Immune system power may lessen reliance on antibiotics for tuberculosis
Francis Crick Institute researchers have found that the body’s natural process of removing old and damaged cell parts may be an essential part of tackling infections like tuberculosis (TB) that take hold within cells. They hypothesized that harnessing this process might present alternatives to antibiotics or improve antibiotic use. Their study was published in Nature Microbiology on Friday -- World TB Day. Read More
Shared genetic markers linked with substance use disorders
By combing through genomic data from more than one million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. Read More
RNA-seq analysis links protein to spread of pancreatic cancer, reveals potential drug target
An analysis of 400 pancreatic cancer tumor samples has linked a protein that controls RNA processing to the formation of metastases, suggesting that it may be possible to delay the spread of the cancer. Read More
A*STAR partners with startup to create diabetes cell therapies tailored to Asian patients
BetaLife has acquired the rights to human induced pluripotent stem cell (iPSC) technology from Singapore’s Agency for Science, Technology, and Research (A*STAR) for use in the treatment of diabetes. Read More
Neutrophil culprits cause pancreatic cancer treatment resistance
Researchers have discovered how immature neutrophils -- white blood cells that are an important part of the immune system -- are hijacked by pancreatic cancers to drive treatment resistance. The study, published Wednesday in Cancer Discovery, may facilitate new pancreatic cancer treatment avenues. Read More
Contagious fungal infections increase dramatically
According to national surveillance data, candidiasis cases caused by Candida auris, a highly infectious fungus, rose drastically between 2019 and 2021, reflecting increased transmission. Read More
Gestational diabetes rise linked to screening practices
A Canadian Medical Association Journal study published Monday found that although gestational diabetes is reportedly on the rise, changes in screening practices may largely explain the increase. Read More
Implication of nervous system in anaphylaxis opens ways to treat severe allergic reactions
Heat-sensing neurons are key contributors to severe allergic shock reactions, according to a study in mice that points to ways to reverse life-threatening symptoms. Read More
Clinical investigators need to be wary of confounding and bias in real-world studies; here is what to look for and how to address it
Clinical investigators use real-world data (RWD) in randomized trials and observational studies to produce real-world evidence (RWE) used to assess the safety and efficacy of an intervention and to inform product development, regulatory approval, and post-market surveillance efforts. Read More
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity. Read More
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