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New DNA editing tool could enable more personalized cell therapies
University of Minnesota, Twin Cities researchers have developed a new tool to predict and customize the rate of a type of DNA editing called site-specific recombination, offering the potential for more personalized cell therapies.
Current COVID-19 boosters provide protections against serious infection: study
Despite the evolution of the SARS-CoV-2 pandemic coronavirus, a new laboratory study conducted by a team of international researchers suggests current vaccine boosters may elicit sufficient immune protection against severe omicron-induced COVID-19 disease.
Loss of protective protein linked to age-related changes in the eye
A study in mice has shown that the loss of a protein that protects retinal support cells may drive aging-associated diseases of the retina such as macular degeneration.
Single-cell analyses shed light on drug resistance of melanoma brain metastases
Using single-cell genetic analyses of frozen brain samples, Columbia University researchers have uncovered evidence of how melanoma brain metastases evade current treatments.
RNA molecules identified as potential ‘common driver’ of cancer progression
Moffitt Cancer Center researchers have challenged the widely held view that protein structure and function are the key drivers of cancer development. Their study found competitive endogenous RNA drive melanoma growth and metastasis by blocking the antitumor activity of other molecules.
Cardiac mouse model shows role white blood cells play in arrhythmia
Feeding mice a diet lacking in potassium induces ventricular tachycardia, a rapid heartbeat, enabling researchers to study how different white blood cell subclasses influence heart rhythms.
CRISPR reveals interconnected map of immune feedback loops, regulatory networks
The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases.
Researchers capture images of antibody attacking neuron receptor
U.S. and German researchers have captured the first images of an antibody attacking a nerve cell surface receptor using cryo-electron microscopy, a technique that freezes proteins in place to get high-resolution microscopic images, according to a study published in
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal
Large DNA insertions in CRISPR-edited cells could increase cancer risk: study
CRISPR-Cas9 can cause large rearrangements of DNA through retrotransposition to theoretically trigger tumor development, according to a paper published in
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Researchers further understanding of microglia, immune cells that reside in the brain
Molecule inhibits drug-resistant bacteria in mice with pneumonia, UTIs
Georgetown gets $12.5M NSF award to create institute for emerging virus research
AI, computer models of brain cells open door to experiments not possible in lab
Researchers overcome NMR concentration limitation with powerful amplifier
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