Cell Biology
New method creates insights into T-cell responses to infections
Researchers have developed a method to study the specialization of T cells in the context of acute versus chronic infections. They found that T-cell responses can vary based on receptor signal strength and the persistence of infection in a study published in eLife on March 8. Read More
RNA editing affects gene expression -- with disease implications
Researchers found that RNA editing events can have large downstream effects that influence gene expression and subsequent phenotypic manifestations of that expression. RNA editing may be a previously underappreciated mechanism driving human diseases, according to an analysis published in Genome Biology on March 9. Read More
Researchers extract new layer of data with proteomic analysis of cancers
Researchers have demonstrated the utility of proteomics in the analysis of seven aggressive cancers among a cohort of nearly 800 patient samples. The analysis, published in Oncogene on February 24, reveals potentially novel therapeutic targets. Read More
Researchers discover potent inhibitors of SARS-CoV-2 main protease
Researchers have identified protein compounds that are potent inhibitors of the SARS-CoV-2 main protein, a key enzyme that enables the replication of the deadly virus. Their screening and synthetic chemistry approach was detailed in an article published March 3 in Angewandte Chemie. Read More
Combo of CRISPR, informatics helps uncover genetic regulators of immune cells
A new computational tool that uses CRISPR and multimodal single-cell sequencing data can provide insights into the function and regulation of human genes. The study, published in Nature Genetics on March 1, provides details on the molecular regulation of immune checkpoint inhibitors. Read More
Scientists achieve milestone in animal-free production of biologics
For the first time, scientists have successfully produced sugar-based biologic molecules utilizing bacteria, without the need for animal products. The paper, published in Nature Communications on March 2, describes the production of a common designer polysaccharide, chondroitin sulfate. Read More
Single-cell RNAseq differentiates cancer stem cells from healthy stem cells
Researchers have described a new single-cell RNA-sequencing approach, leveraging genomic and mitochondrial DNA mutations, that has the potential to differentiate normal stem cells from cancer stem cells. The article detailing the approach was published in Nature Communications on March 1. Read More
Game theory reveals how SARS-CoV-2 tricks human cells
Researchers have applied game theory in an effort to understand how SARS-CoV-2 mimics host proteins to support its own replication. The work, published in Royal Society Interface on February 24, applied a type of game theory on how information is signaled to reveal how the virus tries to trick human cells from attacking it. Read More
New technique detects unique folding patterns in RNA of SARS-CoV-2
Scientists have developed a new technique for determining alternative structural RNA shapes of the SARS-CoV-2 virus. These self-regulatory segments of RNA, called switches, could serve as potential antiviral drug targets, according to a communication published in Nature Methods on February 22. Read More
AI uncovers the genome's hidden regulatory code
A neural network trained on high-resolution maps of protein-DNA interactions can uncover how these sequences are organized to regulate genes, revealing a hidden regulatory code. Findings from use of the artificial intelligence (AI) model were published in Nature Genetics on February 18. Read More
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