used to protect against cancer.  Discuss
The Parkinson’s Foundation launches large-scale genetic study, aiming to improve patient care and speed clinical trials
More than 10 million people worldwide are currently living with Parkinson’s disease (PD), a neurodegenerative disorder that impacts the dopamine-producing neurons in the brain. Scientists do not know exactly what causes PD, but they believe it is a combination of genetic and environmental factors. Nearly 10% to 15% of all PD cases are caused by genetic mutations. A new study aims to understand how the disease develops and how it can be treated or cured. This study, PD GENEration: Mapping the Future of Parkinson’s Disease is currently being conducted by the Parkinson’s Foundation.  Discuss
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Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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