Magnetic microdroplets reveal how cells sense mechanical signals during tissue development
Manipulation of magnetic microdroplets has revealed how stem cells in a living embryo mechanically test their environment to communicate with neighboring cells. Read More
MIT researchers record cellular memories through protein chains
Using engineered proteins, MIT researchers have designed a system in which they can record “memories” of sequences of cellular events, such as when certain genes are activated, or how cells respond to a drug, as cells turn on series of genes and pathways in performing functions. Read More
Boosting RNA therapies to create natural pacemakers
Smidt Heart Institute scientists have investigated how biological pacemaker cells fight back against RNA therapies to correct abnormal heartbeat rates. Read More
Discovery of toxin linked to severe COVID-19 points to new way to treat disease
A viral toxin produced by the SARS-CoV-2 virus may damage cell barriers, inducing vascular leak and driving severe COVID-19 infections, according to researchers at the University of California, Berkeley (UC Berkeley). Read More
AI provides evidence that gene length explains age-related molecular changes
Artificial intelligence (AI) has helped Northwestern University researchers find evidence that the length of genes explains most of the molecular-level changes that occur during aging, which they contend could lead to therapeutics that slow or even reverse the process. Read More
Functional genomics reveals gateway to intracellular targets for large molecules
Complementary genome-scale, chemical-genetic approaches have revealed a cellular gateway that could allow large molecules to enter cells, providing new opportunities to develop drugs for intracellular targets, according to University of California San Francisco (UCSF) researchers. Read More
Sound waves sort extracellular vesicles to enable liquid biopsies, regenerative therapies
Duke University engineers have used sound waves to separate small extracellular vesicles from biofluids, laying the groundwork for the development of next-generation liquid biopsies and regenerative therapies. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer. Read More
Penn researchers create adrenal gland organoid using stem cells
A research team, led by the University of Pennsylvania's School of Veterinary Medicine, has used stem cells to grow an organoid in a petri dish with the characteristics and functions of a human fetal adrenal gland. Read More
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