Genomics Sponsored by Nvidia
New COVID-19 immunogen could help with early diagnosis
A new assay that detects the unique SARS-CoV-2 orf8 protein in the sera of COVID-19 patients in the early stage of the infection is a strategic step in controlling the COVID-19 pandemic, according to research published online October 20 in mBio.  Discuss
New method reclaims resolution of single-cell RNA-seq
A new approach to RNA sequencing can enable scientists to extract 10 times more information from a single cell, including gene expression and subtle differences between healthy and diseased cells. The study, published in Immunity on October 13, reveals the power of the improved Seq-Well method and provides evidence of its efficacy in five inflammatory skin diseases.  Discuss
Novel nanoparticles deliver genetic therapy to bone marrow
Specialized nanoparticles can be used to deliver small interfering RNA to the bone marrow where they can turn off specific genes in bone-marrow endothelial cells to help treat heart disease or boost stem cell production, according to new research published in Nature Biomedical Research on October 5.  Discuss
Neanderthal heritage may be a risk factor for COVID-19
A new study shows that a genetic risk factor inherited from Neanderthal heritage is associated with two times greater risk of serious disease and death from COVID-19. The study was published in Nature on September 30.  Discuss
Science serves society, a crucial concept for gene therapy governance
With a focus on science and society, the American Society of Gene & Cell Therapy Policy Summit commenced on September 24. The ensuing discussion revealed how far science has advanced in a short period of time, and how the scientific community is rising to the challenge of gaining public buy-in for gene therapy.  Discuss
SARS-CoV-2 transcriptional patterns provide new insights into infection
New web resources provide insights into cellular genes that are impacted by coronavirus infection in the context of host molecular signaling pathways. These insights have the potential to speed novel drug development efforts in the fight against COVID-19, according to a new paper published in Scientific Data on September 22.  Discuss
Making CRISPR safer with new enzyme-based prediction tool
A new technique will help scientists choose the best available gene editing option for any given indication, making CRISPR technology safer, cheaper, and more effective. The tool is outlined in a September 7 article in Nature Biotechnology.  Discuss
Protein engineering creates highly potent experimental SARS-CoV-2 vaccine
A bioengineering technique that utilizes various naturally occurring sequences and de novo design of messenger RNA (mRNA) components was applied to develop an mRNA-based vaccine that could be highly effective against SARS-CoV-2, according to a new article published in Advanced Materials on September 2.  Discuss
Detecting SARS-CoV-2 in blood may be early indicator of severe disease
A blood test that measures SARS-CoV-2 RNA when patients are admitted to the hospital with COVID-19 symptoms can be a powerful diagnostic tool to predict how severe their disease will be, according to a study published in Clinical Infectious Diseases on August 28. Patients without viral RNA in their blood have a good chance at rapid recovery, concluded researchers from Karolinska Institutet and Danderyd Hospital.  Discuss
Molecular barcoding of DNA identifies rare mutations in stem cells
Scientists have developed a new next-generation sequencing technique using molecular barcodes that can accurately detect a single genetic mutation in a pool of 10,000 cells. The researchers applied the approach to CRISPR-Cas9 genome editing to search for undesirable mutations caused by the platform. The research and methods were published in Genome Biology on August 24.  Discuss
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