Genomics
Cryo-EM microscopy tool gets an atomic resolution look at "upgraded" CRISPR system
Researchers from Columbia University capture de novo images that reveal unexpected presence transposition proteins that are essential for interactions of CRISPR-like cascade complex. The study was published in Nature on December 18.  Discuss
Researchers work out the early steps that drive malignancy
Researchers from Yale University have identified cellular characteristics that lead to the early stages of malignancy. They state that in at least one form of blood cancer, cells with cancer-causing lesions can remain normal until cell division speeds up the process. The results were published in Nature Communications on December 18.  Discuss
Algorithm provides new insight into hierarchical DNA structures that influence disease
Researchers develop an algorithm that locates specific topologically associating domains (TADs) which are implicated in disease development, including cancer. The technology, called OnTAD, can examine internal architectures of TADs, which are important in elucidating their biological functions. The work was published in Genome Biology on December 18.  Discuss
Researchers explore the role of circular DNA in deadly childhood cancer
Researchers from Charité - University Medicine Berlin and the Memorial Sloan Kettering Cancer Center in New York combine genomic and transcriptomic approaches to describe the landscape of extrachromosomal circular DNA in neuroblastoma. The work was published in Nature Genetics on December 16.  Discuss
New CRISPR system efficiently battles antibiotic resistance
Researchers from the University of California San Diego have developed a brand new CRISPR-based gene-drive system that dramatically increases the efficiency of inactivation of genes responsible for antibiotic resistance. The new system is detailed on December 16 in Nature Communications.  Discuss
Leveraging new technologies to push the boundaries of our knowledge of cell biology
At the American Society of Cell Biology, European Molecular Biology Organization Joint Meeting in Washington, DC from December 7-11, emerging topics and new technologies were discussed and highlighted. Proteomics and genomics seemed to be a focus of the meeting. Many researchers presented novel ideas to incorporate new technologies in these fields to make discoveries in cell biology.
In vitro CRISPR system allows scientists to detect broad outcomes
As CRISPR technology advances, it is crucial to identify all unintended and potentially harmful changes introduced by gene-editing processes. A new study published in Communications Biology introduces a new system that details broad spectrum outcomes of gene-editing reactions in an unbiased fashion.  Discuss
Scientists use antibodies to build nanostructures
Researchers from the University of Rome, Tor Vergata demonstrate a new model to control the construction of nanostructures using antibodies. The findings were published in Nature Communications on December 3.  Discuss
New method reveals 3D DNA structure
The scientist who developed a new method of illuminating 3D genomic structures, called Dip-C, is awarded the SciLifeLab Prize for Young Scientists by the Science for Life Laboratory in Sweden and the journal Science. The research of the grand prize winner, Longzhi Tan, builds on the work of the Human Genome Project by developing an algorithm to capture diploid chromosome conformation.  Discuss
Data Science Vital to Large-Scale Cellular Studies
Data science as a discipline has become a central aspect of many commercial endeavors. A large range of distinct applications have adopted its approaches and techniques. Despite the major differences in many of these applications, some of the techniques can be transferred from old and established data-driven fields to new, completely separate data-intensive areas. For example, certain image analysis algorithms from astronomy can be applied in fields involving microscopy.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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