Drug Discovery & Development
Is 'bespoke' therapy the future of genomic medicine?
Gene therapies hold extremely exciting promise for meeting the unmet needs of many individuals with genetic diseases, as discussed in a session of the second annual American Society of Gene & Cell Therapy Policy Summit on September 24.  Discuss
Are people in your state getting vaccinated?
Support for a COVID-19 vaccine continues to wane even as companies report being closer to bringing one to the public. This may not be surprising, considering people in many U.S. states don't get inoculated for other diseases such as polio and the flu.  Discuss
SARS-CoV-2 transcriptional patterns provide new insights into infection
New web resources provide insights into cellular genes that are impacted by coronavirus infection in the context of host molecular signaling pathways. These insights have the potential to speed novel drug development efforts in the fight against COVID-19, according to a new paper published in Scientific Data on September 22.  Discuss
New in vitro models reveal importance of lung stem cells in SARS-CoV-2 infection
Researchers have developed a new 2D lung organoid in vitro model as a physiologically relevant platform to aid drug development and explore the pathogenesis of SARS-CoV-2 infection. Details were published online in Cell Stem Cell on September 18.  Discuss
Analysis of COVID-19 literature identifies possible knowledge gaps
An analysis of COVID-19 scientific abstracts using natural language processing and machine-learning techniques suggests that the literature currently lacks basic research on the pathogenesis and viral transmission of SARS-CoV-2, according to a September 16 article published in Patterns.  Discuss
Celebration of postdocs transitions to virtual platform
For the first time ever, the National Postdoctoral Association will celebrate National Postdoc Appreciation Week from September 21-25 as a virtual, collaborative event among multiple institutions. Executive Director Tom Kimbis discusses how the organization is adapting to meet the challenges of COVID-19 to support and advocate for postdocs.  Discuss
Could heparin-based therapies be a viable treatment for COVID-19?
Researchers have identified a novel approach to treating SARS-CoV-2 infection, spurred by a new understanding of viral attachment involving a heparan sulfate, a common glycoprotein. The results are presented in a September 14 article published in Cell.  Discuss
Antibody fragments may be exceptionally effective against SARS-CoV-2
An engineered antibody fragment has been developed as a highly potent neutralizer of SARS-CoV-2. For the first time, one of these tiny molecules has been tested for efficacy in in vitro and in vivo infection models. The results of the collaborative study were published in Cell on September 14.  Discuss
Optofluidics technology accelerates discovery of COVID-19 treatments
Known for its transformative technology, Berkeley Lights is a pioneer in optofluidics, which has supported the biopharmaceutical industry for years with its deep cell characterization capabilities. These efforts are highlighted by the rapid impact that Berkeley Lights' Beacon systems had during the early days of the COVID-19 pandemic.  Discuss
New approach to cancer immunotherapies combines 2 mAb treatments
A new approach to increasing the effectiveness of current cancer immunotherapies combines existing therapies with new monoclonal antibodies (mAb) that block inhibitory cytokines in tumor microenvironments, allowing the body to effectively eliminate tumors. The results of the study were published in Nature Communications on September 11.  Discuss
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