Genomics
Alternative gene therapies could be effective in treating some rare diseases
Bacteria-mediated genetic transfer has emerged as an alternative gene therapy (AGT) for the treatment of some rare diseases, such as phenylketonuria (PKU). This type of therapy is advantageous because it is easily regulated through established protein expression systems. One company, Synlogic, has developed an AGT candidate that uses a bacterial vector to treat PKU. Read More
Prime editing shows promise for complex diseases like cystic fibrosis
Researchers have demonstrated that prime editing -- a newer version of CRISPR-Cas9 gene editing -- can be successfully employed to correct gene mutations that cause cystic fibrosis. The new study, which tested the technique in human organoids, was published in Life Science Alliance on August 9. Read More
Voyager advances gene therapy platform for CNS diseases
Voyager Therapeutics has launched new gene therapy programs for Huntington's disease, amyotrophic lateral sclerosis caused by mutation in the SOD1 gene, spinal muscular atrophy, and diseases linked to glucosylceramidase beta mutations, powered by its proprietary adeno-associated virus capsids. Read More
Researchers identify chronic stress gene target in brain
By studying how genes affect receptors in the brain under stress, researchers have discovered new molecular mechanisms behind the function of corticosterone, the stress hormone. The research was published in Nature Communications on August 6. Read More
New sequencing workflow efficiently maps protein-protein interactions
A new tool called protein-protein interaction sequencing (PROPER-seq) allows researchers to map complex networks of proteins within cells of interest without the need for specialized resources, like antibodies or premade gene libraries. The methodology was published in Molecular Cell on August 3. Read More
PacBio reports growth in Q2, acquires Circulomics
Pacific Biosciences of California (PacBio) announced that its revenues soared a whopping 79% in the second quarter of 2021, and it has acquired the high-molecular-weight DNA extraction company Circulomics. Read More
Sunlight causes DNA damage associated with melanoma
Unlike other cancers, melanoma results from a chemical reaction that damages DNA and is fueled by sunlight, according to a new study published in Science Advances on July 30. Read More
Integral Molecular launches protein engineering platform
Integral Molecular announced the launch of its proprietary protein engineering platform, GeneCanvas, for the optimization of transgenes and other elements that are essential for gene therapy development. Read More
Machine learning identifies genes important for cancer growth
Using machine learning, researchers have developed a method that evaluates the contributions of all possible tumor mutations to the development and progression of cancer. The results of the study were published in Nature on July 28. Read More
BioTools Innovator selects 10 accelerator semifinalists
BioTools Innovator has selected 10 companies to participate in the organization's inaugural three-month virtual mentorship-focused accelerator program. Read More
Conferences
Bio-IT World Conference and Expo
September 20-22
Boston, Massachusetts United States
BioProcess International
September 20-23
Boston, Massachusetts United States
Cell and Gene Therapy Manufacturing and Commercialization
September 20-23
Boston, Massachusetts United States
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